Site‐Specific Gingival Bleeding on Probing in a Steady‐State Plaque Environment: Influence of Polymorphisms in the Interleukin‐1 Gene Cluster

Background: We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)‐1A−889 and IL‐1B+3954 in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present s...

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Veröffentlicht in:	Journal of periodontology (1970) Jg. 81; H. 1; S. 52 - 61
Hauptverfasser:	Müller, Hans‐Peter, Barrieshi‐Nusair, Kefah M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chicago, IL American Academy of Periodontology 01.01.2010
Schlagworte:	Adult Arabs - genetics Biological and medical sciences Dental plaque Dental Plaque - physiopathology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Genetic Predisposition to Disease Gingival Hemorrhage - etiology Gingival Hemorrhage - genetics gingivitis Gingivitis - complications Gingivitis - genetics Humans Interleukin-1alpha - genetics Interleukin-1beta - genetics interleukin‐1 Male Medical sciences Multilevel Analysis multivariate analysis Non tumoral diseases Otorhinolaryngology. Stomatology Periodontal Index Polymorphism, Genetic Reference Values Young Adult genetic interleukin-1 Stomatology Dental disease Dental plaque Dentistry Multivariate analysis Gingivitis Hemorrhage Steady state Periodontal disease Gene Interleukin 1 Environment Genetics Gingiva Polymorphism
ISSN:	0022-3492, 1943-3670, 1943-3670
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Abstract	Background: We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)‐1A−889 and IL‐1B+3954 in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level. Methods: Fifty healthy non‐smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL‐1 gene cluster were assessed using a reverse hybridization assay. Results: Twenty‐six subjects (52%) carried alleles 2 at positions IL‐1A−889 and IL‐1B+3954 and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL‐1 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; χ2(3) = 11.946; P = 0.008) or 1 (χ2(3) = 6.027; P = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL‐1 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level. Conclusion: Multilevel modeling of site‐specific data yielded new information about the influence of the IL‐1 genotype in plaque‐induced gingivitis.
AbstractList	We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)-1A(-889) and IL-1B(+3954) in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level. Fifty healthy non-smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL-1 gene cluster were assessed using a reverse hybridization assay. Twenty-six subjects (52%) carried alleles 2 at positions IL-1A(-889) and IL-1B(+3954) and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL-1 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; chi(2)((3)) = 11.946; P = 0.008) or 1 (chi(2)((3)) = 6.027; P = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL-1 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level. Multilevel modeling of site-specific data yielded new information about the influence of the IL-1 genotype in plaque-induced gingivitis. Background: We previously reported a high prevalence of a combination of alleles 2 at positions interleukin ( IL)‐1A −889 and IL‐1B +3954 in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level. Methods: Fifty healthy non‐smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL‐1 gene cluster were assessed using a reverse hybridization assay. Results: Twenty‐six subjects (52%) carried alleles 2 at positions IL‐1A −889 and IL‐1B +3954 and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL‐1 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; χ 2 (3) = 11.946; P = 0.008) or 1 (χ 2 (3) = 6.027; P = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL‐1 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level. Conclusion: Multilevel modeling of site‐specific data yielded new information about the influence of the IL‐1 genotype in plaque‐induced gingivitis. Background: We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)‐1A−889 and IL‐1B+3954 in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level. Methods: Fifty healthy non‐smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL‐1 gene cluster were assessed using a reverse hybridization assay. Results: Twenty‐six subjects (52%) carried alleles 2 at positions IL‐1A−889 and IL‐1B+3954 and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL‐1 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; χ2(3) = 11.946; P = 0.008) or 1 (χ2(3) = 6.027; P = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL‐1 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level. Conclusion: Multilevel modeling of site‐specific data yielded new information about the influence of the IL‐1 genotype in plaque‐induced gingivitis. We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)-1A(-889) and IL-1B(+3954) in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level.BACKGROUNDWe previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)-1A(-889) and IL-1B(+3954) in an Arabic population with gingivitis. In a steady state, the proportion of sites with bleeding on probing (BOP) was consistently reduced. The aim of the present study is to expand this observation by considering the site level.Fifty healthy non-smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL-1 gene cluster were assessed using a reverse hybridization assay.METHODSFifty healthy non-smoking volunteers, 19 to 28 years of age, participated in this study. Clinical examinations included probing depth, BOP, plaque index (PI), and calculus. Examinations were repeated after 2 and 4 weeks, and subjects were advised not to change oral hygiene habits. Polymorphisms in the IL-1 gene cluster were assessed using a reverse hybridization assay.Twenty-six subjects (52%) carried alleles 2 at positions IL-1A(-889) and IL-1B(+3954) and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL-1 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; chi(2)((3)) = 11.946; P = 0.008) or 1 (chi(2)((3)) = 6.027; P = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL-1 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level.RESULTSTwenty-six subjects (52%) carried alleles 2 at positions IL-1A(-889) and IL-1B(+3954) and were designated genotype positive. In multivariate multilevel models of BOP, bleeding tendency in subjects with positive IL-1 genotype was only reduced at sites with PI 0 (odds ratio of 0.98, 0.65, and 0.56 at baseline and 2 and 4 weeks, respectively; chi(2)((3)) = 11.946; P = 0.008) or 1 (chi(2)((3)) = 6.027; P = 0.110). A decreased bleeding tendency at certain tooth types in subjects who were IL-1 positive was largely related to the relative cleanliness of these areas. Random parts of the models revealed very low biserial correlations of 0.13 to 0.15 at the site level, whereas correlations were considerably higher (0.76 to 0.83) at the subject level.Multilevel modeling of site-specific data yielded new information about the influence of the IL-1 genotype in plaque-induced gingivitis.CONCLUSIONMultilevel modeling of site-specific data yielded new information about the influence of the IL-1 genotype in plaque-induced gingivitis.
Author	Müller, Hans‐Peter Barrieshi‐Nusair, Kefah M.
Author_xml	– sequence: 1 givenname: Hans‐Peter surname: Müller fullname: Müller, Hans‐Peter email: hans‐peter.muller@fagmed.uit.no – sequence: 2 givenname: Kefah M. surname: Barrieshi‐Nusair fullname: Barrieshi‐Nusair, Kefah M.
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Cites_doi	10.1007/s00784-008-0237-1 10.1111/j.1600-051X.2005.00810.x 10.5144/0256-4947.1999.206 10.1902/jop.2000.71.2.164 10.3109/00016356408993968 10.1111/j.1600-051X.1992.tb00673.x 10.1111/j.2044-8317.1997.tb01099.x 10.1902/jop.1965.36.3.177 10.1111/1467-985X.00156 10.1902/jop.1999.70.6.567 10.1034/j.1600-0765.2000.035002102.x 10.1111/j.1600-051X.2007.01145.x 10.1007/s007840100126 10.1111/j.1600-051X.1997.tb01187.x 10.1007/s00784-007-0120-5 10.1902/jop.2004.75.1.16 10.1902/jop.2005.76.1.49 10.1177/154405910308200308 10.1038/sj.gene.6363882 10.1902/jop.2003.74.12.1796 10.1902/jop.2000.71.2.156 10.1902/jop.1999.70.1.49 10.1016/S0198-8859(02)00440-8 10.1111/j.1600-051x.2004.00477.x 10.1007/s00784-006-0067-y 10.1007/s007840000078 10.1177/00220345000790110801 10.1902/jop.2005.76.2.234 10.1111/j.1600-051X.1986.tb00881.x 10.1034/j.1600-051X.2003.00218.x 10.1111/j.1600-051X.2004.00479.x 10.1111/j.1600-0765.1999.tb02265.x 10.1007/s00784-005-0001-8 10.1111/j.1600-051X.1975.tb01722.x 10.1111/j.1600-051x.2004.00478.x 10.1111/j.1600-0765.2006.00951.x 10.1034/j.1600-051x.2000.027011810.x 10.1034/j.1600-051x.2001.028005389.x 10.1111/j.1600-051X.2006.00993.x 10.1111/j.1600-051X.1995.tb00818.x 10.2307/2983328 10.1002/sim.1264 10.1111/j.1600-051X.1978.tb01903.x 10.1016/j.ygeno.2008.07.004 10.1093/ajcn/83.2.475S
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Keywords	genetic interleukin-1 Stomatology Dental disease Dental plaque Dentistry Multivariate analysis Gingivitis Hemorrhage Steady state Periodontal disease Gene Interleukin 1 Environment Genetics Gingiva Polymorphism
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References	2000; 27 1965; 36 2000; 4 2006; 10 2006; 33 1986; 13 1997; 24 1964; 22 1999; 45 1978; 5 1992; 19 2002; 3 2000; 71 2001; 28 2008; 92 2007; 11 2003; 30 2003; 74 2007; 34 2004; 31 2009; 13 2004; 75 1997; 50 2006; 83 2002; 63 2001; 5 1999; 19 2000; 35 2000; 79 2005; 9 1995; 22 2002; 21 1999; 34 1975; 2 2005; 32 2005; 76 2000; 163 1996; 159 2003; 82 2007; 42 1999; 70 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 Becker M (e_1_2_7_24_1) 1999; 45 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_37_1 e_1_2_7_38_1 e_1_2_7_39_1
References_xml	– volume: 32 start-page: 72 issue: Suppl. 6 year: 2005 end-page: 86 article-title: Effect of genetic variability on the inflammatory response to periodontal infection publication-title: J Clin Periodontol – volume: 82 start-page: 189 year: 2003 end-page: 193 article-title: The interleukin‐1 polymorphism, smoking, and the risk of periodontal disease in the population‐based SHIP study publication-title: J Dent Res – volume: 79 start-page: 1864 year: 2000 end-page: 1869 article-title: Polymorphisms in the IL‐1A gene are correlated with levels of interleukin‐1α protein in gingival crevicular fluid of teeth with severe periodontal disease publication-title: J Dent Res – volume: 13 start-page: 273 year: 2009 end-page: 278 article-title: Dealing with hierarchical data in periodontal research publication-title: Clin Oral Investig – volume: 5 start-page: 24 year: 1978 end-page: 34 article-title: Development of gingivitis in pre‐school children and young adults. A comparative experimental study publication-title: J Clin Periodontol – volume: 28 start-page: 389 year: 2001 end-page: 396 article-title: Interleukin‐1 gene polymorphism and periodontal status. A case‐control study publication-title: J Clin Periodontol – volume: 63 start-page: 1055 year: 2002 end-page: 1061 article-title: Frequency of cytokine polymorphisms in populations from Western Europe, Africa, the Middle East and South America publication-title: Hum Immunol – volume: 9 start-page: 278 year: 2005 end-page: 283 article-title: Gingival bleeding on repeat probing after different time intervals in plaque‐induced gingivitis publication-title: Clin Oral Investig – volume: 71 start-page: 156 year: 2000 end-page: 163 article-title: Interleukin‐1 genetic association with periodontitis in clinical practice publication-title: J Periodontol – volume: 22 start-page: 642 year: 1995 end-page: 647 article-title: Oral microbiota in subjects with a weak or strong response in experimental gingivitis publication-title: J Clin Periodontol – volume: 22 start-page: 121 year: 1964 end-page: 135 article-title: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition publication-title: Acta Odontol Scand – volume: 31 start-page: 253 year: 2004 end-page: 259 article-title: Modulation of clinical expression of plaque‐induced gingivitis. III. Response of “high responders” and “low responders” to therapy publication-title: J Clin Periodontol – volume: 24 start-page: 72 year: 1997 end-page: 77 article-title: The interleukin‐1 genotype as a severity factor in adult periodontal disease publication-title: J Clin Periodontol – volume: 11 start-page: 297 year: 2007 end-page: 302 article-title: A combination of alleles 2 of interleukin ( ) and is associated with lower gingival bleeding tendency in plaque‐induced gingivitis in young adults of Arabic heritage publication-title: Clin Oral Investig – volume: 30 start-page: 102 year: 2003 end-page: 106 article-title: Interleukin‐1 gene polymorphisms and experimental gingivitis publication-title: J Clin Periodontol – volume: 10 start-page: 311 year: 2006 end-page: 316 article-title: Multivariate multilevel models for repeated measures in the study of smoking effects on the association between plaque and gingival bleeding publication-title: Clin Oral Investig – volume: 21 start-page: 3291 year: 2002 end-page: 3315 article-title: Multilevel modeling of medical data publication-title: Stat Med – volume: 83 start-page: 475S issue: Suppl. year: 2006 end-page: 483S article-title: Interleukin 1 genetics, inflammatory mechanisms, and nutrigenic opportunities to modulate diseases of aging publication-title: Am J Clin Nutr – volume: 76 start-page: 234 year: 2005 end-page: 243 article-title: Association of interleukin‐1 polymorphisms with periodontal disease publication-title: J Periodontol – volume: 34 start-page: 1031 year: 2007 end-page: 1038 article-title: Role of IL‐6, TNF‐A and LT‐A variants in the modulation of the clinical expression of plaque‐induced gingivitis publication-title: J Clin Periodontol – volume: 4 start-page: 212 year: 2000 end-page: 218 article-title: Site‐specific association between supragingival plaque and bleeding upon probing in young adults publication-title: Clin Oral Investig – volume: 31 start-page: 229 year: 2004 end-page: 238 article-title: Modulation of clinical expression of plaque‐induced gingivitis. I. Background review and rationale publication-title: J Clin Periodontol – volume: 163 start-page: 49 year: 2000 end-page: 62 article-title: Multilevel models for repeated binary outcomes: Attitudes and voting over the electoral cycle publication-title: J Royal Stat Soc A – volume: 159 start-page: 505 year: 1996 end-page: 513 article-title: Improved approximations for multilevel models with binary responses publication-title: J Royal Stat Soc A – volume: 27 start-page: 810 year: 2000 end-page: 818 article-title: Microbiological parameters associated with IL‐1 gene polymorphisms in periodontitis patients publication-title: J Clin Periodontol – volume: 36 start-page: 177 year: 1965 end-page: 187 article-title: Experimental gingivitis in man publication-title: J Periodontol – volume: 31 start-page: 239 year: 2004 end-page: 252 article-title: Modulation of clinical expression of plaque‐induced gingivitis. II. Identification of “high‐responder” and “low‐responder” subjects publication-title: J Clin Periodontol – volume: 2 start-page: 14 year: 1975 end-page: 24 article-title: Experimental gingivitis in young and elderly individuals publication-title: J Clin Periodontol – volume: 19 start-page: 423 year: 1992 end-page: 433 article-title: Patterns of de novo plaque formation in the human dentition publication-title: J Clin Periodontol – volume: 42 start-page: 318 year: 2007 end-page: 324 article-title: Comparison of experimental gingivitis with persistent gingivitis: Differences in clinical parameters and cytokine concentrations publication-title: J Periodontal Res – volume: 70 start-page: 567 year: 1999 end-page: 573 article-title: The influence of interleukin gene polymorphism on expression of interleukin‐1β and tumor necrosis factor‐α in periodontal tissue and gingival crevicular fluid publication-title: J Periodontol – volume: 92 start-page: 309 year: 2008 end-page: 315 article-title: Polymorphisms in the interleukin‐1 ( ) gene cluster are not associated with aggressive periodontitis in a large Caucasian population publication-title: Genomics – volume: 19 start-page: 206 year: 1999 end-page: 210 article-title: Prevalence and social correlates to consanguinity in Kuwait publication-title: Ann Saudi Med – volume: 5 start-page: 177 year: 2001 end-page: 184 article-title: Bleeding on probing in smokers and non‐smokers in a steady‐state plaque environment publication-title: Clin Oral Investig – volume: 50 start-page: 21 year: 1997 end-page: 29 article-title: Extra‐binomial variation in multilevel logistic models with sparse structures publication-title: Br J Math Stat Psychol – volume: 34 start-page: 353 year: 1999 end-page: 357 article-title: Interleukin‐1 genotypes and the association between periodontitis and cardiovascular disease publication-title: J Periodontal Res – volume: 70 start-page: 49 year: 1999 end-page: 56 article-title: Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL‐1 genotype in accurately predicting prognoses and tooth survival publication-title: J Periodontol – volume: 71 start-page: 164 year: 2000 end-page: 171 article-title: Low prevalence of a periodontitis‐associated interleukin‐1 composite genotype in individuals of Chinese heritage publication-title: J Periodontol – volume: 3 start-page: 302 year: 2002 end-page: 305 article-title: IL‐1B and IL‐6 gene polymorphisms encode significant risk for the development of recurrent aphthous stomatitis (RAS) publication-title: Genes Immun – volume: 74 start-page: 1796 year: 2003 end-page: 1802 article-title: Distribution of interleukin‐1β and IL‐1α genetic variations in a Thai population group publication-title: J Periodontol – volume: 33 start-page: 811 year: 2006 end-page: 818 article-title: Effect of triclosan/copolymer‐containing toothpaste on the association between plaque and gingival bleeding: A randomized controlled clinical trial publication-title: J Clin Periodontol – volume: 35 start-page: 102 year: 2000 end-page: 107 article-title: Effect of interleukin‐1 gene polymorphisms on gingival inflammation assessed by bleeding on probing in a periodontal maintenance population publication-title: J Periodontal Res – volume: 75 start-page: 16 year: 2004 end-page: 22 article-title: The effect of cigarette smoking on gingival bleeding publication-title: J Periodontol – volume: 45 start-page: 499 year: 1999 end-page: 505 article-title: Reverse hybridization assay for rapid identification of periodontitis‐associated interleukin‐1 alleles publication-title: Clin Lab – volume: 76 start-page: 49 year: 2005 end-page: 56 article-title: Modulation of clinical expression of plaque‐induced gingivitis: Interleukin‐1 gene cluster polymorphisms publication-title: J Periodontol – volume: 13 start-page: 774 year: 1986 end-page: 782 article-title: Bleeding/plaque ratio and the development of gingival inflammation publication-title: J Clin Periodontol – ident: e_1_2_7_20_1 doi: 10.1007/s00784-008-0237-1 – ident: e_1_2_7_8_1 doi: 10.1111/j.1600-051X.2005.00810.x – ident: e_1_2_7_31_1 doi: 10.5144/0256-4947.1999.206 – ident: e_1_2_7_28_1 doi: 10.1902/jop.2000.71.2.164 – ident: e_1_2_7_23_1 doi: 10.3109/00016356408993968 – ident: e_1_2_7_3_1 doi: 10.1111/j.1600-051X.1992.tb00673.x – ident: e_1_2_7_47_1 doi: 10.1111/j.2044-8317.1997.tb01099.x – ident: e_1_2_7_37_1 doi: 10.1902/jop.1965.36.3.177 – ident: e_1_2_7_25_1 doi: 10.1111/1467-985X.00156 – ident: e_1_2_7_45_1 doi: 10.1902/jop.1999.70.6.567 – ident: e_1_2_7_16_1 doi: 10.1034/j.1600-0765.2000.035002102.x – ident: e_1_2_7_36_1 doi: 10.1111/j.1600-051X.2007.01145.x – ident: e_1_2_7_2_1 doi: 10.1007/s007840100126 – ident: e_1_2_7_9_1 doi: 10.1111/j.1600-051X.1997.tb01187.x – ident: e_1_2_7_17_1 doi: 10.1007/s00784-007-0120-5 – ident: e_1_2_7_32_1 doi: 10.1902/jop.2004.75.1.16 – ident: e_1_2_7_15_1 doi: 10.1902/jop.2005.76.1.49 – ident: e_1_2_7_27_1 doi: 10.1177/154405910308200308 – ident: e_1_2_7_34_1 doi: 10.1038/sj.gene.6363882 – ident: e_1_2_7_29_1 doi: 10.1902/jop.2003.74.12.1796 – ident: e_1_2_7_10_1 doi: 10.1902/jop.2000.71.2.156 – ident: e_1_2_7_11_1 doi: 10.1902/jop.1999.70.1.49 – ident: e_1_2_7_30_1 doi: 10.1016/S0198-8859(02)00440-8 – ident: e_1_2_7_7_1 doi: 10.1111/j.1600-051x.2004.00477.x – ident: e_1_2_7_21_1 – ident: e_1_2_7_48_1 doi: 10.1007/s00784-006-0067-y – ident: e_1_2_7_6_1 doi: 10.1007/s007840000078 – ident: e_1_2_7_44_1 doi: 10.1177/00220345000790110801 – ident: e_1_2_7_12_1 doi: 10.1902/jop.2005.76.2.234 – ident: e_1_2_7_40_1 doi: 10.1111/j.1600-051X.1986.tb00881.x – ident: e_1_2_7_14_1 doi: 10.1034/j.1600-051X.2003.00218.x – ident: e_1_2_7_35_1 doi: 10.1111/j.1600-051X.2004.00479.x – ident: e_1_2_7_18_1 doi: 10.1111/j.1600-0765.1999.tb02265.x – ident: e_1_2_7_22_1 doi: 10.1007/s00784-005-0001-8 – ident: e_1_2_7_38_1 doi: 10.1111/j.1600-051X.1975.tb01722.x – ident: e_1_2_7_5_1 doi: 10.1111/j.1600-051x.2004.00478.x – volume: 45 start-page: 499 year: 1999 ident: e_1_2_7_24_1 article-title: Reverse hybridization assay for rapid identification of periodontitis‐associated interleukin‐1 alleles publication-title: Clin Lab – ident: e_1_2_7_41_1 doi: 10.1111/j.1600-0765.2006.00951.x – ident: e_1_2_7_42_1 doi: 10.1034/j.1600-051x.2000.027011810.x – ident: e_1_2_7_43_1 doi: 10.1034/j.1600-051x.2001.028005389.x – ident: e_1_2_7_46_1 doi: 10.1111/j.1600-051X.2006.00993.x – ident: e_1_2_7_4_1 doi: 10.1111/j.1600-051X.1995.tb00818.x – ident: e_1_2_7_26_1 doi: 10.2307/2983328 – ident: e_1_2_7_19_1 doi: 10.1002/sim.1264 – ident: e_1_2_7_39_1 doi: 10.1111/j.1600-051X.1978.tb01903.x – ident: e_1_2_7_13_1 doi: 10.1016/j.ygeno.2008.07.004 – ident: e_1_2_7_33_1 doi: 10.1093/ajcn/83.2.475S
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Snippet	Background: We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)‐1A−889 and IL‐1B+3954 in an Arabic population... Background: We previously reported a high prevalence of a combination of alleles 2 at positions interleukin ( IL)‐1A −889 and IL‐1B +3954 in an Arabic... We previously reported a high prevalence of a combination of alleles 2 at positions interleukin (IL)-1A(-889) and IL-1B(+3954) in an Arabic population with...
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SubjectTerms	Adult Arabs - genetics Biological and medical sciences Dental plaque Dental Plaque - physiopathology Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Genetic Predisposition to Disease Gingival Hemorrhage - etiology Gingival Hemorrhage - genetics gingivitis Gingivitis - complications Gingivitis - genetics Humans Interleukin-1alpha - genetics Interleukin-1beta - genetics interleukin‐1 Male Medical sciences Multilevel Analysis multivariate analysis Non tumoral diseases Otorhinolaryngology. Stomatology Periodontal Index Polymorphism, Genetic Reference Values Young Adult
Title	Site‐Specific Gingival Bleeding on Probing in a Steady‐State Plaque Environment: Influence of Polymorphisms in the Interleukin‐1 Gene Cluster
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