White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies
•WMHs conferred a 14 % elevated risk of cognitive impairment and ACD.•WMHs increased both AD risk and VaD risk.•Periventricular WMH were related with increased risk of ACD.•The dose-response analysis showed a nonlinear association between WMHs and ACD. White matter hyperintensities of presumed vascu...
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| Vydáno v: | Neuroscience and biobehavioral reviews Ročník 120; s. 16 - 27 |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Elsevier Ltd
01.01.2021
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| Témata: | |
| ISSN: | 0149-7634, 1873-7528, 1873-7528 |
| On-line přístup: | Získat plný text |
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| Abstract | •WMHs conferred a 14 % elevated risk of cognitive impairment and ACD.•WMHs increased both AD risk and VaD risk.•Periventricular WMH were related with increased risk of ACD.•The dose-response analysis showed a nonlinear association between WMHs and ACD.
White matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. This meta-analysis aimed to identify the associations of WMH with risks of cognitive impairment and dementia.
We searched PubMed, EMBASE and Cochrane Library for prospective studies. Primary analyses of cognitive dysfunction and sub-analyses of specific outcomes and study characteristics were conducted using random-effect models.
Thirty-six prospective studies with 19,040 participants were included. WMH at baseline conferred a 14 % elevated risk of cognitive impairment and all-cause dementia (ACD). WMH also conferred 25 % elevated risk of Alzheimer’s disease and 73 % elevated risk of vascular dementia. Risk effects of high-grade WMH and continually increasing WMH (in volume or severity) on ACD were revealed. Periventricular WMH conferred a 1.51-fold excess risk for dementia.
WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia. |
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| AbstractList | White matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. This meta-analysis aimed to identify the associations of WMH with risks of cognitive impairment and dementia.
We searched PubMed, EMBASE and Cochrane Library for prospective studies. Primary analyses of cognitive dysfunction and sub-analyses of specific outcomes and study characteristics were conducted using random-effect models.
Thirty-six prospective studies with 19,040 participants were included. WMH at baseline conferred a 14 % elevated risk of cognitive impairment and all-cause dementia (ACD). WMH also conferred 25 % elevated risk of Alzheimer's disease and 73 % elevated risk of vascular dementia. Risk effects of high-grade WMH and continually increasing WMH (in volume or severity) on ACD were revealed. Periventricular WMH conferred a 1.51-fold excess risk for dementia.
WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia. White matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. This meta-analysis aimed to identify the associations of WMH with risks of cognitive impairment and dementia.BACKGROUNDWhite matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. This meta-analysis aimed to identify the associations of WMH with risks of cognitive impairment and dementia.We searched PubMed, EMBASE and Cochrane Library for prospective studies. Primary analyses of cognitive dysfunction and sub-analyses of specific outcomes and study characteristics were conducted using random-effect models.METHODSWe searched PubMed, EMBASE and Cochrane Library for prospective studies. Primary analyses of cognitive dysfunction and sub-analyses of specific outcomes and study characteristics were conducted using random-effect models.Thirty-six prospective studies with 19,040 participants were included. WMH at baseline conferred a 14 % elevated risk of cognitive impairment and all-cause dementia (ACD). WMH also conferred 25 % elevated risk of Alzheimer's disease and 73 % elevated risk of vascular dementia. Risk effects of high-grade WMH and continually increasing WMH (in volume or severity) on ACD were revealed. Periventricular WMH conferred a 1.51-fold excess risk for dementia.RESULTSThirty-six prospective studies with 19,040 participants were included. WMH at baseline conferred a 14 % elevated risk of cognitive impairment and all-cause dementia (ACD). WMH also conferred 25 % elevated risk of Alzheimer's disease and 73 % elevated risk of vascular dementia. Risk effects of high-grade WMH and continually increasing WMH (in volume or severity) on ACD were revealed. Periventricular WMH conferred a 1.51-fold excess risk for dementia.WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia.CONCLUSIONSWMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia. •WMHs conferred a 14 % elevated risk of cognitive impairment and ACD.•WMHs increased both AD risk and VaD risk.•Periventricular WMH were related with increased risk of ACD.•The dose-response analysis showed a nonlinear association between WMHs and ACD. White matter hyperintensities of presumed vascular origin (WMH) are one of the imaging features of cerebral small vessel disease. Controversies persist about the effects of WMH on cognitive dysfunction. This meta-analysis aimed to identify the associations of WMH with risks of cognitive impairment and dementia. We searched PubMed, EMBASE and Cochrane Library for prospective studies. Primary analyses of cognitive dysfunction and sub-analyses of specific outcomes and study characteristics were conducted using random-effect models. Thirty-six prospective studies with 19,040 participants were included. WMH at baseline conferred a 14 % elevated risk of cognitive impairment and all-cause dementia (ACD). WMH also conferred 25 % elevated risk of Alzheimer’s disease and 73 % elevated risk of vascular dementia. Risk effects of high-grade WMH and continually increasing WMH (in volume or severity) on ACD were revealed. Periventricular WMH conferred a 1.51-fold excess risk for dementia. WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia. |
| Author | Hu, He-Ying Wang, Zuo-Teng Ma, Ya-Hui Tan, Lan Qu, Yi Dong, Qiang Ou, Ya-Nan Yu, Jin-Tai Shen, Xue-Ning |
| Author_xml | – sequence: 1 givenname: He-Ying surname: Hu fullname: Hu, He-Ying organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China – sequence: 2 givenname: Ya-Nan surname: Ou fullname: Ou, Ya-Nan organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China – sequence: 3 givenname: Xue-Ning surname: Shen fullname: Shen, Xue-Ning organization: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China – sequence: 4 givenname: Yi surname: Qu fullname: Qu, Yi organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China – sequence: 5 givenname: Ya-Hui surname: Ma fullname: Ma, Ya-Hui organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China – sequence: 6 givenname: Zuo-Teng surname: Wang fullname: Wang, Zuo-Teng organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China – sequence: 7 givenname: Qiang surname: Dong fullname: Dong, Qiang organization: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China – sequence: 8 givenname: Lan surname: Tan fullname: Tan, Lan email: dr.tanlan@163.com organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China – sequence: 9 givenname: Jin-Tai surname: Yu fullname: Yu, Jin-Tai email: yu-jintai@163.com organization: Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33188821$$D View this record in MEDLINE/PubMed |
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| Keywords | White matter hyperintensities Alzheimer’s disease Dose-response Cognition Cerebral small vessel disease Dementia Meta-analysis |
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| SubjectTerms | Alzheimer’s disease Cerebral small vessel disease Cerebral Small Vessel Diseases Cognition Cognitive Dysfunction Dementia Dementia, Vascular - diagnostic imaging Dose-response Humans Magnetic Resonance Imaging Meta-analysis Prospective Studies White Matter - diagnostic imaging White matter hyperintensities |
| Title | White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies |
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