Bone marrow-mesenchymal stem cells alleviate microglial Pyroptosis after intracerebral hemorrhage in rat by secreting C1q/tumor necrosis factor-related protein 3

There are no specific treatment methods for intracerebral hemorrhage (ICH). Neuroinflammation triggered by microglial pyroptosis plays an important role in ICH pathophysiology. Bone marrow mesenchymal stem cells (BMSCs) are widely used in the treatment of neurological diseases because of their parac...

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Bibliographic Details
Published in:	Experimental neurology Vol. 364; p. 114387
Main Authors:	Wang, Qinghua, Piao, Jifeng, Li, Yulong, Tu, Huiru, Lv, Dingyi, Hu, Libin, Zhang, Run, Zhong, Zhenzhong
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2023
Subjects:	Animals Bone Marrow - metabolism Bone marrow mesenchymal stem cells c1q/tumor necrosis factor-related protein 3 Cerebral Hemorrhage - metabolism Complement C1q - metabolism Hemin - metabolism Hemin - pharmacology Inflammation - metabolism Intracerebral hemorrhage Mesenchymal Stem Cells - metabolism Microglia Microglia - metabolism Neuroinflammation Neuroinflammatory Diseases Phosphatidylinositol 3-Kinases - metabolism PI3K / AKT signaling pathway Proto-Oncogene Proteins c-akt - metabolism Pyroptosis Rats RNA, Small Interfering - metabolism Syk signaling pathway Tumor Necrosis Factors - metabolism Pyroptosis Bone marrow mesenchymal stem cells Neuroinflammation PI3K / AKT signaling pathway c1q/tumor necrosis factor-related protein 3 Syk signaling pathway Intracerebral hemorrhage Microglia
ISSN:	0014-4886, 1090-2430, 1090-2430
Online Access:	Get full text
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