Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector
Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host’s autophagic machinery. Additionally, some viruses can hijack autophagy for their own benefit. However, the mechanisms underlying the transcriptional regulation of autophagy by ar...
Uloženo v:
| Vydáno v: | PLoS pathogens Ročník 21; číslo 10; s. e1013569 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science (PLoS)
01.10.2025
|
| Témata: | |
| ISSN: | 1553-7374, 1553-7366, 1553-7374 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host’s autophagic machinery. Additionally, some viruses can hijack autophagy for their own benefit. However, the mechanisms underlying the transcriptional regulation of autophagy by arboviruses in insect vectors remain largely unexplored. In this study, we found that rice dwarf virus (RDV) infection activates the autophagy pathway in the leafhopper vector, Nephotettix cincticeps , and this autophagy activation also facilitates viral infection in the leafhopper. We identified that MYC transcription factor regulates the expression of autophagy proteins ATG5 and ATG8 by directly targeting their promoters. A transcription regulator SMARCB1 binds to MYC and impedes its recognition of the ATG5 and ATG8 promoters, thus negatively regulating their expression. Moreover, NcSMARCB1 negatively regulates ATG5 expression by directly binding to its promoter. RDV major outer capsid protein P8 blocks the nuclear translocation of SMARCB1, disrupting the SMARCB1-MYC interaction and thereby relieving the transcriptional inhibition of ATG5 and ATG8, which leads to autophagy activation. Furthermore, major outer capsid protein P8 of rice gall dwarf virus (RGDV), same to RDV belonging to plant reoviruses, also interacts with SMARCB1 in leafhopper Recilia dorsalis , preventing its nuclear translocation. Similarly, suppression of SMARCB1 expression enhances autophagy formation and promotes RGDV infection. These findings highlight the critical role of insect vector SMARCB1 and MYC in regulating autophagy in response to arbovirus infection. |
|---|---|
| AbstractList | Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host's autophagic machinery. Additionally, some viruses can hijack autophagy for their own benefit. However, the mechanisms underlying the transcriptional regulation of autophagy by arboviruses in insect vectors remain largely unexplored. In this study, we found that rice dwarf virus (RDV) infection activates the autophagy pathway in the leafhopper vector, Nephotettix cincticeps, and this autophagy activation also facilitates viral infection in the leafhopper. We identified that MYC transcription factor regulates the expression of autophagy proteins ATG5 and ATG8 by directly targeting their promoters. A transcription regulator SMARCB1 binds to MYC and impedes its recognition of the ATG5 and ATG8 promoters, thus negatively regulating their expression. Moreover, NcSMARCB1 negatively regulates ATG5 expression by directly binding to its promoter. RDV major outer capsid protein P8 blocks the nuclear translocation of SMARCB1, disrupting the SMARCB1-MYC interaction and thereby relieving the transcriptional inhibition of ATG5 and ATG8, which leads to autophagy activation. Furthermore, major outer capsid protein P8 of rice gall dwarf virus (RGDV), same to RDV belonging to plant reoviruses, also interacts with SMARCB1 in leafhopper Recilia dorsalis, preventing its nuclear translocation. Similarly, suppression of SMARCB1 expression enhances autophagy formation and promotes RGDV infection. These findings highlight the critical role of insect vector SMARCB1 and MYC in regulating autophagy in response to arbovirus infection.Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host's autophagic machinery. Additionally, some viruses can hijack autophagy for their own benefit. However, the mechanisms underlying the transcriptional regulation of autophagy by arboviruses in insect vectors remain largely unexplored. In this study, we found that rice dwarf virus (RDV) infection activates the autophagy pathway in the leafhopper vector, Nephotettix cincticeps, and this autophagy activation also facilitates viral infection in the leafhopper. We identified that MYC transcription factor regulates the expression of autophagy proteins ATG5 and ATG8 by directly targeting their promoters. A transcription regulator SMARCB1 binds to MYC and impedes its recognition of the ATG5 and ATG8 promoters, thus negatively regulating their expression. Moreover, NcSMARCB1 negatively regulates ATG5 expression by directly binding to its promoter. RDV major outer capsid protein P8 blocks the nuclear translocation of SMARCB1, disrupting the SMARCB1-MYC interaction and thereby relieving the transcriptional inhibition of ATG5 and ATG8, which leads to autophagy activation. Furthermore, major outer capsid protein P8 of rice gall dwarf virus (RGDV), same to RDV belonging to plant reoviruses, also interacts with SMARCB1 in leafhopper Recilia dorsalis, preventing its nuclear translocation. Similarly, suppression of SMARCB1 expression enhances autophagy formation and promotes RGDV infection. These findings highlight the critical role of insect vector SMARCB1 and MYC in regulating autophagy in response to arbovirus infection. Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host’s autophagic machinery. Additionally, some viruses can hijack autophagy for their own benefit. However, the mechanisms underlying the transcriptional regulation of autophagy by arboviruses in insect vectors remain largely unexplored. In this study, we found that rice dwarf virus (RDV) infection activates the autophagy pathway in the leafhopper vector, Nephotettix cincticeps , and this autophagy activation also facilitates viral infection in the leafhopper. We identified that MYC transcription factor regulates the expression of autophagy proteins ATG5 and ATG8 by directly targeting their promoters. A transcription regulator SMARCB1 binds to MYC and impedes its recognition of the ATG5 and ATG8 promoters, thus negatively regulating their expression. Moreover, NcSMARCB1 negatively regulates ATG5 expression by directly binding to its promoter. RDV major outer capsid protein P8 blocks the nuclear translocation of SMARCB1, disrupting the SMARCB1-MYC interaction and thereby relieving the transcriptional inhibition of ATG5 and ATG8, which leads to autophagy activation. Furthermore, major outer capsid protein P8 of rice gall dwarf virus (RGDV), same to RDV belonging to plant reoviruses, also interacts with SMARCB1 in leafhopper Recilia dorsalis , preventing its nuclear translocation. Similarly, suppression of SMARCB1 expression enhances autophagy formation and promotes RGDV infection. These findings highlight the critical role of insect vector SMARCB1 and MYC in regulating autophagy in response to arbovirus infection. |
| Author | Wang, Hui Li, Bozhong Liu, Runfa Wei, Taiyun Xiao, Guangming Li, Yanan Chen, Qian |
| Author_xml | – sequence: 1 givenname: Hui surname: Wang fullname: Wang, Hui – sequence: 2 givenname: Runfa surname: Liu fullname: Liu, Runfa – sequence: 3 givenname: Guangming surname: Xiao fullname: Xiao, Guangming – sequence: 4 givenname: Yanan surname: Li fullname: Li, Yanan – sequence: 5 givenname: Bozhong surname: Li fullname: Li, Bozhong – sequence: 6 givenname: Qian surname: Chen fullname: Chen, Qian – sequence: 7 givenname: Taiyun orcidid: 0000-0002-0732-9752 surname: Wei fullname: Wei, Taiyun |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/41066408$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkctu2zAQRYkgQV7tHxQFl93IIUVKIpep0TYBEgRIs-mKGNFDm64sqiRlND_Rb678aNAVh4Mz9y7OFTntQ4-EfOBsxkXDb9ZhjD10s2GAPOOMi6rWJ-SSV5UoGtHI0__mC3KV0poxyQWvz8mF5KyuJVOX5M8zhq2PY8JEV34N9ifNK6TfH2-f55958fhjTnOEPtnoh-zDVEgjLscOdh9qw2bo8DfNgYLNfgsZKYw5DCtYvlIXIh0wJp8y9plONdO17x3a_bHvaYfgVmGYILqdtiG-I2cOuoTvj-81efn65WV-Vzw8fbuf3z4UVjQsF0rU7aJFAWDRWYeorELQqlRtKy2wVvNGl0pwx2phFWjmmsoxW3JmtWvENbk_xC4CrM0Q_QbiqwngzX4R4tJAzN52aEquGTAhdM2FVBx024p6n61LiVpMWZ8OWUMMv0ZM2Wx8sth10GMYkxFlpVVVlbKa0I9HdGw3uHgr_qdjAuQBsDGkFNG9IZyZnXVztG521s3RuvgL6dKldQ |
| Cites_doi | 10.1016/j.ymeth.2015.01.008 10.1016/S0021-9258(18)54636-6 10.1038/ncb2788 10.1099/vir.0.81425-0 10.1080/15548627.2021.1954773 10.1128/MCB.24.10.4476-4486.2004 10.1016/j.dci.2022.104406 10.1371/journal.ppat.1003032 10.1038/s41467-019-10022-5 10.1016/j.chom.2014.04.004 10.1126/science.1193497 10.1038/nature06639 10.1371/journal.ppat.1011134 10.1093/hmg/ddt381 10.1007/978-1-59745-157-4_4 10.1080/15548627.2016.1192749 10.1016/j.tibs.2014.02.003 10.1089/ars.2011.4394 10.1111/ajco.13449 10.1038/ng.3958 10.1371/journal.ppat.1006727 10.1146/annurev-phyto-080615-095900 10.1038/8811 10.1172/JCI62973 10.1111/j.1750-3639.1991.tb00058.x 10.1098/rstb.2018.0320 10.1080/15548627.2022.2091904 10.1038/s41419-023-06248-3 10.1128/JVI.02167-05 10.3390/cells2010083 10.1080/15548627.2022.2115830 10.1016/j.tim.2023.06.008 10.1080/15384101.2016.1146836 10.1073/pnas.1332764100 10.1074/jbc.M702824200 10.1038/nmicrobiol.2017.25 10.1038/nature18014 10.1016/j.cell.2010.01.028 10.3390/ijms22168527 10.1128/JVI.00050-07 10.14336/AD.2023.0520 10.7150/thno.34887 10.1016/j.cell.2014.11.006 10.2147/OTT.S210575 10.1080/15548627.2023.2200352 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2025 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Copyright_xml | – notice: Copyright: © 2025 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 DOA |
| DOI | 10.1371/journal.ppat.1013569 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Open Access: DOAJ - Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1553-7374 |
| ExternalDocumentID | oai_doaj_org_article_2190a0339613481a9bb3692831924e93 41066408 10_1371_journal_ppat_1013569 |
| Genre | Journal Article |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD EMK EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IHR INH INR ISN ISR ITC KQ8 LK8 M1P M48 M7P MM. O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PV9 QF4 QN7 RNS RPM RZL SV3 TR2 TUS UKHRP WOW ~8M ADRAZ CGR CUY CVF ECM EIF H13 IPNFZ NPM RIG WOQ 7X8 |
| ID | FETCH-LOGICAL-c370t-836bdbe3aacefcfee8c8ea9828bb4ca0b91792831f063c8a90f75f0c210c9f73 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 0 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001591829000009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1553-7374 1553-7366 |
| IngestDate | Mon Oct 20 20:00:30 EDT 2025 Sat Oct 11 06:38:02 EDT 2025 Mon Oct 13 01:40:49 EDT 2025 Sat Nov 29 07:18:01 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| License | Copyright: © 2025 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c370t-836bdbe3aacefcfee8c8ea9828bb4ca0b91792831f063c8a90f75f0c210c9f73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-0732-9752 |
| OpenAccessLink | https://doaj.org/article/2190a0339613481a9bb3692831924e93 |
| PMID | 41066408 |
| PQID | 3259855245 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2190a0339613481a9bb3692831924e93 proquest_miscellaneous_3259855245 pubmed_primary_41066408 crossref_primary_10_1371_journal_ppat_1013569 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-10-01 |
| PublicationDateYYYYMMDD | 2025-10-01 |
| PublicationDate_xml | – month: 10 year: 2025 text: 2025-10-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | PLoS pathogens |
| PublicationTitleAlternate | PLoS Pathog |
| PublicationYear | 2025 |
| Publisher | Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science (PLoS) |
| References | SW Cheng (ppat.1013569.ref033) 1999; 22 L-L Wang (ppat.1013569.ref020) 2016; 12 L Esteban-Martínez (ppat.1013569.ref006) 2015; 75 Y Chen (ppat.1013569.ref022) 2017; 13 S Pankiv (ppat.1013569.ref036) 2007; 282 C Chen (ppat.1013569.ref012) 2022; 132 H Li (ppat.1013569.ref040) 2019; 9 X Li (ppat.1013569.ref011) 2023; 19 T Wei (ppat.1013569.ref039) 2016; 54 AI Chiramel (ppat.1013569.ref034) 2013; 2 LS Hart (ppat.1013569.ref044) 2012; 122 W Wu (ppat.1013569.ref031) 2019; 374 PPC Toh (ppat.1013569.ref045) 2013; 22 P Boya (ppat.1013569.ref004) 2013; 15 IP Nezis (ppat.1013569.ref035) 2012; 17 KI Chan (ppat.1013569.ref015) 2024; 15 D Jia (ppat.1013569.ref030) 2017; 2 RT Nakayama (ppat.1013569.ref046) 2017; 49 Q Chen (ppat.1013569.ref025) 2023; 19 N Mizushima (ppat.1013569.ref009) 2008; 451 Z Berkova (ppat.1013569.ref038) 2006; 80 W Liu (ppat.1013569.ref019) 2023; 31 A Stojanova (ppat.1013569.ref049) 2016; 15 M Li (ppat.1013569.ref013) 2021; 54 AM Weissmiller (ppat.1013569.ref048) 2019; 10 Q Chen (ppat.1013569.ref028) 2012; 8 Z Li (ppat.1013569.ref016) 2003; 100 T Wei (ppat.1013569.ref029) 2007; 81 JD Rabinowitz (ppat.1013569.ref010) 2010; 330 A Medda (ppat.1013569.ref017) 2023; 14 X Li (ppat.1013569.ref002) 2023; 9 N Mizushima (ppat.1013569.ref005) 2010; 140 M Fukuda (ppat.1013569.ref008) 1991; 266 D Jia (ppat.1013569.ref026) 2022; 18 L Jahangiri (ppat.1013569.ref042) 2021; 22 L Zhang (ppat.1013569.ref024) 2023; 19 T Wei (ppat.1013569.ref027) 2006; 87 K Cui (ppat.1013569.ref047) 2004; 24 AE Webb (ppat.1013569.ref014) 2014; 39 Q Liang (ppat.1013569.ref023) 2023; 19 H Mo (ppat.1013569.ref043) 2019; 12 L Galluzzi (ppat.1013569.ref001) 2014; 159 Q Wang (ppat.1013569.ref021) 2022; 18 I Tanida (ppat.1013569.ref007) 2008; 445 B Ding (ppat.1013569.ref037) 2014; 15 RM Usman (ppat.1013569.ref041) 2021; 17 BR Stanton (ppat.1013569.ref032) 1992; 2 H-JR Shin (ppat.1013569.ref003) 2016; 534 N Theodosakis (ppat.1013569.ref018) 2021; 22 |
| References_xml | – volume: 75 start-page: 79 year: 2015 ident: ppat.1013569.ref006 article-title: Autophagic flux determination in vivo and ex vivo publication-title: Methods doi: 10.1016/j.ymeth.2015.01.008 – volume: 266 start-page: 21327 year: 1991 ident: ppat.1013569.ref008 article-title: Lysosomal membrane glycoproteins. Structure, biosynthesis, and intracellular trafficking publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)54636-6 – volume: 15 start-page: 713 issue: 7 year: 2013 ident: ppat.1013569.ref004 article-title: Emerging regulation and functions of autophagy publication-title: Nat Cell Biol doi: 10.1038/ncb2788 – volume: 87 start-page: 429 year: 2006 ident: ppat.1013569.ref027 article-title: Pns12 protein of Rice dwarf virus is essential for formation of viroplasms and nucleation of viral-assembly complexes publication-title: J Gen Virol doi: 10.1099/vir.0.81425-0 – volume: 18 start-page: 745 issue: 4 year: 2022 ident: ppat.1013569.ref021 article-title: Rice black-streaked dwarf virus P10 promotes phosphorylation of GAPDH (glyceraldehyde-3-phosphate dehydrogenase) to induce autophagy in Laodelphax striatellus publication-title: Autophagy doi: 10.1080/15548627.2021.1954773 – volume: 24 start-page: 4476 issue: 10 year: 2004 ident: ppat.1013569.ref047 article-title: The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming publication-title: Mol Cell Biol doi: 10.1128/MCB.24.10.4476-4486.2004 – volume: 132 start-page: 104406 year: 2022 ident: ppat.1013569.ref012 article-title: Relish regulates innate immunity via mediating ATG5 activity in Antheraea pernyi publication-title: Dev Comp Immunol doi: 10.1016/j.dci.2022.104406 – volume: 8 issue: 11 year: 2012 ident: ppat.1013569.ref028 article-title: Tubular structure induced by a plant virus facilitates viral spread in its vector insect publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1003032 – volume: 10 start-page: 2014 issue: 1 year: 2019 ident: ppat.1013569.ref048 article-title: Inhibition of MYC by the SMARCB1 tumor suppressor publication-title: Nat Commun doi: 10.1038/s41467-019-10022-5 – volume: 15 start-page: 564 issue: 5 year: 2014 ident: ppat.1013569.ref037 article-title: Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production publication-title: Cell Host Microbe doi: 10.1016/j.chom.2014.04.004 – volume: 330 start-page: 1344 issue: 6009 year: 2010 ident: ppat.1013569.ref010 article-title: Autophagy and metabolism publication-title: Science doi: 10.1126/science.1193497 – volume: 22 start-page: 151 year: 2021 ident: ppat.1013569.ref018 article-title: The role of MiT/TFE family members in autophagy regulation publication-title: Curr Top Biochem Res – volume: 451 start-page: 1069 issue: 7182 year: 2008 ident: ppat.1013569.ref009 article-title: Autophagy fights disease through cellular self-digestion publication-title: Nature doi: 10.1038/nature06639 – volume: 19 issue: 1 year: 2023 ident: ppat.1013569.ref024 article-title: Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insect publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1011134 – volume: 22 start-page: 5237 issue: 25 year: 2013 ident: ppat.1013569.ref045 article-title: Myc inhibition impairs autophagosome formation publication-title: Hum Mol Genet doi: 10.1093/hmg/ddt381 – volume: 445 start-page: 77 year: 2008 ident: ppat.1013569.ref007 article-title: LC3 and Autophagy publication-title: Methods Mol Biol doi: 10.1007/978-1-59745-157-4_4 – volume: 12 start-page: 1560 issue: 9 year: 2016 ident: ppat.1013569.ref020 article-title: The autophagy pathway participates in resistance to tomato yellow leaf curl virus infection in whiteflies publication-title: Autophagy doi: 10.1080/15548627.2016.1192749 – volume: 39 start-page: 159 issue: 4 year: 2014 ident: ppat.1013569.ref014 article-title: FOXO transcription factors: key regulators of cellular quality control publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2014.02.003 – volume: 17 start-page: 786 issue: 5 year: 2012 ident: ppat.1013569.ref035 article-title: p62 at the interface of autophagy, oxidative stress signaling, and cancer publication-title: Antioxid Redox Signal doi: 10.1089/ars.2011.4394 – volume: 17 start-page: 193 issue: 3 year: 2021 ident: ppat.1013569.ref041 article-title: Role and mechanism of autophagy-regulating factors in tumorigenesis and drug resistance publication-title: Asia Pac J Clin Oncol doi: 10.1111/ajco.13449 – volume: 49 start-page: 1613 issue: 11 year: 2017 ident: ppat.1013569.ref046 article-title: SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters publication-title: Nat Genet doi: 10.1038/ng.3958 – volume: 13 issue: 11 year: 2017 ident: ppat.1013569.ref022 article-title: Autophagy pathway induced by a plant virus facilitates viral spread and transmission by its insect vector publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1006727 – volume: 54 start-page: 99 year: 2016 ident: ppat.1013569.ref039 article-title: Rice Reoviruses in Insect Vectors publication-title: Annu Rev Phytopathol doi: 10.1146/annurev-phyto-080615-095900 – volume: 22 start-page: 102 issue: 1 year: 1999 ident: ppat.1013569.ref033 article-title: c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function publication-title: Nat Genet doi: 10.1038/8811 – volume: 122 start-page: 4621 issue: 12 year: 2012 ident: ppat.1013569.ref044 article-title: ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth publication-title: J Clin Invest doi: 10.1172/JCI62973 – volume: 2 start-page: 71 issue: 1 year: 1992 ident: ppat.1013569.ref032 article-title: The N-myc proto-oncogene: developmental expression and in vivo site-directed mutagenesis publication-title: Brain Pathol doi: 10.1111/j.1750-3639.1991.tb00058.x – volume: 54 issue: 12 year: 2021 ident: ppat.1013569.ref013 article-title: Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5 publication-title: Cell Prolif – volume: 374 start-page: 20180320 issue: 1767 year: 2019 ident: ppat.1013569.ref031 article-title: Interaction of viral pathogen with porin channels on the outer membrane of insect bacterial symbionts mediates their joint transovarial transmission publication-title: Philos Trans R Soc Lond B Biol Sci doi: 10.1098/rstb.2018.0320 – volume: 19 start-page: 616 issue: 2 year: 2023 ident: ppat.1013569.ref023 article-title: A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector publication-title: Autophagy doi: 10.1080/15548627.2022.2091904 – volume: 14 start-page: 719 issue: 11 year: 2023 ident: ppat.1013569.ref017 article-title: c-MYC-dependent transcriptional inhibition of autophagy is implicated in cisplatin sensitivity in HPV-positive head and neck cancer publication-title: Cell Death Dis doi: 10.1038/s41419-023-06248-3 – volume: 80 start-page: 6061 issue: 12 year: 2006 ident: ppat.1013569.ref038 article-title: Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms publication-title: J Virol doi: 10.1128/JVI.02167-05 – volume: 2 start-page: 83 issue: 1 year: 2013 ident: ppat.1013569.ref034 article-title: Divergent roles of autophagy in virus infection publication-title: Cells doi: 10.3390/cells2010083 – volume: 19 start-page: 1100 issue: 4 year: 2023 ident: ppat.1013569.ref025 article-title: GAPDH mediates plant reovirus-induced incomplete autophagy for persistent viral infection in leafhopper vector publication-title: Autophagy doi: 10.1080/15548627.2022.2115830 – volume: 31 start-page: 1251 issue: 12 year: 2023 ident: ppat.1013569.ref019 article-title: Plant reoviruses hijack autophagy in insect vectors publication-title: Trends Microbiol doi: 10.1016/j.tim.2023.06.008 – volume: 15 start-page: 1693 issue: 13 year: 2016 ident: ppat.1013569.ref049 article-title: MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation publication-title: Cell Cycle doi: 10.1080/15384101.2016.1146836 – volume: 100 start-page: 8164 issue: 14 year: 2003 ident: ppat.1013569.ref016 article-title: A global transcriptional regulatory role for c-Myc in Burkitt’s lymphoma cells publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1332764100 – volume: 282 start-page: 24131 issue: 33 year: 2007 ident: ppat.1013569.ref036 article-title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy publication-title: J Biol Chem doi: 10.1074/jbc.M702824200 – volume: 2 start-page: 17025 year: 2017 ident: ppat.1013569.ref030 article-title: Insect symbiotic bacteria harbour viral pathogens for transovarial transmission publication-title: Nat Microbiol doi: 10.1038/nmicrobiol.2017.25 – volume: 534 start-page: 553 issue: 7608 year: 2016 ident: ppat.1013569.ref003 article-title: AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy publication-title: Nature doi: 10.1038/nature18014 – volume: 140 start-page: 313 issue: 3 year: 2010 ident: ppat.1013569.ref005 article-title: Methods in mammalian autophagy research publication-title: Cell doi: 10.1016/j.cell.2010.01.028 – volume: 22 start-page: 8527 issue: 16 year: 2021 ident: ppat.1013569.ref042 article-title: The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers publication-title: Int J Mol Sci doi: 10.3390/ijms22168527 – volume: 18 issue: 5 year: 2022 ident: ppat.1013569.ref026 article-title: A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors publication-title: PLoS Pathog – volume: 81 start-page: 7811 issue: 14 year: 2007 ident: ppat.1013569.ref029 article-title: Entry of Rice dwarf virus into cultured cells of its insect vector involves clathrin-mediated endocytosis publication-title: J Virol doi: 10.1128/JVI.00050-07 – volume: 15 start-page: 640 issue: 2 year: 2024 ident: ppat.1013569.ref015 article-title: MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products publication-title: Aging Dis doi: 10.14336/AD.2023.0520 – volume: 9 start-page: 5134 issue: 18 year: 2019 ident: ppat.1013569.ref040 article-title: C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer publication-title: Theranostics doi: 10.7150/thno.34887 – volume: 159 start-page: 1263 issue: 6 year: 2014 ident: ppat.1013569.ref001 article-title: Metabolic control of autophagy publication-title: Cell doi: 10.1016/j.cell.2014.11.006 – volume: 12 start-page: 7527 year: 2019 ident: ppat.1013569.ref043 article-title: PLK1 contributes to autophagy by regulating MYC stabilization in osteosarcoma cells publication-title: Onco Targets Ther doi: 10.2147/OTT.S210575 – volume: 9 issue: 10 year: 2023 ident: ppat.1013569.ref002 article-title: The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy publication-title: Sci Adv – volume: 19 start-page: 2824 issue: 10 year: 2023 ident: ppat.1013569.ref011 article-title: Transcriptional regulation of autophagy by chromatin remodeling complex and histone variant publication-title: Autophagy doi: 10.1080/15548627.2023.2200352 |
| SSID | ssj0041316 |
| Score | 2.478365 |
| Snippet | Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host’s autophagic machinery. Additionally,... Autophagy plays a crucial role in virus-host interactions, as viral components and particles can be degraded by the host's autophagic machinery. Additionally,... |
| SourceID | doaj proquest pubmed crossref |
| SourceType | Open Website Aggregation Database Index Database |
| StartPage | e1013569 |
| SubjectTerms | Animals Autophagy - physiology Hemiptera - metabolism Hemiptera - virology Insect Vectors - virology Plant Diseases - virology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Reoviridae - pathogenicity Reoviridae - physiology SMARCB1 Protein - genetics SMARCB1 Protein - metabolism |
| Title | Reoviruses hijack the SMARCB1-MYC transcriptional regulation complex to activate autophagy for persistent viral infection in leafhopper vector |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/41066408 https://www.proquest.com/docview/3259855245 https://doaj.org/article/2190a0339613481a9bb3692831924e93 |
| Volume | 21 |
| WOSCitedRecordID | wos001591829000009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Directory of Open Access Journals (DOAJ) customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: DOA dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: M7P dateStart: 20050901 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: BENPR dateStart: 20050901 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection (NC LIVE) customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: 7X7 dateStart: 20050901 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: PIMPY dateStart: 20050901 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: FPL dateStart: 20050101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9sgEEbttpX2UvXd9BFRqVe6jgFjjptoo1baRFa6h-zJAgzdtCvbSpxo90_0N3cAe7WXqpdeLD8QRszAzAfDNwh9zpyR3NmUKFAIAChMEqmVI1Vq0kpyC1YrsOufi-UyX69lcS_Vl48Ji_TAseNOYEQlKqFUgt1h-URJrWkmwSh65GBl4PkEr2cAU3EOhpk5JD31SXGIoFnWH5qjYnLSy-hL26pAH025D3a-Z5QCd__fHc5geObP0NPeY8SnsaXP0QNbv0BPYg7J25fo98o2h812v7M7fLX5qcwvDD4d_r44Xc2mE7K4nOHO26NhdoCqtjH_PDzgEFFub3DXYH_C4QCeJ1Z7TzagftxicGhx6xfUQBXqDvt44Gs8hG_VcIevrXJXTQuF8CGs_79CF_Ozi9lX0idZIIaKpCM5zXSlLVXKWGectbnJrZIAxLRmRiUa8FzobgfOjMmVTJzgLjEAFY10gr5GR3VT27cIc5owpZyT0mrGZaUZdamSAiql0lRshMjQyWUbqTTKsJ8mAILEviy9UMpeKCM09ZK4K-uJsMMLUI-yV4_yX-oxQp8GOZYwcPxuiKpts9-VFIBfznnK-Ai9iQK--xUDoJyxJH_3P5rwHh2nPmlwiAD8gI667d5-RI_NodvstmP0UKxFuOZj9Gh6tixW46DLcJ0X52MfjFrAl-Lborj8A8R5-ao |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Reoviruses+hijack+the+SMARCB1-MYC+transcriptional+regulation+complex+to+activate+autophagy+for+persistent+viral+infection+in+leafhopper+vector&rft.jtitle=PLoS+pathogens&rft.au=Wang%2C+Hui&rft.au=Liu%2C+Runfa&rft.au=Xiao%2C+Guangming&rft.au=Li%2C+Yanan&rft.date=2025-10-01&rft.issn=1553-7374&rft.eissn=1553-7374&rft.volume=21&rft.issue=10&rft.spage=e1013569&rft_id=info:doi/10.1371%2Fjournal.ppat.1013569&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_ppat_1013569 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7374&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7374&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7374&client=summon |