Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

Regulatory T (T reg ) cells exhibit substantial phenotypic and functional plasticity. Hiroshi Takayanagi and his colleagues report that in autoimmune arthritis, a subset of T reg cells can lose Foxp3 expression and convert into T H 17 cells. This conversion is mediated by synovial fibroblast-derived...

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Bibliographic Details
Published in:	Nature medicine Vol. 20; no. 1; pp. 62 - 68
Main Authors:	Komatsu, Noriko, Okamoto, Kazuo, Sawa, Shinichiro, Nakashima, Tomoki, Oh-hora, Masatsugu, Kodama, Tatsuhiko, Tanaka, Sakae, Bluestone, Jeffrey A, Takayanagi, Hiroshi
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.01.2014 Nature Publishing Group
Subjects:	631/250/38 Adoptive Transfer Animals Antigens Arthritis Arthritis - immunology Autoimmune diseases Autoimmune Diseases - immunology Biomedical materials Biomedicine Cancer Research CCL20 protein CCR6 protein CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - immunology Cell fate Chemokines Collagen Conversion Cytokines Fate maps Flow Cytometry Forkhead Transcription Factors - immunology Forkhead Transcription Factors - metabolism Foxp3 protein Gene Knock-In Techniques Helper cells Humans Immunization Infectious Diseases Inflammation Interleukin 17 Interleukin 23 Interleukin 6 Joint diseases Ligands Lymphocytes Lymphocytes T Mapping Metabolic Diseases Mice Mice, Inbred C57BL Molecular Medicine Neurosciences NF-κB protein Oligonucleotide Array Sequence Analysis Pathogenesis Rheumatoid arthritis Synovial Membrane - cytology Synovial Membrane - immunology Synovium T cell receptors Th17 Cells - cytology Th17 Cells - immunology TRANCE protein
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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