PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition

Vascular smooth muscle cells (SMCs) undergo phenotype switching to acquire various fates in response to pathological stimuli. Among these, 'synthetic' SMCs-defined by migration, proliferation and extracellular matrix production-accumulate in atherosclerotic lesions and contribute to fibrou...

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Bibliographic Details
Published in:	Nature cardiovascular research Vol. 4; no. 11; p. 1573
Main Authors:	Tan, Josephine M E, Cheng, Lan, Calhoun, Ryan P, Weller, Angela H, Drareni, Karima, Fong, Skylar, Barbara, Eirlys, Lim, Hee-Woong, Xue, Chenyi, Winter, Hanna, Auguste, Gaëlle, Miller, Clint L, Reilly, Muredach P, Maegdefessel, Lars, Lutgens, Esther, Seale, Patrick
Format:	Journal Article
Language:	English
Published:	England 01.11.2025
Subjects:	Animals Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Cell Movement Cell Proliferation Cells, Cultured Disease Models, Animal DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fibrosis Foam Cells - metabolism Foam Cells - pathology Gene Expression Regulation Humans Male Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Phenotype Plaque, Atherosclerotic Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism
ISSN:	2731-0590, 2731-0590
Online Access:	Get more information
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