Cosmetic benefits of astaxanthin on humans subjects

Two human clinical studies were performed. One was an open-label non-controlled study involving 30 healthy female subjects for 8 weeks. Significant improvements were observed by combining 6 mg per day oral supplementation and 2 ml (78.9 μM solution) per day topical application of astaxanthin. Astaxa...

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Veröffentlicht in:Acta biochimica Polonica Jg. 59; H. 1; S. 43
Hauptverfasser: Tominaga, Kumi, Hongo, Nobuko, Karato, Mariko, Yamashita, Eiji
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland 01.01.2012
Schlagworte:
Adult
Cosmetics - pharmacology
Double-Blind Method
Female
Humans
Male
Middle Aged
Skin - drug effects
Skin Aging - drug effects
Treatment Outcome
Xanthophylls - pharmacology
Young Adult
ISSN:0001-527X, 1734-154X
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Zusammenfassung:Two human clinical studies were performed. One was an open-label non-controlled study involving 30 healthy female subjects for 8 weeks. Significant improvements were observed by combining 6 mg per day oral supplementation and 2 ml (78.9 μM solution) per day topical application of astaxanthin. Astaxanthin derived from the microalgae, Haematococcus pluvialis showed improvements in skin wrinkle (crow's feet at week-8), age spot size (cheek at week-8), elasticity (crow's feet at week-8), skin texture (cheek at week-4), moisture content of corneocyte layer (cheek in 10 dry skin subjects at week-8) and corneocyte condition (cheek at week-8). It may suggest that astaxanthin derived from H. pluvialis can improve skin condition in all layers such as corneocyte layer, epidermis, basal layer and dermis by combining oral supplementation and topical treatment. Another was a randomized double-blind placebo controlled study involving 36 healthy male subjects for 6 weeks. Crow's feet wrinkle and elasticity; and transepidermal water loss (TEWL) were improved after 6 mg of astaxanthin (the same as former study) daily supplementation. Moisture content and sebum oil level at the cheek zone showed strong tendencies for improvement. These results suggest that astaxanthin derived from Haematococcus pluvialis may improve the skin condition in not only in women but also in men.
ISSN:0001-527X
1734-154X
DOI:10.18388/abp.2012_2168