Organoids in the Clinic: A Systematic Review of Outcomes
Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scien...
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| Vydáno v: | Cells, tissues, organs Ročník 212; číslo 6; s. 499 - 511 |
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| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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Basel, Switzerland
01.12.2023
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| ISSN: | 1422-6405, 1422-6421, 1422-6421 |
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| Abstract | Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed. |
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| AbstractList | Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed.Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed. Research on organoids has undergone significant advances during the last decade. However, outcomes from the use of organoids in clinical trials have not yet been documented. Therefore, there is an urgent need to assess the reporting of clinically relevant outcomes from organoid research in the scientific literature. This article presents a systematic review and appraisal of the published literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, together with a synopsis of recent relevant reviews. Surprisingly, no randomized controlled trials have reported clinical outcomes with any types of organoids. We found very few ongoing and registered studies that may provide clinically relevant results within this decade. Our screening and interpretation of the literature, including review articles, indicate a focus on technical and preclinical aspects of organoid research. This is the first systematic review of clinical trials involving organoids. Few clinical studies are planned or already underway, and, so far, no high-quality evidence relating to the clinical outcomes of organoid research has been published. The many promises of organoid research still need to be translated from bench to bed. |
| Author | Holm, Søren Lewis, Jonathan Zinöcker, Severin Hofmann, Bjørn Kavouras, Panagiotis |
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| Keywords | Evidence Systematic review Organoids Outcomes |
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| PublicationTitle | Cells, tissues, organs |
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| References_xml | – reference: Amorim MM, Souza ASR, Katz L. Planned caesarean section versus planned vaginal birth for severe pre-eclampsia. Cochrane Database Syst Rev. 2017 Oct 23;10(10):Cd009430. – reference: Wensink GE, Elias SG, Mullenders J, Koopman M, Boj SF, Kranenburg OW, . Patient-derived organoids as a predictive biomarker for treatment response in cancer patients. NPJ Precis Oncol. 2021;5(1):30–13. – reference: Lillie EO, Patay B, Diamant J, Issell B, Topol EJ, Schork NJ. The n-of-1 clinical trial: the ultimate strategy for individualizing medicine. Per Med. 2011;8(2):161–73. – reference: Collingridge D. The social control of technology. New York: Martin’s Press; 1982. – reference: Aberle MR, Burkhart RA, Tiriac H, Olde Damink SWM, Dejong CHC, Tuveson DA, . Patient-derived organoid models help define personalized management of gastrointestinal cancer. Br J Surg. 2018 Jan;105(2):e48–60. – reference: Wilson HV. A new method by which sponges may be artificially reared. Science. 1907 Jun 7;25(649):912–5. – reference: Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. – reference: Shrestha J, Razavi Bazaz S, Aboulkheyr Es H, Yaghobian Azari D, Thierry B, Ebrahimi Warkiani M, . Lung-on-a-chip: the future of respiratory disease models and pharmacological studies. Crit Rev Biotechnol. 2020 Mar;40(2):213–30. – reference: Lancaster MA, Knoblich JA. Organogenesis in a dish: modeling development and disease using organoid technologies. Science. 2014;345(6194):1247125. – reference: Li ML, Aggeler J, Farson DA, Hatier C, Hassell J, Bissell MJ. Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells. Proc Natl Acad Sci U S A. 1987 Jan;84(1):136–40. – reference: Sun J. The clinical efficacy of drug sensitive neoadjuvant chemotherapy based on organoid versus traditional neoadjuvant chemotherapy in advanced rectal cancer. ClinicalTrials.gov. Shanghai Minimally Invasive Surgery Center; 2022. – reference: Veritas Health Innovation. Covidence systematic review software. Melbourne, Australia: Veritas Health Innovation; 2009. – reference: Saini A. Cystic fibrosis patients benefit from mini guts. Cell Stem Cell. 2016;19(4):425–7. – reference: Chen HI, Wolf JA, Blue R, Song MM, Moreno JD, Ming GL, . Transplantation of human brain organoids: revisiting the science and ethics of brain chimeras. Cell Stem Cell. 2019b;25(4):462–72. – reference: Fenn J, Raskino M. Mastering the hype cycle: how to choose the right innovation at the right time. Harvard Business Press; 2008. – reference: Higgins J, Savović J, Page M, Elbers R, Sterne J. Chapter 8: assessing risk of bias in a randomized trial. In: Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, , editors. Cochrane handbook for systematic reviews of interventions version 6-3 cochrane; 2022. – reference: Abdollahi S. Extracellular vesicles from organoids and 3D culture systems. Biotechnol Bioeng. 2021 Mar;118(3):1029–49. – reference: Schüneman H, Brożek J, Guyatt G, Oxman A, editors. GRADE handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. GRADE Working Group; 2013. – reference: Gaskell H, Moore RA, Derry S, Stannard C. Oxycodone for pain in fibromyalgia in adults. Cochrane Database Syst Rev. 2016 Sep 1;9(9):Cd012329. – reference: Genus A, Stirling A. Collingridge and the dilemma of control: towards responsible and accountable innovation. Res Policy. 2018;47(1):61–9. – reference: Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K. Tumor-derived spheroids: relevance to cancer stem cells and clinical applications. Cancer Sci. 2017 Mar;108(3):283–9. – reference: Dekkers JF, Berkers G, Kruisselbrink E, Vonk A, De Jonge HR, Janssens HM, . Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Sci Transl Med. 2016;8(344):344ra84. – reference: Mead BE, Karp JM. All models are wrong, but some organoids may be useful. Genome Biol. 2019 Mar 27;20(1):66. – reference: Xinaris C. Organoids for replacement therapy: expectations, limitations and reality. Curr Opin Organ Transplant. 2019;24(5):555–61. – reference: Xu M, Lee EM, Wen Z, Cheng Y, Huang W-K, Qian X, . Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016;22(10):1101–7. – reference: Schneemann SA, Boers SN, van Delden JJM, Nieuwenhuis EES, Fuchs SA, Bredenoord AL. Ethical challenges for pediatric liver organoid transplantation. 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| Title | Organoids in the Clinic: A Systematic Review of Outcomes |
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