Two scenarios for overcoming drug resistance by co-targeting

Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of the pathogen. After removing S, if the difference of sizes of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:International journal of bioinformatics research and applications Ročník 11; číslo 1; s. 72
Hlavní autoři: Taheri, Golnaz, Ayati, Marzieh, Wong, Limsoon, Eslahchi, Changiz
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland 2015
Témata:
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - metabolism
Computer Simulation
Drug Design
Drug Resistance, Bacterial - drug effects
Drug Resistance, Bacterial - physiology
Models, Biological
Protein Interaction Mapping - methods
Signal Transduction - drug effects
Signal Transduction - physiology
protein protein interaction
balanced bipartitioning
E coli
pathogens
C jejuni
bioinformatics
PPI networks
drug targets
essential pathways
drug resistance
co–targeting
ISSN:1744-5485
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of the pathogen. After removing S, if the difference of sizes of two partitions is high, the probability of existence of a functioning pathway is increased. We need to partition the graph into balanced partitions and approximate it with spectral bipartitioning. We consider two scenarios: in the first, we do not have any information on drug targets; in second, we consider information on drug targets. Our databases are E. coli and C. jejuni. In the first scenario, 20% and 17% of proteins in cut of E. coli and C. jejuni are drug targets and in the second scenario 53% and 63% of proteins in cut are drug targets respectively.
AbstractList Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of the pathogen. After removing S, if the difference of sizes of two partitions is high, the probability of existence of a functioning pathway is increased. We need to partition the graph into balanced partitions and approximate it with spectral bipartitioning. We consider two scenarios: in the first, we do not have any information on drug targets; in second, we consider information on drug targets. Our databases are E. coli and C. jejuni. In the first scenario, 20% and 17% of proteins in cut of E. coli and C. jejuni are drug targets and in the second scenario 53% and 63% of proteins in cut are drug targets respectively.
Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of the pathogen. After removing S, if the difference of sizes of two partitions is high, the probability of existence of a functioning pathway is increased. We need to partition the graph into balanced partitions and approximate it with spectral bipartitioning. We consider two scenarios: in the first, we do not have any information on drug targets; in second, we consider information on drug targets. Our databases are E. coli and C. jejuni. In the first scenario, 20% and 17% of proteins in cut of E. coli and C. jejuni are drug targets and in the second scenario 53% and 63% of proteins in cut are drug targets respectively.Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we consider a cut set S of simple graph G, where G representing the PPI network of the pathogen. After removing S, if the difference of sizes of two partitions is high, the probability of existence of a functioning pathway is increased. We need to partition the graph into balanced partitions and approximate it with spectral bipartitioning. We consider two scenarios: in the first, we do not have any information on drug targets; in second, we consider information on drug targets. Our databases are E. coli and C. jejuni. In the first scenario, 20% and 17% of proteins in cut of E. coli and C. jejuni are drug targets and in the second scenario 53% and 63% of proteins in cut are drug targets respectively.
Author Taheri, Golnaz
Ayati, Marzieh
Wong, Limsoon
Eslahchi, Changiz
Author_xml – sequence: 1
  givenname: Golnaz
  surname: Taheri
  fullname: Taheri, Golnaz
  organization: School of Mathematics and Computer Science and Center of Excellence in Bioinformatics, College of Science, University of Tehran, Tehran, Iran; Institute for Research in Fundamental Sciences (IPM), Tehran, Iran
– sequence: 2
  givenname: Marzieh
  surname: Ayati
  fullname: Ayati, Marzieh
  organization: Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA
– sequence: 3
  givenname: Limsoon
  surname: Wong
  fullname: Wong, Limsoon
  organization: Department of Computer Science, National University of Singapore, Singapore
– sequence: 4
  givenname: Changiz
  surname: Eslahchi
  fullname: Eslahchi, Changiz
  organization: Department of Computer Science, Shahid Beheshti University G.C., Tehran, Iran
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25667386$$D View this record in MEDLINE/PubMed
BookMark eNo1zztPwzAUBWAPRfQBP4AFeWRJ8OPaTiSWUhUoqoSEyhw5jh0FJXGxE1D_PZEo0x3Op6Nzl2jW-94idENJSgWB-93r4_s6ZYSKlEjFeTZDC6oAEgGZmKNljJ-EgGQgLtGcCTmZTC7Qw-HH42hsr0PjI3Y-YP9tg_Fd09e4CmONg41NHHRvLC5P2Phk0KG2w5RfoQun22ivz3eFPp62h81Lsn973m3W-8RwxYYkK4ELxxy3wHXFwGkpQTDDc3AAmuVaV9Y5rmhGSuMUnXSpuChVnjvQnK3Q3V_vMfiv0cah6Jppc9vq3voxFlQKkHnOSDbR2zMdy85WxTE0nQ6n4v9j9gtZtlg3
CitedBy_id crossref_primary_10_1016_j_asoc_2020_106202
crossref_primary_10_1016_j_inffus_2024_102485
crossref_primary_10_1016_j_asoc_2022_109510
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1504/IJBRA.2015.067338
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Biology
ExternalDocumentID 25667386
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
29J
4.4
53G
5GY
ABJNI
ACGFS
ACIWK
ACPRK
AFRAH
ALMA_UNASSIGNED_HOLDINGS
ALSBL
CGR
CS3
CUY
CVF
DU5
EBS
ECM
EIF
EJD
F5P
H13
HZ~
MET
MIE
NPM
O9-
P2P
RTD
7X8
ID FETCH-LOGICAL-c372t-8b435f2f3e43ad24fa66452c394f44a29aadeff37180bcf7135fb735b799f4a32
IEDL.DBID 7X8
ISSN 1744-5485
IngestDate Thu Jul 10 18:32:50 EDT 2025
Thu Jan 02 23:01:15 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords protein protein interaction
balanced bipartitioning
E coli
pathogens
C jejuni
bioinformatics
PPI networks
drug targets
essential pathways
drug resistance
co–targeting
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c372t-8b435f2f3e43ad24fa66452c394f44a29aadeff37180bcf7135fb735b799f4a32
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 25667386
PQID 1654699208
PQPubID 23479
ParticipantIDs proquest_miscellaneous_1654699208
pubmed_primary_25667386
PublicationCentury 2000
PublicationDate 2015-00-00
20150101
PublicationDateYYYYMMDD 2015-01-01
PublicationDate_xml – year: 2015
  text: 2015-00-00
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
PublicationTitle International journal of bioinformatics research and applications
PublicationTitleAlternate Int J Bioinform Res Appl
PublicationYear 2015
SSID ssj0046245
Score 1.9616972
Snippet Removal of proteins on an essential pathway of a pathogen is expected to prohibit the pathogen from performing a vital function. To disrupt these pathways, we...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 72
SubjectTerms Anti-Bacterial Agents - pharmacology
Bacterial Proteins - metabolism
Computer Simulation
Drug Design
Drug Resistance, Bacterial - drug effects
Drug Resistance, Bacterial - physiology
Models, Biological
Protein Interaction Mapping - methods
Signal Transduction - drug effects
Signal Transduction - physiology
Title Two scenarios for overcoming drug resistance by co-targeting
URI https://www.ncbi.nlm.nih.gov/pubmed/25667386
https://www.proquest.com/docview/1654699208
Volume 11
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7UKnjx_agvVvC6Nt1HswuCqFhUtBSp0FvY3eyKl6Q2rdJ_72yS6kkQvOQSQsLMZPebmW_nQ-gsYqZjfMSIp0oT3tacSMscxHLbea0p19Wc2ce415PDoerXBbeiplXO18RyoU5zG2rkrfLUjVI0kpejdxJUo0J3tZbQWEQNBlAmULri4XcXgXdoKVIMoJsTQOai7mqKiLfuH66frwKzS5wHqRYmf0eY5U7TXf_vN26gtRpj4qsqKDbRgsu20EqlOjnbRheDzxyHIU6QJucFBtSKA48TXgHbGE7H01cMOXjAlRAQ2MywzUlFGIf7O-ilezu4uSO1iAKxLKYTIg0AIk89c5zplHKvO6GXaZninoMnlNap8x58IyNjfVDs8yZmwsRKea4Z3UVLWZ65fYSpjiMvYmoFdzwNk_84ZHtSGOmpNiltotO5WRII0tB50JnLp0XyY5gm2qtsm4yqaRoJYK5SefTgD08fotXgsqoEcoQaHn5Rd4yW7cfkrRiflN6Ha6__9AW047ip
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Two+scenarios+for+overcoming+drug+resistance+by+co-targeting&rft.jtitle=International+journal+of+bioinformatics+research+and+applications&rft.au=Taheri%2C+Golnaz&rft.au=Ayati%2C+Marzieh&rft.au=Wong%2C+Limsoon&rft.au=Eslahchi%2C+Changiz&rft.date=2015-01-01&rft.issn=1744-5485&rft.volume=11&rft.issue=1&rft.spage=72&rft_id=info:doi/10.1504%2FIJBRA.2015.067338&rft_id=info%3Apmid%2F25667386&rft_id=info%3Apmid%2F25667386&rft.externalDocID=25667386
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1744-5485&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1744-5485&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1744-5485&client=summon