High Cooperativity in Negative Feedback can Amplify Noisy Gene Expression

Burst-like synthesis of protein is a significant source of cell-to-cell variability in protein levels. Negative feedback is a common example of a regulatory mechanism by which such stochasticity can be controlled. Here we consider a specific kind of negative feedback, which makes bursts smaller in t...

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Bibliographic Details
Published in:	Bulletin of mathematical biology Vol. 80; no. 7; pp. 1871 - 1899
Main Authors:	Bokes, Pavol, Lin, Yen Ting, Singh, Abhyudai
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.07.2018 Springer Nature B.V
Subjects:	Algorithms Animals Bursting strength Cell Biology Coefficient of variation Computer Simulation Feedback Feedback, Physiological Gene Expression Humans Life Sciences Load Markov Chains Mathematical and Computational Biology Mathematical Concepts Mathematics Mathematics and Statistics Models, Genetic Negative feedback Original Article Protein biosynthesis Protein Biosynthesis - genetics Proteins Regulatory mechanisms (biology) Single-Cell Analysis Stochastic Processes Stochasticity Variation Asymptotic expansions Negative feedback 60K40 Stochastic gene expression Delayed production 41A60 Protein bursting 92C40
ISSN:	0092-8240, 1522-9602, 1522-9602
Online Access:	Get full text
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