Functional, Non-Clonal IgMa-Restricted B Cell Receptor Interactions with the HIV-1 Envelope gp41 Membrane Proximal External Region

The membrane proximal external region (MPER) of HIV-1 gp41 has several features that make it an attractive antibody-based vaccine target, but eliciting an effective gp41 MPER-specific protective antibody response remains elusive. One fundamental issue is whether the failure to make gp41 MPER-specifi...

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Bibliographic Details
Published in:	PloS one Vol. 4; no. 10; p. e7215
Main Authors:	Verkoczy, Laurent, Moody, M. Anthony, Holl, T. Matt, Bouton-Verville, Hilary, Scearce, Richard M., Hutchinson, Jennifer, Alam, S. Munir, Kelsoe, Garnett, Haynes, Barton F.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.10.2009 Public Library of Science (PLoS)
Subjects:	Animals Antibodies Antibody response Antigens Avidity B-Cell Activation Factor Receptor - metabolism B-cell receptor B-Lymphocytes - virology Binding CD79 Antigens - metabolism Cell activation Cell Membrane - metabolism Epitopes - chemistry Female Glycoprotein gp41 HIV HIV Envelope Protein gp41 - metabolism HIV-1 - metabolism Human immunodeficiency virus Immunoglobulin M Immunoglobulins Immunological tolerance Immunology Immunology/Genetics of the Immune System Immunology/Immune Response Immunology/Immunity to Infections Immunology/Immunomodulation Immunology/Leukocyte Signaling and Gene Expression Lymphocyte Activation Lymphocyte receptors Lymphocytes B Mice Mice, Inbred BALB C Mice, Inbred C57BL Monoclonal antibodies Peptides Peritoneum Protein Binding Receptors Signal Transduction Signaling Spleen Spleen - metabolism Vaccines Virology North Carolina United States > US
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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