APDCA: An accurate and effective method for predicting associations between RBPs and AS-events during epithelial-mesenchymal transition

Motivation: Epithelial-mesenchymal transition (EMT) plays a key role in cancer metastasis by promoting changes in adhesion and motility. RNA-binding proteins (RBPs) regulate alternative splicing (AS) during EMT, enabling a single gene to produce multiple protein isoforms that affect tumor progressio...

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Bibliographic Details

Published in:	PLoS computational biology Vol. 21; no. 11; p. e1013665
Main Authors:	He, Yangsong, Bai, Zheng-Jian, Ching, Wai-Ki, Zou, Quan, Qiu, Yushan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science (PLoS) 01.11.2025
Subjects:	Algorithms Alternative Splicing - genetics Computational Biology - methods Epithelial-Mesenchymal Transition - genetics Humans Neoplasms - genetics Neoplasms - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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