The Role of the Thymus in the Control of Autoimmunity

Self tolerance among T cells is believed to be maintained by two principal mechanisms: clonal deletion for self antigens expressed in the thymus and T cell anergy or T cell indifference for those whose expression is solely extra-thymic. These mechanisms are passive in that they depend on autoreactiv...

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Bibliographic Details
Published in:	Journal of autoimmunity Vol. 9; no. 2; pp. 241 - 246
Main Authors:	Heath, Victoria L., Saoudi, Abdelhadi, Seddon, Benedict P., Moore, Nel C., Fowell, Deborah J., Mason, Don W.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.1996
Subjects:	Animals Autoantigens - immunology Autoimmune Diseases - immunology Autoimmunity - immunology Clonal Deletion Diabetes Mellitus, Experimental - immunology Humans Rats self antigens self tolerance Self Tolerance - immunology T cell anergy T cell indifference T-Lymphocytes - immunology thymus Thymus Gland - immunology T cell anergy self antigens thymus self tolerance T cell indifference
ISSN:	0896-8411, 1095-9157
Online Access:	Get full text
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