Treatment-resistant depression with anhedonia: Integrating clinical and preclinical approaches to investigate distinct phenotypes

In our clinical work with treatment-resistant depressed (TRD) patients, certain patterns have emerged in terms of patients’ presentations of anhedonia. Multiple studies have investigated anhedonia either as a state or a trait variable in depression, but anhedonia is a multifaceted construct and, as...

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Bibliographic Details
Published in:	Neuroscience and biobehavioral reviews Vol. 136; p. 104578
Main Authors:	Kelly, Chris A., Freeman, Kevin B., Schumacher, Julie A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.05.2022
Subjects:	Anhedonia Animals Case studies Depression - drug therapy Depressive Disorder, Treatment-Resistant - drug therapy Endophenotypes Humans Major depressive disorder Phenotype Preclinical models Translational Treatment Outcome Treatment resistant depression Case studies Treatment resistant depression Endophenotypes Anhedonia Translational Preclinical models Major depressive disorder
ISSN:	0149-7634, 1873-7528, 1873-7528
Online Access:	Get full text
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