DNAmFitAge: biological age indicator incorporating physical fitness

Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction. We develop blood-ba...

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Vydané v:Aging (Albany, NY.) Ročník 15; číslo 10; s. 3904
Hlavní autori: McGreevy, Kristen M, Radak, Zsolt, Torma, Ferenc, Jokai, Matyas, Lu, Ake T, Belsky, Daniel W, Binder, Alexandra, Marioni, Riccardo E, Ferrucci, Luigi, Pośpiech, Ewelina, Branicki, Wojciech, Ossowski, Andrzej, Sitek, Aneta, Spólnicka, Magdalena, Raffield, Laura M, Reiner, Alex P, Cox, Simon, Kobor, Michael, Corcoran, David L, Horvath, Steve
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 22.02.2023
Predmet:
Aging - genetics
Biomarkers
DNA Methylation
Environmental Biomarkers
Epigenesis, Genetic
Female
Hand Strength
Humans
Male
Physical Fitness
DNA methylation
aging
biological age
physical fitness
epigenetics
ISSN:1945-4589, 1945-4589
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Shrnutí:Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction. We develop blood-based DNAm biomarkers for fitness parameters gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max) which have modest correlation with fitness parameters in five large-scale validation datasets (average r between 0.16-0.48). We then use these DNAm fitness parameter biomarkers with DNAmGrimAge, a DNAm mortality risk estimate, to construct DNAmFitAge, a new biological age indicator that incorporates physical fitness. DNAmFitAge is associated with low-intermediate physical activity levels across validation datasets ( = 6.4E-13), and younger/fitter DNAmFitAge corresponds to stronger DNAm fitness parameters in both males and females. DNAmFitAge is lower ( = 0.046) and DNAmVO2max is higher ( = 0.023) in male body builders compared to controls. Physically fit people have a younger DNAmFitAge and experience better age-related outcomes: lower mortality risk ( = 7.2E-51), coronary heart disease risk ( = 2.6E-8), and increased disease-free status ( = 1.1E-7). These new DNAm biomarkers provide researchers a new method to incorporate physical fitness into epigenetic clocks.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1945-4589
1945-4589
DOI:10.18632/aging.204538