Inhibitors of the ATPase p97/VCP: From basic research to clinical applications

Protein homeostasis deficiencies underlie various cancers and neurodegenerative diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most of the protein degradation in mammalian cells and, therefore, represent attractive targets for cancer therapy and that of neurodegene...

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Vydané v:	Cell chemical biology Ročník 30; číslo 1; s. 3
Hlavní autori:	Kilgas, Susan, Ramadan, Kristijan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 19.01.2023
Predmet:	Adenosine Triphosphatases - metabolism Animals Cell Cycle Proteins - metabolism Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Mammals - metabolism Neoplasms - drug therapy Ubiquitin - metabolism Valosin Containing Protein - metabolism CB-5083 antimicrobial cancer therapy p97 inhibitors CB-5339 anti-inflammatory p97/VCP
ISSN:	2451-9448, 2451-9448
On-line prístup:	Zistit podrobnosti o prístupe
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