Sex differences in left ventricular function and beta-receptor responsiveness following prolonged strenuous exercise
Sex differences in neuroendocrine and metabolic responses to prolonged strenuous exercise (PSE) have been well documented. The aim of this investigation was to examine sex differences in left ventricular function and cardiac beta-receptor responsiveness following a single bout of PSE. Nine male and...
Saved in:
| Published in: | Journal of applied physiology (1985) Vol. 102; no. 2; p. 681 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01.02.2007
|
| Subjects: | |
| ISSN: | 8750-7587 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Sex differences in neuroendocrine and metabolic responses to prolonged strenuous exercise (PSE) have been well documented. The aim of this investigation was to examine sex differences in left ventricular function and cardiac beta-receptor responsiveness following a single bout of PSE. Nine male and eight female triathletes were examined during three separate sessions: before, immediately after, and 24 h following a half-ironman triathlon using dobutamine stress echocardiography. Steady-state graded infusions of dobutamine were used to assess beta-receptor responsiveness. Slopes calculated from linear regressions between dobutamine doses and changes in heart rate and contractility for each participant were used as an index of beta-receptor responsiveness. Despite no change in preload, fractional area change decreased from baseline after the race in both men and women, with a greater decrease in men [men: 54.1% (SD 2.1) to 50.7% (SD 3.4) vs. women: 55.4% (SD 2.7) to 53.3% (SD 2.5); P < 0.05]. The amount of dobutamine necessary to increase heart rate by 25 beats/min [men: 29.6 microg x kg(-1) x min(-1) (SD 6.6) to 42.7 microg x kg(-1) x min(-1) (SD 12.9) vs. women: 23.5 microg x kg(-1) x min(-1) (SD 4.0) to 30.0 microg x kg(-1) x min(-1) (SD 7.8); P < 0.05] and contractility by 10 mmHg/cm2 [men: 20.9 microg x kg(-1) x min(-1) (SD 5.1) to 37.0 microg x kg(-1) x min(-1) (SD 11.5) vs. women: 22.6 microg x kg(-1) x min(-1) (SD 6.4) to 30.7 microg x kg(-1) x min(-1) (SD 7.2); P < 0.05] was greater in both men and women postrace. However, the amount of dobutamine required to induce these changes was greater in men, reflecting larger beta-receptor alterations in male triathletes following PSE relative to women. These data suggest that following an acute bout of PSE, male triathletes demonstrate an attenuated chronotropic and inotropic response to beta-adrenergic stimulation compared with female triathletes. |
|---|---|
| AbstractList | Sex differences in neuroendocrine and metabolic responses to prolonged strenuous exercise (PSE) have been well documented. The aim of this investigation was to examine sex differences in left ventricular function and cardiac beta-receptor responsiveness following a single bout of PSE. Nine male and eight female triathletes were examined during three separate sessions: before, immediately after, and 24 h following a half-ironman triathlon using dobutamine stress echocardiography. Steady-state graded infusions of dobutamine were used to assess beta-receptor responsiveness. Slopes calculated from linear regressions between dobutamine doses and changes in heart rate and contractility for each participant were used as an index of beta-receptor responsiveness. Despite no change in preload, fractional area change decreased from baseline after the race in both men and women, with a greater decrease in men [men: 54.1% (SD 2.1) to 50.7% (SD 3.4) vs. women: 55.4% (SD 2.7) to 53.3% (SD 2.5); P < 0.05]. The amount of dobutamine necessary to increase heart rate by 25 beats/min [men: 29.6 microg x kg(-1) x min(-1) (SD 6.6) to 42.7 microg x kg(-1) x min(-1) (SD 12.9) vs. women: 23.5 microg x kg(-1) x min(-1) (SD 4.0) to 30.0 microg x kg(-1) x min(-1) (SD 7.8); P < 0.05] and contractility by 10 mmHg/cm2 [men: 20.9 microg x kg(-1) x min(-1) (SD 5.1) to 37.0 microg x kg(-1) x min(-1) (SD 11.5) vs. women: 22.6 microg x kg(-1) x min(-1) (SD 6.4) to 30.7 microg x kg(-1) x min(-1) (SD 7.2); P < 0.05] was greater in both men and women postrace. However, the amount of dobutamine required to induce these changes was greater in men, reflecting larger beta-receptor alterations in male triathletes following PSE relative to women. These data suggest that following an acute bout of PSE, male triathletes demonstrate an attenuated chronotropic and inotropic response to beta-adrenergic stimulation compared with female triathletes.Sex differences in neuroendocrine and metabolic responses to prolonged strenuous exercise (PSE) have been well documented. The aim of this investigation was to examine sex differences in left ventricular function and cardiac beta-receptor responsiveness following a single bout of PSE. Nine male and eight female triathletes were examined during three separate sessions: before, immediately after, and 24 h following a half-ironman triathlon using dobutamine stress echocardiography. Steady-state graded infusions of dobutamine were used to assess beta-receptor responsiveness. Slopes calculated from linear regressions between dobutamine doses and changes in heart rate and contractility for each participant were used as an index of beta-receptor responsiveness. Despite no change in preload, fractional area change decreased from baseline after the race in both men and women, with a greater decrease in men [men: 54.1% (SD 2.1) to 50.7% (SD 3.4) vs. women: 55.4% (SD 2.7) to 53.3% (SD 2.5); P < 0.05]. The amount of dobutamine necessary to increase heart rate by 25 beats/min [men: 29.6 microg x kg(-1) x min(-1) (SD 6.6) to 42.7 microg x kg(-1) x min(-1) (SD 12.9) vs. women: 23.5 microg x kg(-1) x min(-1) (SD 4.0) to 30.0 microg x kg(-1) x min(-1) (SD 7.8); P < 0.05] and contractility by 10 mmHg/cm2 [men: 20.9 microg x kg(-1) x min(-1) (SD 5.1) to 37.0 microg x kg(-1) x min(-1) (SD 11.5) vs. women: 22.6 microg x kg(-1) x min(-1) (SD 6.4) to 30.7 microg x kg(-1) x min(-1) (SD 7.2); P < 0.05] was greater in both men and women postrace. However, the amount of dobutamine required to induce these changes was greater in men, reflecting larger beta-receptor alterations in male triathletes following PSE relative to women. These data suggest that following an acute bout of PSE, male triathletes demonstrate an attenuated chronotropic and inotropic response to beta-adrenergic stimulation compared with female triathletes. Sex differences in neuroendocrine and metabolic responses to prolonged strenuous exercise (PSE) have been well documented. The aim of this investigation was to examine sex differences in left ventricular function and cardiac beta-receptor responsiveness following a single bout of PSE. Nine male and eight female triathletes were examined during three separate sessions: before, immediately after, and 24 h following a half-ironman triathlon using dobutamine stress echocardiography. Steady-state graded infusions of dobutamine were used to assess beta-receptor responsiveness. Slopes calculated from linear regressions between dobutamine doses and changes in heart rate and contractility for each participant were used as an index of beta-receptor responsiveness. Despite no change in preload, fractional area change decreased from baseline after the race in both men and women, with a greater decrease in men [men: 54.1% (SD 2.1) to 50.7% (SD 3.4) vs. women: 55.4% (SD 2.7) to 53.3% (SD 2.5); P < 0.05]. The amount of dobutamine necessary to increase heart rate by 25 beats/min [men: 29.6 microg x kg(-1) x min(-1) (SD 6.6) to 42.7 microg x kg(-1) x min(-1) (SD 12.9) vs. women: 23.5 microg x kg(-1) x min(-1) (SD 4.0) to 30.0 microg x kg(-1) x min(-1) (SD 7.8); P < 0.05] and contractility by 10 mmHg/cm2 [men: 20.9 microg x kg(-1) x min(-1) (SD 5.1) to 37.0 microg x kg(-1) x min(-1) (SD 11.5) vs. women: 22.6 microg x kg(-1) x min(-1) (SD 6.4) to 30.7 microg x kg(-1) x min(-1) (SD 7.2); P < 0.05] was greater in both men and women postrace. However, the amount of dobutamine required to induce these changes was greater in men, reflecting larger beta-receptor alterations in male triathletes following PSE relative to women. These data suggest that following an acute bout of PSE, male triathletes demonstrate an attenuated chronotropic and inotropic response to beta-adrenergic stimulation compared with female triathletes. |
| Author | Haykowsky, Mark J Bredin, Shannon S D McKenzie, Don C Koehle, Michael S Isserow, Saul Esch, Ben T A Scott, Jessica M Hughes, Bevan G Zbogar, Dominik Warburton, Darren E R |
| Author_xml | – sequence: 1 givenname: Jessica M surname: Scott fullname: Scott, Jessica M organization: Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, British Columbia, Canada – sequence: 2 givenname: Ben T A surname: Esch fullname: Esch, Ben T A – sequence: 3 givenname: Mark J surname: Haykowsky fullname: Haykowsky, Mark J – sequence: 4 givenname: Saul surname: Isserow fullname: Isserow, Saul – sequence: 5 givenname: Michael S surname: Koehle fullname: Koehle, Michael S – sequence: 6 givenname: Bevan G surname: Hughes fullname: Hughes, Bevan G – sequence: 7 givenname: Dominik surname: Zbogar fullname: Zbogar, Dominik – sequence: 8 givenname: Shannon S D surname: Bredin fullname: Bredin, Shannon S D – sequence: 9 givenname: Don C surname: McKenzie fullname: McKenzie, Don C – sequence: 10 givenname: Darren E R surname: Warburton fullname: Warburton, Darren E R |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17082371$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kLtOwzAYRj0U0VJ4BfDEluJbamdEFTepEgMwV47zu7hy7WA70L49kSjTWY4-HX0XaBJiAIRuKFlQWrO7ne57338es4t-QchS0AUbMUEzJWtSyVrJKbrIeUcIFaKm52hKJVGMSzpD5Q0OuHPWQoJgIGMXsAdb8DeEkpwZvE7YDsEUFwPWocMtFF0lMNCXmHCC3MeQ3ahDzthG7-OPC1vcp-hj2EKHcxmnhzhkDAdIxmW4RGdW-wxXJ87Rx-PD--q5Wr8-vazu15XhkpWq5oIZroXlQvC2bSg1ltecdyClWipiGOtsQ1XbdLQWHdENNZwr1Sgr21YDm6Pbv90x5muAXDZ7lw14rwOMPZulahq6ZGIUr0_i0O6h2_TJ7XU6bv5_Yr9YJ3EN |
| CitedBy_id | crossref_primary_10_1007_s00421_018_3906_z crossref_primary_10_1113_jphysiol_2010_189886 crossref_primary_10_1007_s00421_011_2201_z crossref_primary_10_1016_j_amjcard_2010_02_037 crossref_primary_10_1080_17461390902763391 crossref_primary_10_1152_japplphysiol_01341_2009 crossref_primary_10_1249_MSS_0b013e318172cf10 crossref_primary_10_1139_apnm_2015_0491 crossref_primary_10_1152_japplphysiol_00595_2007c crossref_primary_10_1016_j_lfs_2021_120109 crossref_primary_10_1016_j_jacc_2021_08_003 crossref_primary_10_5402_2013_980824 crossref_primary_10_1152_physrev_00029_2014 crossref_primary_10_1249_MSS_0b013e318172cf36 crossref_primary_10_3390_jcm10173833 crossref_primary_10_1111_j_1540_8175_2010_01251_x crossref_primary_10_1152_japplphysiol_00898_2009 crossref_primary_10_1093_ejechocard_jen207 crossref_primary_10_3389_fphys_2025_1547894 crossref_primary_10_1136_hrt_2010_217133 crossref_primary_10_1152_japplphysiol_00570_2022 crossref_primary_10_1186_s44156_024_00066_9 crossref_primary_10_1016_j_echo_2017_04_008 crossref_primary_10_1186_2193_1801_1_46 crossref_primary_10_1186_2052_1847_6_24 crossref_primary_10_1186_s40798_024_00737_1 crossref_primary_10_1111_sms_12922 crossref_primary_10_1152_japplphysiol_00144_2008 crossref_primary_10_1152_japplphysiol_01242_2010 crossref_primary_10_1097_JSM_0000000000000130 crossref_primary_10_1007_s00421_009_1264_6 crossref_primary_10_1152_japplphysiol_00576_2013 crossref_primary_10_1249_MSS_0b013e31818313ff |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1152/japplphysiol.00641.2006 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| ExternalDocumentID | 17082371 |
| Genre | Comparative Study Clinical Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X .55 .GJ 18M 1CY 29J 2WC 39C 3O- 4.4 53G 5VS 85S 8M5 AAFWJ ABCQX ABDNZ ABHWK ABJNI ABKWE ABOCM ACBEA ACGFO ACGFS ACIWK ACKIV ACPRK ACYGS ADBBV ADFNX ADXHL AEILP AENEX AETEA AFOSN AFRAH AGCDD AGNAY AI. AIDAL AJUXI ALMA_UNASSIGNED_HOLDINGS BAWUL BKKCC BTFSW C1A C2- CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD EMOBN F5P FRP GX1 H13 H~9 ITBOX J5H KQ8 L7B MVM NEJ NPM OHT OK1 P-O P2P P6G PQQKQ RAP RHI RPL RPRKH SJN TR2 UHB UKR UPT VH1 W8F WH7 WOQ X7M XOL XSW YBH YQJ YQT YWH ZXP ~02 7X8 |
| ID | FETCH-LOGICAL-c372t-5342c3a4f3443bb911cf3533de778680c22df918b9d154d0a91c338898f7bbae2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 36 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000244033500026&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 8750-7587 |
| IngestDate | Fri Sep 05 13:00:37 EDT 2025 Fri Jun 06 19:40:31 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c372t-5342c3a4f3443bb911cf3533de778680c22df918b9d154d0a91c338898f7bbae2 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PMID | 17082371 |
| PQID | 68991624 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_68991624 pubmed_primary_17082371 |
| PublicationCentury | 2000 |
| PublicationDate | 2007-02-01 |
| PublicationDateYYYYMMDD | 2007-02-01 |
| PublicationDate_xml | – month: 02 year: 2007 text: 2007-02-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of applied physiology (1985) |
| PublicationTitleAlternate | J Appl Physiol (1985) |
| PublicationYear | 2007 |
| SSID | ssj0014451 |
| Score | 2.0287282 |
| Snippet | Sex differences in neuroendocrine and metabolic responses to prolonged strenuous exercise (PSE) have been well documented. The aim of this investigation was to... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 681 |
| SubjectTerms | Adrenergic beta-Agonists - pharmacology Adult Dobutamine - pharmacology Echocardiography, Stress Electrocardiography Exercise - physiology Female Heart - physiology Heart Rate - drug effects Heart Rate - physiology Humans Male Myocardial Contraction - drug effects Myocardial Contraction - physiology Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - physiology Sex Characteristics Time Factors Ventricular Function, Left - physiology |
| Title | Sex differences in left ventricular function and beta-receptor responsiveness following prolonged strenuous exercise |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/17082371 https://www.proquest.com/docview/68991624 |
| Volume | 102 |
| WOSCitedRecordID | wos000244033500026&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDLZ4CXHh_RjPHBC3iLbpllRCQggxcYBpEg_tNrVJOg2NdGwdj3-P3Yc4IQ5ceqvkxq792f5iA5xGRklp_Ban4WhUuvF4gricq1ZolRRaBMWw5-c72emoXi_qzsFFfReGaJW1Tywctck01cjPW4qQTBBejt847Yyi3mq1QGMeFgUCGSJ0yd5PD4FGb5XVPY8jKpYVuwsD1vkLdYeL0kE2ImZXWGSKrd9RZhFt2mv_k3MdViuUya5Ks9iAOes2YevKYYb9-sXOWLcUKht8bcLyfdVe34L8wX6yemUKOhA2dGxk05wRKbKoFMYTRpGQtMliZ1hi85ij07RjzN3ZpCLclg6UpWhj2QfGRobfMMrcwBpGd1PcLJtNWb3saRue2jeP17e8WsvAtZBBzpsiDLSIw1SEoUgS9JY6FYgajaVZdMrTQWDSyFdJZBCfGS-OfI2JsIpUKpMktsEOLLjM2T1gKqHGZKSN9lTYTL0okFJq5Rk0khgV14CT-pD7aPbUy4idRRn79TE3YLfUU39cTufo-7IYwOPv__nuAayUlVoipxzCYoo_vD2CJf2eD6eT48Ka8Nnp3n8DFibW2Q |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sex+differences+in+left+ventricular+function+and+beta-receptor+responsiveness+following+prolonged+strenuous+exercise&rft.jtitle=Journal+of+applied+physiology+%281985%29&rft.au=Scott%2C+Jessica+M&rft.au=Esch%2C+Ben+T+A&rft.au=Haykowsky%2C+Mark+J&rft.au=Isserow%2C+Saul&rft.date=2007-02-01&rft.issn=8750-7587&rft.volume=102&rft.issue=2&rft.spage=681&rft_id=info:doi/10.1152%2Fjapplphysiol.00641.2006&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=8750-7587&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=8750-7587&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=8750-7587&client=summon |