EMDR Therapy Modulates the Default Mode Network in a Subsyndromal, Traumatized Bipolar Patient

Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interv...

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Bibliographic Details
Published in:Neuropsychobiology Vol. 67; no. 3; pp. 181 - 184
Main Authors: Landin-Romero, Ramon, Novo, Patricia, Vicens, Victor, McKenna, Peter J., Santed, Antonia, Pomarol-Clotet, Edith, Salgado-Pineda, Pilar, Shapiro, Francine, Amann, Benedikt L.
Format: Journal Article
Language:English
Published: Basel, Switzerland S. Karger AG 01.04.2013
Subjects:
Adult
Bipolar Disorder - physiopathology
Bipolar Disorder - therapy
Case Report
Clinical Trials as Topic
Eye Movement Desensitization Reprocessing - methods
Female
Humans
Life Change Events
Magnetic Resonance Imaging
Memory, Short-Term - physiology
Nerve Net - physiopathology
Neuropsychological Tests
Prefrontal Cortex - physiopathology
Treatment Outcome
Functional magnetic resonance imaging
Default mode network
Bipolar disorder
EMDR therapy
Subsyndromal symptoms
n-back task
ISSN:0302-282X, 1423-0224, 1423-0224
Online Access:Get full text
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Summary:Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
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ISSN:0302-282X
1423-0224
1423-0224
DOI:10.1159/000346654