Dementia and epilepsy without traumatic brain injury among subjects middle-aged females: a population-based case-control study

Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI. We aimed to investigate the relationship between dementia and ep...

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Bibliographic Details
Published in:Journal of Alzheimer's disease Vol. 103; no. 4; p. 1171
Main Authors: Chu, Shu-Fen, Ni, Cheng-Hua, Liao, Kuo-Hsing, Wen, Ya-Ting
Format: Journal Article
Language:English
Published: United States 01.02.2025
Subjects:
Adult
Aged
Brain Injuries, Traumatic - epidemiology
Case-Control Studies
Cohort Studies
Dementia - epidemiology
Epilepsy - epidemiology
Female
Humans
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Sex Factors
Alzheimer's disease, dementia, epilepsy, population-based study, traumatic brain injury
ISSN:1875-8908, 1875-8908
Online Access:Get more information
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Summary:Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI. We aimed to investigate the relationship between dementia and epilepsy in a population-based study of patients without history of TBI. This study included a random sample of 30,715 patients with no history of TBI, including 6143 with epilepsy as the study cohort and 24,572 without epilepsy as the comparison cohort. Stratified Cox proportional hazard regression was used to calculate the adjusted hazard ratio (HR), with 95% confidence interval, for the risk of developing dementia in the two cohorts. Patients with epilepsy but no history of TBI had increased risk of dementia (adjusted HR = 1.84). For patients aged 55-64 years, the adjusted HR for dementia was 4.5-fold higher among females in the study cohort than among males. Additionally, this study revealed that risk of dementia among above 75-year population lowest than other age subgroups (adjusted HR = 1.45). The study demonstrated an association between dementia and epilepsy in the patients who had no history of TBI. The effect was pronounced in patients aged 55-64 years, especially in the female population, suggesting that epilepsy needs to be more intensively prevented and controlled in this age group.
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ISSN:1875-8908
1875-8908
DOI:10.1177/13872877241312985