Tetrazine metallation boosts rate and regioselectivity of inverse electron demand Diels-Alder (iEDDA) addition of dienophiles

Reported herein is the coordination of rhenium complexes to tetrazine ligand in [ReCl(CO)3(TzPy)] [1] (TzPy = 3-(2-pyridyl)-1,2,4,5-tetrazine) and the rates of addition of different dienophiles to the tetrazine. Tetrazine coordiation lowers the ΔS‡ contribution to ΔG‡ for iEDDA addition.Reported her...

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Bibliographic Details

Published in:	Chemical communications (Cambridge, England) Vol. 56; no. 80; p. 12033
Main Authors:	Schnierle, Marc, Blickle, Svenja, Filippou, Vasileios, Ringenberg, Mark R
Format:	Journal Article
Language:	English
Published:	14.10.2020
ISSN:	1364-548X, 1364-548X
Online Access:	Get more information
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