Current Trends in Donor Testing to Detect Syphilis Infection

Potential organ and tissue donors are tested to detect infection with T. pallidum , the etiologic agent of syphilis. Important considerations for testing potential donors include available specimen type and volume, turnaround time, and ability to distinguish between past and current infection. Aspec...

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Bibliographic Details
Published in:Current infectious disease reports Vol. 16; no. 9; p. 423
Main Authors: Cortez, Karoll J., Greenwald, Melissa A.
Format: Journal Article
Language:English
Published: Boston Springer US 01.09.2014
Springer Nature B.V
Subjects:
Blood & organ donations
Diagnostic tests
Infectious Diseases
Medicine
Medicine & Public Health
Section Editor
Sexually transmitted diseases
STD
Syphilis
Topical Collection on Transplant and Oncology
Transplant and Oncology (M Ison
Reverse sequence algorithm
Donor testing
Treponemal
Syphilis
Organ donor
Traditional algorithm
Nontreponemal
Tissue donor
ISSN:1523-3847, 1534-3146
Online Access:Get full text
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Summary:Potential organ and tissue donors are tested to detect infection with T. pallidum , the etiologic agent of syphilis. Important considerations for testing potential donors include available specimen type and volume, turnaround time, and ability to distinguish between past and current infection. Aspects of syphilis infection that inform organ and tissue donor assay selection and interpretation and the principles underlying available assays are described. Serologic assays for syphilis are the methods most commonly used in donor testing. The two categories of serologic assays, treponemal and nontreponemal, have advantages and limitations for testing potential donors. Knowledge of the common syphilis-testing algorithms used in clinical diagnostic testing is useful for assay selection in the organ and tissue donor setting.
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ISSN:1523-3847
1534-3146
DOI:10.1007/s11908-014-0423-z