Chlorpyrifos and dimethoate exposure impairs female fertility by deregulating WNT signaling pathway & uterine receptivity

The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pes...

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Published in:	Reproductive toxicology (Elmsford, N.Y.) Vol. 130; p. 108735
Main Authors:	Jan, Jasmeena, Bashir, Showkeen Muzamil, Sheikh, Wajid Mohammad, Bhat, Owais Mohmad, Rafeeqi, Towseef Amin, Shah, Showkat Ahmad, Dar, Abid Hamid, Zargar, Mohammad Afzal, Wani, Nissar Ahmad
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2024
Subjects:	Animals Biochemical parameters Chlorpyrifos Chlorpyrifos - toxicity Dimethoate Dimethoate - toxicity Female Fertility - drug effects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism HOXA genes Inflammation Insecticides - toxicity NF-kappa B - metabolism Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Uterine health Uterus - drug effects Uterus - metabolism WNT genes Wnt Signaling Pathway - drug effects Chlorpyrifos Oxidative stress Uterine health Biochemical parameters WNT genes HOXA genes Inflammation Dimethoate
ISSN:	0890-6238, 1873-1708, 1873-1708
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Abstract	The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pesticides caused degenerative changes in uterine tissue. This study demonstrates that pesticides induce inflammatory responses and oxidative stress in rats, by NF-κB activation and altering antioxidant enzyme levels. Besides, CPF and DM exposure disrupted gene expression of HOXA10, HOXA11, and WNT and reduced activation of β-catenin in the uterus, which is crucial for implantation and reproductive function. These findings suggest that pesticide exposure may impair reproductive health and fertility in females, highlighting potential implications for human health. [Display omitted] •CPM and DM exposure induce severe structural damage in the uterus of female rats.•CPM and DM exposure impairs biochemical and metabolic parameters of female rats.•Pesticide exposure undermines the oxidative defense mechanism.•Dysregulation of WNT signaling and genes related to uterine development & receptivity.•These alterations suggested compromised uterine function, thereby fertility.
AbstractList	The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pesticides caused degenerative changes in uterine tissue. This study demonstrates that pesticides induce inflammatory responses and oxidative stress in rats, by NF-κB activation and altering antioxidant enzyme levels. Besides, CPF and DM exposure disrupted gene expression of HOXA10, HOXA11, and WNT and reduced activation of β-catenin in the uterus, which is crucial for implantation and reproductive function. These findings suggest that pesticide exposure may impair reproductive health and fertility in females, highlighting potential implications for human health. The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pesticides caused degenerative changes in uterine tissue. This study demonstrates that pesticides induce inflammatory responses and oxidative stress in rats, by NF-κB activation and altering antioxidant enzyme levels. Besides, CPF and DM exposure disrupted gene expression of HOXA10, HOXA11, and WNT and reduced activation of β-catenin in the uterus, which is crucial for implantation and reproductive function. These findings suggest that pesticide exposure may impair reproductive health and fertility in females, highlighting potential implications for human health.The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pesticides caused degenerative changes in uterine tissue. This study demonstrates that pesticides induce inflammatory responses and oxidative stress in rats, by NF-κB activation and altering antioxidant enzyme levels. Besides, CPF and DM exposure disrupted gene expression of HOXA10, HOXA11, and WNT and reduced activation of β-catenin in the uterus, which is crucial for implantation and reproductive function. These findings suggest that pesticide exposure may impair reproductive health and fertility in females, highlighting potential implications for human health. The study assessed histological, biochemical, oxidative stress, and molecular parameters to evaluate the consequences of Chlorpyrifos and Dimethoate exposure on uterine health in female rats. Despite showing no obvious signs of toxicity apart from minor clinical symptoms in DM-exposed rats, both pesticides caused degenerative changes in uterine tissue. This study demonstrates that pesticides induce inflammatory responses and oxidative stress in rats, by NF-κB activation and altering antioxidant enzyme levels. Besides, CPF and DM exposure disrupted gene expression of HOXA10, HOXA11, and WNT and reduced activation of β-catenin in the uterus, which is crucial for implantation and reproductive function. These findings suggest that pesticide exposure may impair reproductive health and fertility in females, highlighting potential implications for human health. [Display omitted] •CPM and DM exposure induce severe structural damage in the uterus of female rats.•CPM and DM exposure impairs biochemical and metabolic parameters of female rats.•Pesticide exposure undermines the oxidative defense mechanism.•Dysregulation of WNT signaling and genes related to uterine development & receptivity.•These alterations suggested compromised uterine function, thereby fertility.
ArticleNumber	108735
Author	Wani, Nissar Ahmad Bhat, Owais Mohmad Bashir, Showkeen Muzamil Sheikh, Wajid Mohammad Shah, Showkat Ahmad Rafeeqi, Towseef Amin Zargar, Mohammad Afzal Jan, Jasmeena Dar, Abid Hamid
Author_xml	– sequence: 1 givenname: Jasmeena surname: Jan fullname: Jan, Jasmeena organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India – sequence: 2 givenname: Showkeen Muzamil surname: Bashir fullname: Bashir, Showkeen Muzamil organization: Biochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, Jammu & Kashmir 190006, India – sequence: 3 givenname: Wajid Mohammad surname: Sheikh fullname: Sheikh, Wajid Mohammad organization: Biochemistry & Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, Jammu & Kashmir 190006, India – sequence: 4 givenname: Owais Mohmad surname: Bhat fullname: Bhat, Owais Mohmad organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India – sequence: 5 givenname: Towseef Amin surname: Rafeeqi fullname: Rafeeqi, Towseef Amin organization: Biochemistry, Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir, India – sequence: 6 givenname: Showkat Ahmad surname: Shah fullname: Shah, Showkat Ahmad organization: Division of Veterinary Pathology, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology, Srinagar, Jammu & Kashmir, India – sequence: 7 givenname: Abid Hamid surname: Dar fullname: Dar, Abid Hamid organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India – sequence: 8 givenname: Mohammad Afzal surname: Zargar fullname: Zargar, Mohammad Afzal organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India – sequence: 9 givenname: Nissar Ahmad surname: Wani fullname: Wani, Nissar Ahmad email: waninh@yahoo.co.in, waninh@cukashmir.ac.in organization: Department of Biotechnology, School of Life Sciences, Central University of Kashmir, Ganderbal, India
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Keywords	Chlorpyrifos Oxidative stress Uterine health Biochemical parameters WNT genes HOXA genes Inflammation Dimethoate
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SubjectTerms	Animals Biochemical parameters Chlorpyrifos Chlorpyrifos - toxicity Dimethoate Dimethoate - toxicity Female Fertility - drug effects Homeodomain Proteins - genetics Homeodomain Proteins - metabolism HOXA genes Inflammation Insecticides - toxicity NF-kappa B - metabolism Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Uterine health Uterus - drug effects Uterus - metabolism WNT genes Wnt Signaling Pathway - drug effects
Title	Chlorpyrifos and dimethoate exposure impairs female fertility by deregulating WNT signaling pathway & uterine receptivity
URI	https://dx.doi.org/10.1016/j.reprotox.2024.108735 https://www.ncbi.nlm.nih.gov/pubmed/39419344 https://www.proquest.com/docview/3117992861
Volume	130
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