Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples
The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in tumoral zones were measured and compared usin...
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| Veröffentlicht in: | PloS one Jg. 14; H. 1; S. e0210905 |
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| Sprache: | Englisch |
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2019
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in tumoral zones were measured and compared using tissue micro-imaging with a beta imager on 14 breast cancer samples (10 primaries and 4 associated metastatic lymph nodes). Results were then assessed against ER expression, progesterone receptor (PR) expression, HER2 over-expression or not and Ki-67 expression. GRPR immunohistochemistry (IHC) was also performed on all samples. We also retrospectively compared 68Ga-RM2 and 18F-FDG bindings to 18F-FDG SUVmax on the pre-therapeutic PET/CT examination, if available. 68Ga-RM2 binding was significantly higher in tumors expressing GRPR on IHC than in GRPR-negative tumors (P = 0.022). In ER+ tumors, binding of 68Ga-RM2 was significantly higher than 18F-FDG (P = 0.015). In tumors with low Ki-67, 68Ga-RM2 binding was also significantly increased compared to 18F-FDG (P = 0.029). Overall, the binding of 68Ga-RM2 and 18F-FDG displayed an opposite pattern in tumor samples and 68Ga-RM2 binding was significantly higher in tumors that had low 18F-FDG binding (P = 0.021). This inverse correlation was also documented in the few patients in whom a 18F-FDG PET/CT examination before surgery was available. Findings from this in vitro study suggest that GRPR targeting can be an alternative to 18F-FDG imaging in ER+ breast tumors. Moreover, because GRPR antagonists can also be labeled with lutetium-177 this opens new avenues for targeted radionuclide therapy in the subset of patients with progressive metastatic disease following conventional treatments. |
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| AbstractList | The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in tumoral zones were measured and compared using tissue micro-imaging with a beta imager on 14 breast cancer samples (10 primaries and 4 associated metastatic lymph nodes). Results were then assessed against ER expression, progesterone receptor (PR) expression, HER2 over-expression or not and Ki-67 expression. GRPR immunohistochemistry (IHC) was also performed on all samples. We also retrospectively compared 68Ga-RM2 and 18F-FDG bindings to 18F-FDG SUVmax on the pre-therapeutic PET/CT examination, if available. 68Ga-RM2 binding was significantly higher in tumors expressing GRPR on IHC than in GRPR-negative tumors (P = 0.022). In ER+ tumors, binding of 68Ga-RM2 was significantly higher than 18F-FDG (P = 0.015). In tumors with low Ki-67, 68Ga-RM2 binding was also significantly increased compared to 18F-FDG (P = 0.029). Overall, the binding of 68Ga-RM2 and 18F-FDG displayed an opposite pattern in tumor samples and 68Ga-RM2 binding was significantly higher in tumors that had low 18F-FDG binding (P = 0.021). This inverse correlation was also documented in the few patients in whom a 18F-FDG PET/CT examination before surgery was available. Findings from this in vitro study suggest that GRPR targeting can be an alternative to 18F-FDG imaging in ER+ breast tumors. Moreover, because GRPR antagonists can also be labeled with lutetium-177 this opens new avenues for targeted radionuclide therapy in the subset of patients with progressive metastatic disease following conventional treatments. The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in tumoral zones were measured and compared using tissue micro-imaging with a beta imager on 14 breast cancer samples (10 primaries and 4 associated metastatic lymph nodes). Results were then assessed against ER expression, progesterone receptor (PR) expression, HER2 over-expression or not and Ki-67 expression. GRPR immunohistochemistry (IHC) was also performed on all samples. We also retrospectively compared 68Ga-RM2 and 18F-FDG bindings to 18F-FDG SUVmax on the pre-therapeutic PET/CT examination, if available. 68Ga-RM2 binding was significantly higher in tumors expressing GRPR on IHC than in GRPR-negative tumors (P = 0.022). In ER+ tumors, binding of 68Ga-RM2 was significantly higher than 18F-FDG (P = 0.015). In tumors with low Ki-67, 68Ga-RM2 binding was also significantly increased compared to 18F-FDG (P = 0.029). Overall, the binding of 68Ga-RM2 and 18F-FDG displayed an opposite pattern in tumor samples and 68Ga-RM2 binding was significantly higher in tumors that had low 18F-FDG binding (P = 0.021). This inverse correlation was also documented in the few patients in whom a 18F-FDG PET/CT examination before surgery was available. Findings from this in vitro study suggest that GRPR targeting can be an alternative to 18F-FDG imaging in ER+ breast tumors. Moreover, because GRPR antagonists can also be labeled with lutetium-177 this opens new avenues for targeted radionuclide therapy in the subset of patients with progressive metastatic disease following conventional treatments.The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in tumoral zones were measured and compared using tissue micro-imaging with a beta imager on 14 breast cancer samples (10 primaries and 4 associated metastatic lymph nodes). Results were then assessed against ER expression, progesterone receptor (PR) expression, HER2 over-expression or not and Ki-67 expression. GRPR immunohistochemistry (IHC) was also performed on all samples. We also retrospectively compared 68Ga-RM2 and 18F-FDG bindings to 18F-FDG SUVmax on the pre-therapeutic PET/CT examination, if available. 68Ga-RM2 binding was significantly higher in tumors expressing GRPR on IHC than in GRPR-negative tumors (P = 0.022). In ER+ tumors, binding of 68Ga-RM2 was significantly higher than 18F-FDG (P = 0.015). In tumors with low Ki-67, 68Ga-RM2 binding was also significantly increased compared to 18F-FDG (P = 0.029). Overall, the binding of 68Ga-RM2 and 18F-FDG displayed an opposite pattern in tumor samples and 68Ga-RM2 binding was significantly higher in tumors that had low 18F-FDG binding (P = 0.021). This inverse correlation was also documented in the few patients in whom a 18F-FDG PET/CT examination before surgery was available. Findings from this in vitro study suggest that GRPR targeting can be an alternative to 18F-FDG imaging in ER+ breast tumors. Moreover, because GRPR antagonists can also be labeled with lutetium-177 this opens new avenues for targeted radionuclide therapy in the subset of patients with progressive metastatic disease following conventional treatments. |
| Author | Vimont, Delphine Fernandez, Philippe Hindié, Elif Macgrogan, Gaétan Barthe, Nicole Morgat, Clément Schollhammer, Romain Vélasco, Valérie Cazeau, Anne-Laure |
| AuthorAffiliation | 5 INSERM, ACTION U1218, Bordeaux, France 2 Univ. Bordeaux, INCIA, UMR-CNRS 5287, Talence, France 4 Surgical Pathology Unit, Department of BioPathology, Institut Bergonié, Bordeaux, France 6 BioTis, INSERM U1026, Bordeaux, France 3 CNRS, INCIA, UMR 5287, Talence, France University of South Alabama Mitchell Cancer Institute, UNITED STATES 7 Nuclear Medicine Department, Institut Bergonié, Bordeaux, France 1 Nuclear Medicine Department, University Hospital of Bordeaux, Bordeaux, France |
| AuthorAffiliation_xml | – name: 1 Nuclear Medicine Department, University Hospital of Bordeaux, Bordeaux, France – name: 5 INSERM, ACTION U1218, Bordeaux, France – name: 4 Surgical Pathology Unit, Department of BioPathology, Institut Bergonié, Bordeaux, France – name: 2 Univ. Bordeaux, INCIA, UMR-CNRS 5287, Talence, France – name: 6 BioTis, INSERM U1026, Bordeaux, France – name: 3 CNRS, INCIA, UMR 5287, Talence, France – name: 7 Nuclear Medicine Department, Institut Bergonié, Bordeaux, France – name: University of South Alabama Mitchell Cancer Institute, UNITED STATES |
| Author_xml | – sequence: 1 givenname: Clément orcidid: 0000-0002-9432-9223 surname: Morgat fullname: Morgat, Clément – sequence: 2 givenname: Romain surname: Schollhammer fullname: Schollhammer, Romain – sequence: 3 givenname: Gaétan surname: Macgrogan fullname: Macgrogan, Gaétan – sequence: 4 givenname: Nicole surname: Barthe fullname: Barthe, Nicole – sequence: 5 givenname: Valérie surname: Vélasco fullname: Vélasco, Valérie – sequence: 6 givenname: Delphine surname: Vimont fullname: Vimont, Delphine – sequence: 7 givenname: Anne-Laure surname: Cazeau fullname: Cazeau, Anne-Laure – sequence: 8 givenname: Philippe surname: Fernandez fullname: Fernandez, Philippe – sequence: 9 givenname: Elif surname: Hindié fullname: Hindié, Elif |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30645633$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.7150/thno.14958 10.1007/s00259-015-3232-1 10.1097/RLU.0000000000002209 10.1007/s00259-013-2616-3 10.1021/bi900521n 10.1093/annonc/mdt303 10.2967/jnumed.115.170423 10.2967/jnumed.116.188011 10.2967/jnumed.112.107540 10.2967/jnumed.114.142000 10.7150/thno.22601 10.2967/jnumed.112.112169 10.1186/bcr3679 10.1200/JCO.2013.50.9984 10.2967/jnumed.115.160739 10.2967/jnumed.115.157859 |
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| Copyright | 2019 Morgat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 Morgat et al 2019 Morgat et al |
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| References | A Goldhirsch (ref8) 2013; 24 J Zang (ref6) 2018; 43 RA Dumont (ref13) 2013; 54 C Stoykow (ref5) 2016; 6 P Maisonneuve (ref9) 2014; 16 AC Wolff (ref7) 2013; 31 E Hindié (ref15) 2016; 57 J Zhang (ref12) 2018; 8 C Morgat (ref1) 2014; 55 SU Dalm (ref3) 2015; 56 M Mueckler (ref16) 2009; 48 C Müller (ref14) 2012; 53 C Morgat (ref2) 2017; 58 O Humbert (ref11) 2014; 41 T Maina (ref4) 2016; 43 D Groheux (ref10) 2016; 57 |
| References_xml | – volume: 6 start-page: 1641 issue: 10 year: 2016 ident: ref5 article-title: Gastrin-releasing Peptide Receptor Imaging in Breast Cancer Using the Receptor Antagonist 68Ga-RM2 And PET publication-title: Theranostics doi: 10.7150/thno.14958 – volume: 43 start-page: 964 issue: 5 year: 2016 ident: ref4 article-title: Preclinical and first clinical experience with the gastrin-releasing peptide receptor-antagonist [68Ga]SB3 and PET/CT publication-title: Eur J Nucl Med Mol Imaging doi: 10.1007/s00259-015-3232-1 – volume: 43 start-page: 663 issue: 9 year: 2018 ident: ref6 article-title: 68Ga-NOTA-RM26 PET/CT in the Evaluation of Breast Cancer: A Pilot Prospective Study publication-title: Clin Nucl Med doi: 10.1097/RLU.0000000000002209 – volume: 41 start-page: 416 issue: 3 year: 2014 ident: ref11 article-title: Prognostic relevance at 5 years of the early monitoring of neoadjuvant chemotherapy using 18F-FDG PET in luminal HER2-negative breast cancer publication-title: Eur J Nucl Med Mol Imaging doi: 10.1007/s00259-013-2616-3 – volume: 48 start-page: 5934 issue: 25 year: 2009 ident: ref16 article-title: Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesis publication-title: Biochemistry doi: 10.1021/bi900521n – volume: 24 start-page: 2206 issue: 9 year: 2013 ident: ref8 article-title: Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 publication-title: Ann Oncol doi: 10.1093/annonc/mdt303 – volume: 57 start-page: 759 issue: 5 year: 2016 ident: ref15 article-title: Dose Deposits from 90Y, 177Lu, 111In, and 161Tb in Micrometastases of Various Sizes: Implications for Radiopharmaceutical Therapy publication-title: J Nucl Med doi: 10.2967/jnumed.115.170423 – volume: 58 start-page: 1401 issue: 9 year: 2017 ident: ref2 article-title: Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters: A Study of 1,432 Primary Tumors publication-title: J Nucl Med doi: 10.2967/jnumed.116.188011 – volume: 53 start-page: 1951 issue: 12 year: 2012 ident: ref14 article-title: A unique matched quadruplet of terbium radioisotopes for PET and SPECT and for α- and β- radionuclide therapy: an in vivo proof-of-concept study with a new receptor-targeted folate derivative publication-title: J Nucl Med doi: 10.2967/jnumed.112.107540 – volume: 55 start-page: 1650 issue: 10 year: 2014 ident: ref1 article-title: Targeting neuropeptide receptors for cancer imaging and therapy: perspectives with bombesin, neurotensin, and neuropeptide-Y receptors publication-title: J Nucl Med doi: 10.2967/jnumed.114.142000 – volume: 8 start-page: 1121 issue: 4 year: 2018 ident: ref12 article-title: 68Ga-BBN-RGD PET/CT for GRPR and Integrin αvβ3 Imaging in Patients with Breast Cancer publication-title: Theranostics doi: 10.7150/thno.22601 – volume: 54 start-page: 762 issue: 5 year: 2013 ident: ref13 article-title: Targeted radiotherapy of prostate cancer with a gastrin-releasing peptide receptor antagonist is effective as monotherapy and in combination with rapamycin publication-title: J Nucl Med doi: 10.2967/jnumed.112.112169 – volume: 16 start-page: R65 issue: 3 year: 2014 ident: ref9 article-title: Proposed new clinicopathological surrogate definitions of luminal A and luminal B (HER2-negative) intrinsic breast cancer subtypes publication-title: Breast Cancer Res doi: 10.1186/bcr3679 – volume: 31 start-page: 3997 issue: 31 year: 2013 ident: ref7 article-title: Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update publication-title: J Clin Oncol doi: 10.1200/JCO.2013.50.9984 – volume: 56 start-page: 1487 issue: 10 year: 2015 ident: ref3 article-title: Clinical Relevance of Targeting the Gastrin-Releasing Peptide Receptor, Somatostatin Receptor 2, or Chemokine C-X-C Motif Receptor 4 in Breast Cancer for Imaging and Therapy publication-title: J Nucl Med doi: 10.2967/jnumed.115.160739 – volume: 57 start-page: 17S issue: Suppl 1 year: 2016 ident: ref10 article-title: 18F-FDG PET/CT for Staging and Restaging of Breast Cancer publication-title: J Nucl Med doi: 10.2967/jnumed.115.157859 |
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| Title | Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples |
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