MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer

In microorganisms, evolutionarily conserved mechanisms facilitate adaptation to harsh conditions through stress-induced mutagenesis (SIM). Analogous processes may underpin progression and therapeutic failure in human cancer. We describe SIM in multiple in vitro and in vivo models of human cancers un...

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Vydané v:	Science (American Association for the Advancement of Science) Ročník 368; číslo 6495; s. 1127
Hlavní autori:	Cipponi, Arcadi, Goode, David L, Bedo, Justin, McCabe, Mark J, Pajic, Marina, Croucher, David R, Rajal, Alvaro Gonzalez, Junankar, Simon R, Saunders, Darren N, Lobachevsky, Pavel, Papenfuss, Anthony T, Nessem, Danielle, Nobis, Max, Warren, Sean C, Timpson, Paul, Cowley, Mark, Vargas, Ana C, Qiu, Min R, Generali, Daniele G, Keerthikumar, Shivakumar, Nguyen, Uyen, Corcoran, Niall M, Long, Georgina V, Blay, Jean-Yves, Thomas, David M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	05.06.2020
ISSN:	1095-9203, 1095-9203
On-line prístup:	Zistit podrobnosti o prístupe
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