White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies

•WMHs conferred a 14 % elevated risk of cognitive impairment and ACD.•WMHs increased both AD risk and VaD risk.•Periventricular WMH were related with increased risk of ACD.•The dose-response analysis showed a nonlinear association between WMHs and ACD. White matter hyperintensities of presumed vascu...

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Veröffentlicht in:	Neuroscience and biobehavioral reviews Jg. 120; S. 16 - 27
Hauptverfasser:	Hu, He-Ying, Ou, Ya-Nan, Shen, Xue-Ning, Qu, Yi, Ma, Ya-Hui, Wang, Zuo-Teng, Dong, Qiang, Tan, Lan, Yu, Jin-Tai
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Ltd 01.01.2021
Schlagworte:	Alzheimer’s disease Cerebral small vessel disease Cerebral Small Vessel Diseases Cognition Cognitive Dysfunction Dementia Dementia, Vascular - diagnostic imaging Dose-response Humans Magnetic Resonance Imaging Meta-analysis Prospective Studies White Matter - diagnostic imaging White matter hyperintensities White matter hyperintensities Alzheimer’s disease Dose-response Cognition Cerebral small vessel disease Dementia Meta-analysis
ISSN:	0149-7634, 1873-7528, 1873-7528
Online-Zugang:	Volltext
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