Comparison of the effects of several potassium-channel openers on rat bladder and rat portal vein in vitro

1. The ability of several K-channel openers to inhibit KCl-induced contractions of rat bladder detrusor and spontaneous mechanical activity in rat portal vein was examined. 2. Lemakalim, pinacidil, Ro 31-6930, RP 49356, P1060 and S 0121 dose-dependently relaxed rat detrusor, precontracted with 20 mM...

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Vydané v:	British journal of pharmacology Ročník 102; číslo 3; s. 679
Hlavní autori:	Edwards, G, Henshaw, M, Miller, M, Weston, A H
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.03.1991
Predmet:	Animals Benzopyrans - pharmacology Cromakalim Glyburide - pharmacology Guanidines - pharmacology In Vitro Techniques Male Pinacidil Portal Vein - drug effects Portal Vein - physiology Potassium - metabolism Potassium Channels - drug effects Pyrroles - pharmacology Rats Rats, Sprague-Dawley Urinary Bladder - drug effects Urinary Bladder - physiology
ISSN:	0007-1188
On-line prístup:	Zistit podrobnosti o prístupe
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