Simple algorithm derived from a geno-/phenotypic database to predict HIV-1 protease inhibitor resistance

Resistance against protease inhibitors (PI) can either be analysed genotypically or phenotypically. However, the interpretation of genotypic data is difficult, particularly for PI, because of the unknown contributions of several mutations to resistance and cross-resistance. Development of an algorit...

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Vydané v:	AIDS (London) Ročník 14; číslo 12; s. 1731
Hlavní autori:	Schmidt, B, Walter, H, Moschik, B, Paatz, C, van Vaerenbergh, K, Vandamme, A M, Schmitt, M, Harrer, T, Uberla, K, Korn, K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 18.08.2000
Predmet:	Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - virology Algorithms Databases, Factual Drug Resistance, Microbial - genetics Genotype HIV Protease Inhibitors - pharmacology HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - genetics Humans Molecular Sequence Data Phenotype Point Mutation Sensitivity and Specificity
ISSN:	0269-9370
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