Identification of transcriptomic sepsis endotypes in sub-Saharan Africa: derivation, validation, and global alignment in two Ugandan cohorts

Purpose Sub-Saharan Africa carries the highest global burden of critical illness, yet transcriptomic sepsis endotypes have not been defined in the region. Their clinical relevance and alignment with endotypes identified in high-income countries (HICs) remain unknown. Methods We analyzed data from tw...

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Bibliographic Details
Published in:	Intensive care medicine Vol. 51; no. 9; pp. 1573 - 1586
Main Authors:	Cummings, Matthew J., Lutwama, Julius J., Tomoiaga, Alin S., Zhao, Meng, Owor, Nicholas, Lu, Xuan, Eliku, Peter James, Ross, Jesse E., Nsereko, Christopher, Nayiga, Irene, Kyebambe, Stephen, Nsubuga, John Bosco, Shinyale, Joseph, Asasira, Ignatius, Kiyingi, Tonny, Ochar, Thomas, Kiwubeyi, Moses, Nankwanga, Rittah, Reynolds, Steven J., Nakibuuka, Martina Cathy, Kayiwa, John, Haumba, Mercy, Nakaseegu, Joweria, Che, Xiaoyu, Nie, Kai, Kim-Schulze, Seunghee, Ghosh, Sankar, Lipkin, W. Ian, O’Donnell, Max R., Bakamutumaho, Barnabas
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2025 Springer Nature B.V
Subjects:	Accuracy Adult Africa South of the Sahara Alignment Anesthesiology Bacterial infections Cell activation Classification Clustering Cohort Studies Critical Care Medicine Critical Illness Cytometry Emergency Medicine Enrollments Epidemiology Female Gene expression HIV Human immunodeficiency virus Humans Immune response Intensive Leukocytes (neutrophilic) Lymphocytes Malaria Male Medicine Medicine & Public Health Middle Aged Mortality Original Pain Medicine Pediatrics Physiology Pneumology/Respiratory System Prospective Studies Proteins Regression analysis Ribonucleic acid RNA Sepsis Sepsis - classification Sepsis - genetics Sepsis - mortality Transcriptome - genetics Transcriptomics Tuberculosis Uganda - epidemiology Africa South of the Sahara Uganda Africa Sepsis Precision medicine HIV High-throughput nucleotide sequencing Africa
ISSN:	0342-4642, 1432-1238, 1432-1238
Online Access:	Get full text
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