Structure-function coupling in highly sampled individual brains

Structural connectivity (SC) between distant regions of the brain support synchronized function known as functional connectivity (FC) and give rise to the large-scale brain networks that enable cognition and behavior. Understanding how SC enables FC is important to understand how injuries to SC may...

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Published in:Cerebral cortex (New York, N.Y. 1991) Vol. 34; no. 9
Main Authors: Rajesh, Aishwarya, Seider, Nicole A, Newbold, Dillan J, Adeyemo, Babatunde, Marek, Scott, Greene, Deanna J, Snyder, Abraham Z, Shimony, Joshua S, Laumann, Timothy O, Dosenbach, Nico U F, Gordon, Evan M
Format: Journal Article
Language:English
Published: United States 03.09.2024
Subjects:
Adult
Brain - diagnostic imaging
Brain - physiology
Brain Mapping - methods
Diffusion Magnetic Resonance Imaging
Female
Humans
Magnetic Resonance Imaging - methods
Male
Neural Pathways - diagnostic imaging
Neural Pathways - physiology
Rest - physiology
White Matter - diagnostic imaging
White Matter - physiology
Young Adult
functional imaging
individual
diffusion imaging
dense sampling
structure–function coupling
ISSN:1460-2199, 1460-2199
Online Access:Get more information
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Summary:Structural connectivity (SC) between distant regions of the brain support synchronized function known as functional connectivity (FC) and give rise to the large-scale brain networks that enable cognition and behavior. Understanding how SC enables FC is important to understand how injuries to SC may alter brain function and cognition. Previous work evaluating whole-brain SC-FC relationships showed that SC explained FC well in unimodal visual and motor areas, but only weakly in association areas, suggesting a unimodal-heteromodal gradient organization of SC-FC coupling. However, this work was conducted in group-averaged SC/FC data. Thus, it could not account for inter-individual variability in the locations of cortical areas and white matter tracts. We evaluated the correspondence of SC and FC within three highly sampled healthy participants. For each participant, we collected 78 min of diffusion-weighted MRI for SC and 360 min of resting state fMRI for FC. We found that FC was best explained by SC in visual and motor systems, as well as in anterior and posterior cingulate regions. A unimodal-to-heteromodal gradient could not fully explain SC-FC coupling. We conclude that the SC-FC coupling of the anterior-posterior cingulate circuit is more similar to unimodal areas than to heteromodal areas.
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ISSN:1460-2199
1460-2199
DOI:10.1093/cercor/bhae361