Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways

Exosomes are emerging as important elements that participate in intercellular communication and tumor microenvironment modulation, but the exact mechanisms by which tumor exosomes facilitate the generation of the immunosuppressive microenvironment remain unclear. Here we investigated the effects of...

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Bibliographic Details
Published in:	Oncogene Vol. 39; no. 2; pp. 428 - 442
Main Authors:	Qian, Mingyu, Wang, Shaobo, Guo, Xiaofan, Wang, Jian, Zhang, Zongpu, Qiu, Wei, Gao, Xiao, Chen, Zihang, Xu, Jianye, Zhao, Rongrong, Xue, Hao, Li, Gang
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2020
Subjects:	Cell Line, Tumor Cell signaling Exosomes Exosomes - metabolism Glioma Glioma - pathology Humans Hypoxia Immunotherapy Intracellular signalling Investigations Leukocyte migration Macrophages Macrophages - cytology Macrophages - immunology MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA NF-kappa B - metabolism NF-κB protein Phagocytosis - genetics Polarization Sequence analysis Shelterin Complex Signal Transduction Stat3 protein STAT3 Transcription Factor - metabolism Telomere-Binding Proteins - genetics Tumor Hypoxia
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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