Activated protein C inhibits lipopolysaccharide‐mediated acetylation and secretion of high‐mobility group box 1 in endothelial cells

Essentials APC elicits cytoprotective responses in endothelial cells via EPCR‐dependent cleavage of PAR1. APC inhibits LPS‐mediated translocation and extracellular secretion of HMGB1 in endothelial cells. Signaling activity of APC inhibits LPS‐mediated acetylation of HMGB1 by epigenetic mechanisms....

Full description

Saved in:

Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 17; no. 5; pp. 803 - 817
Main Authors:	Cai, Xiaofeng, Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Rezaie, Alireza R.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01.05.2019
Subjects:	Acetylation Activated protein C activated protein C Cytoplasm Endothelial cells endothelial protein C receptor HMGB1 HMGB1 protein Immunofluorescence Lipopolysaccharides Localization Lysates Membrane proteins Mobility protease‐activated receptor 1 Proteins Rodents Thrombin acetylation endothelial protein C receptor protease-activated receptor 1 HMGB1 activated protein C
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!