Chlorpyrifos and dimethoate exposure impairs female fertility by deregulating WNT signaling pathway & uterine receptivity

The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pes...

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Bibliographic Details
Published in:	Reproductive toxicology (Elmsford, N.Y.) Vol. 130; p. 108735
Main Authors:	Jan, Jasmeena, Bashir, Showkeen Muzamil, Sheikh, Wajid Mohammad, Bhat, Owais Mohmad, Rafeeqi, Towseef Amin, Shah, Showkat Ahmad, Dar, Abid Hamid, Zargar, Mohammad Afzal, Wani, Nissar Ahmad
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2024
Subjects:	Animals Biochemical parameters Chlorpyrifos Chlorpyrifos - toxicity Dimethoate Dimethoate - toxicity Female Fertility - drug effects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism HOXA genes Inflammation Insecticides - toxicity NF-kappa B - metabolism Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Uterine health Uterus - drug effects Uterus - metabolism WNT genes Wnt Signaling Pathway - drug effects Chlorpyrifos Oxidative stress Uterine health Biochemical parameters WNT genes HOXA genes Inflammation Dimethoate
ISSN:	0890-6238, 1873-1708, 1873-1708
Online Access:	Get full text
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