A novel synthetised sulphonylhydrazone coumarin (E)‐4‐methyl‐N′‐(1‐(3‐oxo‐3H‐benzo[f]chromen‐2‐ yl)ethylidene)benzenesulphonohydrazide protect against isoproterenol‐induced myocardial infarction in rats by attenuating oxidative damage, biological changes and electrocardiogram

Coumarins and their derivatives are becoming a potential source for new drug discovery due to their vast array of biological activities. The present study was designed to investigate the cardioprotective effects of a newly synthesised coumarin, symbolised as 5,6‐PhSHC, against cardiac remodelling pr...

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Bibliographic Details
Published in:	Clinical and experimental pharmacology & physiology Vol. 49; no. 9; pp. 1010 - 1026
Main Authors:	Ghazouani, Lakhdar, Khdhiri, Emna, Elmufti, Afoua, Zarei, Armin, Feriani, Anouar, Baaziz, Intissar, Hajji, Raouf, Abid, Majdi, Ammar, Houcine, Abid, Souhir, Allouche, Noureddine, Mnafgui, Kais, Ramazani, Ali, Tlili, Nizar
Format:	Journal Article
Language:	English
Published:	Australia Wiley Subscription Services, Inc 01.09.2022
Subjects:	Animals Antioxidants - metabolism Biomarkers Body Weight Calcium-binding protein cardioprotective activity Cardiotonic Agents - adverse effects Catalase Catalase - metabolism Cholesterol Clopidogrel Computer applications Coumarin coumarin derivative Coumarins - pharmacology Coumarins - therapeutic use Creatine Creatine kinase Damage prevention Drug development EKG Electrocardiography Fibrinogen Glutathione Glutathione - metabolism Glycoproteins Heart Heart attacks Inflammation Injection Injury prevention Isoproterenol Isoproterenol - adverse effects Kinases L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Male molecular docking Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - drug therapy Myocardial Infarction - prevention & control Myocardium Myocardium - metabolism Necrosis Oxidative Stress Plasma levels Prostaglandin endoperoxide synthase Rats Rats, Wistar Reductases Superoxide dismutase Triglycerides Troponin cardioprotective activity molecular docking myocardial infarction isoproterenol coumarin derivative oxidative stress electrocardiography
ISSN:	0305-1870, 1440-1681, 1440-1681
Online Access:	Get full text
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