Dementia and epilepsy without traumatic brain injury among subjects middle-aged females: a population-based case-control study
Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI. We aimed to investigate the relationship between dementia and ep...
Uloženo v:
| Vydáno v: | Journal of Alzheimer's disease Ročník 103; číslo 4; s. 1171 |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.02.2025
|
| Témata: | |
| ISSN: | 1875-8908, 1875-8908 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI.
We aimed to investigate the relationship between dementia and epilepsy in a population-based study of patients without history of TBI.
This study included a random sample of 30,715 patients with no history of TBI, including 6143 with epilepsy as the study cohort and 24,572 without epilepsy as the comparison cohort. Stratified Cox proportional hazard regression was used to calculate the adjusted hazard ratio (HR), with 95% confidence interval, for the risk of developing dementia in the two cohorts.
Patients with epilepsy but no history of TBI had increased risk of dementia (adjusted HR = 1.84). For patients aged 55-64 years, the adjusted HR for dementia was 4.5-fold higher among females in the study cohort than among males. Additionally, this study revealed that risk of dementia among above 75-year population lowest than other age subgroups (adjusted HR = 1.45).
The study demonstrated an association between dementia and epilepsy in the patients who had no history of TBI. The effect was pronounced in patients aged 55-64 years, especially in the female population, suggesting that epilepsy needs to be more intensively prevented and controlled in this age group. |
|---|---|
| AbstractList | Background: Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI. Objective: We aimed to investigate the relationship between dementia and epilepsy in a population-based study of patients without history of TBI. Methods: This study included a random sample of 30,715 patients with no history of TBI, including 6143 with epilepsy as the study cohort and 24,572 without epilepsy as the comparison cohort. Stratified Cox proportional hazard regression was used to calculate the adjusted hazard ratio (HR), with 95% confidence interval, for the risk of developing dementia in the two cohorts. Results: Patients with epilepsy but no history of TBI had increased risk of dementia (adjusted HR = 1.84). For patients aged 55-64 years, the adjusted HR for dementia was 4.5-fold higher among females in the study cohort than among males. Additionally, this study revealed that risk of dementia among above 75-year population lowest than other age subgroups (adjusted HR = 1.45). Conclusions: The study demonstrated an association between dementia and epilepsy in the patients who had no history of TBI. The effect was pronounced in patients aged 55-64 years, especially in the female population, suggesting that epilepsy needs to be more intensively prevented and controlled in this age group.Background: Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI. Objective: We aimed to investigate the relationship between dementia and epilepsy in a population-based study of patients without history of TBI. Methods: This study included a random sample of 30,715 patients with no history of TBI, including 6143 with epilepsy as the study cohort and 24,572 without epilepsy as the comparison cohort. Stratified Cox proportional hazard regression was used to calculate the adjusted hazard ratio (HR), with 95% confidence interval, for the risk of developing dementia in the two cohorts. Results: Patients with epilepsy but no history of TBI had increased risk of dementia (adjusted HR = 1.84). For patients aged 55-64 years, the adjusted HR for dementia was 4.5-fold higher among females in the study cohort than among males. Additionally, this study revealed that risk of dementia among above 75-year population lowest than other age subgroups (adjusted HR = 1.45). Conclusions: The study demonstrated an association between dementia and epilepsy in the patients who had no history of TBI. The effect was pronounced in patients aged 55-64 years, especially in the female population, suggesting that epilepsy needs to be more intensively prevented and controlled in this age group. Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge gaps with respect to the perspective of dementia and epilepsy without TBI. We aimed to investigate the relationship between dementia and epilepsy in a population-based study of patients without history of TBI. This study included a random sample of 30,715 patients with no history of TBI, including 6143 with epilepsy as the study cohort and 24,572 without epilepsy as the comparison cohort. Stratified Cox proportional hazard regression was used to calculate the adjusted hazard ratio (HR), with 95% confidence interval, for the risk of developing dementia in the two cohorts. Patients with epilepsy but no history of TBI had increased risk of dementia (adjusted HR = 1.84). For patients aged 55-64 years, the adjusted HR for dementia was 4.5-fold higher among females in the study cohort than among males. Additionally, this study revealed that risk of dementia among above 75-year population lowest than other age subgroups (adjusted HR = 1.45). The study demonstrated an association between dementia and epilepsy in the patients who had no history of TBI. The effect was pronounced in patients aged 55-64 years, especially in the female population, suggesting that epilepsy needs to be more intensively prevented and controlled in this age group. |
| Author | Liao, Kuo-Hsing Wen, Ya-Ting Ni, Cheng-Hua Chu, Shu-Fen |
| Author_xml | – sequence: 1 givenname: Shu-Fen orcidid: 0009-0002-3685-8765 surname: Chu fullname: Chu, Shu-Fen organization: College of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, Shanghai, China – sequence: 2 givenname: Cheng-Hua surname: Ni fullname: Ni, Cheng-Hua organization: Department of Nursing, Wan Fang Hospital, Taipei Medical University, Taipei – sequence: 3 givenname: Kuo-Hsing orcidid: 0000-0002-1047-9743 surname: Liao fullname: Liao, Kuo-Hsing organization: Division of Neurosurgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei – sequence: 4 givenname: Ya-Ting orcidid: 0000-0001-9152-7286 surname: Wen fullname: Wen, Ya-Ting organization: Taipei Neuroscience Institute, Taipei Medical University, Taipei |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39846180$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUDtPwzAYtFARpcAPYEEeWQJ2HMcOGypPCYkF5upz_KW4SuwQ20Jd-O1UokgsdyfdY7gFmfngkZBzzq44V-qaC61KrVRZccHLRssDcsy1koVumJ7903OyiHHDGBOsUUdkLhpd1VyzY_J9hwP65ICCtxRH1-MYt_TLpY-QE00T5AGSa6mZwHnq_CZPWwpD8Gsas9lgmyIdnLU9FrBGSzscoMd4Q4GOYcz9rhx8YSDuvHaHRRt8mkJPY8p2e0oOO-gjnu35hLw_3L8tn4qX18fn5e1L0Ypap0JaLUs0nEEtbAedYazRTIi6q7FrRVVWYKpGcsEsojUa20Y1qmaV5EZyKMsTcvm7O07hM2NMq8HFFvsePIYcV4JLrWpZab6LXuyj2QxoV-PkBpi2q7_Pyh86nnKZ |
| CitedBy_id | crossref_primary_10_1016_j_cpsurg_2025_101797 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1177/13872877241312985 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 1875-8908 |
| ExternalDocumentID | 39846180 |
| Genre | Journal Article |
| GroupedDBID | --- 0R~ 0VX 29J 36B 4.4 53G 5GY AAEJI AAFNC AAFWJ AAGLT AAPII AAQXI AAWTL ABDBF ABIVO ABJNI ABJZC ABUBZ ABUJY ACGFS ACPQW ACPRK ACUHS ADEBD ADZMO AEJQA AELRD AENEX AFRAH AFRHK AFYTF AGIAB AHDMH AIRSE AJGYC AJNRN ALIRC ALMA_UNASSIGNED_HOLDINGS APPIZ ARTOV CAG CGR COF CUY CVF DU5 EAD EAP EBS ECM EIF EJD EMB EMK EMOBN ESX F5P H13 HZ~ IL9 IOS J8X MET MIO MV1 NGNOM NPM O9- P2P Q1R SAUOL SCNPE SFC SV3 TUS VUG 7X8 ACARO |
| ID | FETCH-LOGICAL-c368t-5d852eb10a63dfafb00980336f6efc3424ab495130deedb8ec979760451b51a22 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001436287700011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1875-8908 |
| IngestDate | Sun Nov 09 13:51:13 EST 2025 Mon Jul 21 05:43:14 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Alzheimer's disease, dementia, epilepsy, population-based study, traumatic brain injury |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c368t-5d852eb10a63dfafb00980336f6efc3424ab495130deedb8ec979760451b51a22 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-9152-7286 0009-0002-3685-8765 0000-0002-1047-9743 |
| PMID | 39846180 |
| PQID | 3158765481 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3158765481 pubmed_primary_39846180 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-Feb 20250201 |
| PublicationDateYYYYMMDD | 2025-02-01 |
| PublicationDate_xml | – month: 02 year: 2025 text: 2025-Feb |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of Alzheimer's disease |
| PublicationTitleAlternate | J Alzheimers Dis |
| PublicationYear | 2025 |
| SSID | ssj0003097 |
| Score | 2.4429414 |
| Snippet | Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant knowledge... Background: Although the association between dementia such as Alzheimer's disease and traumatic brain injury (TBI) is well established, there are significant... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1171 |
| SubjectTerms | Adult Aged Brain Injuries, Traumatic - epidemiology Case-Control Studies Cohort Studies Dementia - epidemiology Epilepsy - epidemiology Female Humans Male Middle Aged Proportional Hazards Models Risk Factors Sex Factors |
| Title | Dementia and epilepsy without traumatic brain injury among subjects middle-aged females: a population-based case-control study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/39846180 https://www.proquest.com/docview/3158765481 |
| Volume | 103 |
| WOSCitedRecordID | wos001436287700011&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3LSsQwFA3quHDjA1_jiwhug23SR-pGRB3cOMxCYXYlTxhh2jptBTd-uzdpx1kJgpvsAiG5uefk3nAOQlc8CyILcUEktSmJ0iAiXBhFYm0AHqQwiRDebCIdj_l0mk36glvdf6tc5kSfqHWpXI38moUxXFzg1-Ft9U6ca5TrrvYWGutowIDKuKhOpyu1cBZ05irAyQksivddTSe4FDKewmMhdW0lgDwe_84wPdKMdv67xl203XNMfNcFxR5aM8U--nrwhcCZwKLQ2FSQDar6E7s6bNk2uFmI1qu3YulMI_CseIPdxt6LCNetdOWaGs99OYNADtLYmjmAS32DBa5-XMCIQ0WNFYyk_wWPvYLtAXodPb7cP5HefIEolvAGDovHFBJ5IBKmrbDSKY8GjCU2MVaxiEZCwuMKIFADzEpuVJYCtXFyNTIOBaWHaKMoC3OMcECNpQnVWnMdSeU05m0ME1iUiSRQaogul9uZQ3C7joUoTNnW-WpDh-ioO5O86lQ4cpYBdQp5cPKH2adoizrfXv_b-gwNLFxtc4421UczqxcXPmpgHE-evwHOXM8L |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dementia+and+epilepsy+without+traumatic+brain+injury+among+subjects+middle-aged+females%3A+a+population-based+case-control+study&rft.jtitle=Journal+of+Alzheimer%27s+disease&rft.au=Chu%2C+Shu-Fen&rft.au=Ni%2C+Cheng-Hua&rft.au=Liao%2C+Kuo-Hsing&rft.au=Wen%2C+Ya-Ting&rft.date=2025-02-01&rft.eissn=1875-8908&rft.volume=103&rft.issue=4&rft.spage=1171&rft_id=info:doi/10.1177%2F13872877241312985&rft_id=info%3Apmid%2F39846180&rft_id=info%3Apmid%2F39846180&rft.externalDocID=39846180 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1875-8908&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1875-8908&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1875-8908&client=summon |