High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. Hig...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Tumor biology Ročník 37; číslo 3; s. 3581 - 3588
Hlavní autori: Yuan, Baoying, Wu, Changshun, Wang, Xingwen, Wang, Dan, Liu, Huiling, Guo, Ling, Li, Xiang-An, Han, Junqing, Feng, Hong
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Dordrecht Springer Netherlands 01.03.2016
Springer Nature B.V
Predmet:
Adult
Aged
Biomarkers, Tumor - biosynthesis
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer Research
Female
Follow-Up Studies
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphatic Metastasis
Medical prognosis
Middle Aged
Multivariate Analysis
Neoplasm Staging
Original Article
Prognosis
Proportional Hazards Models
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Scavenger Receptors, Class B - biosynthesis
Tissue Array Analysis - methods
Tissue Array Analysis - statistics & numerical data
Tumor Burden
Tumors
Immunohistochemistry
Scavenger receptor class B type I
Breast cancer
Prognosis
ISSN:1010-4283, 1423-0380
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage ( P  = 0.002), larger tumor size ( P  = 0.023), lymph node metastasis ( P  = 0.012), and the absence of ER ( P  = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) ( P  = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome ( P  = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.
Bibliografia:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-015-4141-4