Interactive visual exploration of metabolite ratios in MR spectroscopy studies

•SpectraMosaic allows for interactive visual analysis of MRS single voxel ratios.•With our tool, experts may analyze complete, complex metabolite signatures.•A tiered visual encoding system provides a prioritized, layered analysis approach.•The first analysis level compares user-defined metabolite g...

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Bibliographic Details
Published in:Computers & graphics Vol. 92; pp. 1 - 12
Main Authors: Garrison, Laura, Vašíček, Jakub, Craven, Alexander R., Grüner, Renate, Smit, Noeska N., Bruckner, Stefan
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 01.11.2020
Elsevier Science Ltd
Subjects:
Applications to biology and medical sciences
Biomedical imaging and signal processing
Computing methodologies and applications
Data analysis
decision support
etc.
Information systems (hypertext navigation
interfaces
Magnetic resonance spectroscopy
Metabolites
Permutations
Spectra
Spectral signatures
Spectroscopic analysis
Spectrum analysis
Tissues
Computing methodologies and applications
Biomedical imaging and signal processing
interfaces
Information systems (hypertext navigation
etc.
decision support
Applications to biology and medical sciences
ISSN:0097-8493, 1873-7684
Online Access:Get full text
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Summary:•SpectraMosaic allows for interactive visual analysis of MRS single voxel ratios.•With our tool, experts may analyze complete, complex metabolite signatures.•A tiered visual encoding system provides a prioritized, layered analysis approach.•The first analysis level compares user-defined metabolite groupings.•A second analysis level compares region, individual, time point, and brain state. [Display omitted] Magnetic resonance spectroscopy (MRS) is an advanced biochemical technique used to identify metabolic compounds in living tissue. While its sensitivity and specificity to chemical imbalances render it a valuable tool in clinical assessment, the results from this modality are abstract and difficult to interpret. With this design study we characterized and explored the tasks and requirements for evaluating these data from the perspective of a MRS research specialist. Our resulting tool, SpectraMosaic, links with upstream spectroscopy quantification software to provide a means for precise interactive visual analysis of metabolites with both single- and multi-peak spectral signatures. Using a layered visual approach, SpectraMosaic allows researchers to analyze any permutation of metabolites in ratio form for an entire cohort, or by sample region, individual, acquisition date, or brain activity status at the time of acquisition. A case study with three MRS researchers demonstrates the utility of our approach in rapid and iterative spectral data analysis.
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ISSN:0097-8493
1873-7684
DOI:10.1016/j.cag.2020.08.001