Trauma-focused therapy in early psychosis: results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings

Trauma is prevalent amongst early psychosis patients and associated with adverse outcomes. Past trials of trauma-focused therapy have focused on chronic patients with psychosis/schizophrenia and comorbid Post-Traumatic Stress Disorder (PTSD). We aimed to determine the feasibility of a large-scale ra...

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Veröffentlicht in:Psychological medicine Jg. 54; H. 5; S. 874 - 885
Hauptverfasser: Varese, Filippo, Sellwood, William, Pulford, Daniel, Awenat, Yvonne, Bird, Leanne, Bhutani, Gita, Carter, Lesley-Anne, Davies, Linda, Aseem, Saadia, Davis, Claire, Hefferman-Clarke, Rebecca, Hilton, Claire, Horne, Georgia, Keane, David, Logie, Robin, Malkin, Debra, Potter, Fiona, van den Berg, David, Zia, Shameem, Bentall, Richard P.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Cambridge University Press 01.04.2024
Schlagworte:
Antipsychotics
Anxiety
Clinical outcomes
Clinical trials
Comorbidity
COVID-19
Desensitization
Early intervention
Efficacy
Evaluation
Eye movement desensitization
Eye Movement Desensitization Reprocessing - methods
Eye movements
Feasibility
Feasibility Studies
Fidelity
Health status
Humans
Intervention
Medical treatment
Mental depression
Mental disorders
Mental health
Multicenter studies
Pandemics
Patients
Post traumatic stress disorder
Psychosis
Psychotherapy
Psychotic Disorders - therapy
Psychotic symptoms
Psychotropic drugs
Recruitment
Schizophrenia
Schizophrenia - therapy
Stress Disorders, Post-Traumatic - diagnosis
Stress Disorders, Post-Traumatic - therapy
Subjectivity
Supervision
Symptoms
Therapy
Trauma
Treatment compliance
Treatment Outcome
Treatment outcomes
Video teleconferencing
United Kingdom > UK
eye movement desensitization and reprocessing
Trauma
psychosis
psychological therapies
randomized controlled trial
ISSN:0033-2917, 1469-8978, 1469-8978
Online-Zugang:Volltext
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Zusammenfassung:Trauma is prevalent amongst early psychosis patients and associated with adverse outcomes. Past trials of trauma-focused therapy have focused on chronic patients with psychosis/schizophrenia and comorbid Post-Traumatic Stress Disorder (PTSD). We aimed to determine the feasibility of a large-scale randomized controlled trial (RCT) of an Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) intervention for early psychosis service users. A single-blind RCT comparing 16 sessions of EMDRp + TAU TAU only was conducted. Participants completed baseline, 6-month and 12-month post-randomization assessments. EMDRp and trial assessments were delivered both in-person and remotely due to COVID-19 restrictions. Feasibility outcomes were recruitment and retention, therapy attendance/engagement, adherence to EMDRp treatment protocol, and the 'promise of efficacy' of EMDRp on relevant clinical outcomes. Sixty participants (100% of the recruitment target) received TAU or EMDR + TAU. 83% completed at least one follow-up assessment, with 74% at 6-month and 70% at 12-month. 74% of EMDRp + TAU participants received at least eight therapy sessions and 97% rated therapy sessions demonstrated good treatment fidelity. At 6-month, there were signals of promise of efficacy of EMDRp + TAU TAU for total psychotic symptoms (PANSS), subjective recovery from psychosis, PTSD symptoms, depression, anxiety, and general health status. Signals of efficacy at 12-month were less pronounced but remained robust for PTSD symptoms and general health status. The trial feasibility criteria were fully met, and EMDRp was associated with promising signals of efficacy on a range of valuable clinical outcomes. A larger-scale, multi-center trial of EMDRp is feasible and warranted.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Undefined-1
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ISSN:0033-2917
1469-8978
1469-8978
DOI:10.1017/S0033291723002532