Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells

•Chronic GLP-1R stimulation promotes β-cell metabolic reprogramming.•IGF-1R and IR are important for β-cell development, function and proliferation.•GLP-1 enhanced metabolic phenotype is independent of IR and IGF-1R autocrine loops.•Enhanced metabolism can contribute to GLP-1 pro-survival abilities....

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Bibliographic Details
Published in:	Peptides (New York, N.Y. : 1980) Vol. 100; pp. 140 - 149
Main Authors:	Rowlands, Jordan, Cruzat, Vinicius, Carlessi, Rodrigo, Newsholme, Philip
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2018
Subjects:	Animals Autocrine Communication - drug effects Bioenergetics BRIN-BD11 beta cells Diabetes Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Energy Metabolism - drug effects Exenatide - administration & dosage Exendin-4 GLP-1 Glucagon-Like Peptide-1 Receptor - genetics Glucose - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Insulin Insulin - genetics Insulin-Secreting Cells - drug effects Metabolism Rats Receptor, IGF Type 1 - genetics Receptor, Insulin - genetics TOR Serine-Threonine Kinases - genetics GLP-1 Bioenergetics BRIN-BD11 beta cells Diabetes Metabolism Insulin Exendin-4
ISSN:	0196-9781, 1873-5169, 1873-5169
Online Access:	Get full text
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