EMDR Therapy Modulates the Default Mode Network in a Subsyndromal, Traumatized Bipolar Patient

Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interv...

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Veröffentlicht in:Neuropsychobiology Jg. 67; H. 3; S. 181 - 184
Hauptverfasser: Landin-Romero, Ramon, Novo, Patricia, Vicens, Victor, McKenna, Peter J., Santed, Antonia, Pomarol-Clotet, Edith, Salgado-Pineda, Pilar, Shapiro, Francine, Amann, Benedikt L.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel, Switzerland S. Karger AG 01.04.2013
Schlagworte:
Adult
Bipolar Disorder - physiopathology
Bipolar Disorder - therapy
Case Report
Clinical Trials as Topic
Eye Movement Desensitization Reprocessing - methods
Female
Humans
Life Change Events
Magnetic Resonance Imaging
Memory, Short-Term - physiology
Nerve Net - physiopathology
Neuropsychological Tests
Prefrontal Cortex - physiopathology
Treatment Outcome
Functional magnetic resonance imaging
Default mode network
Bipolar disorder
EMDR therapy
Subsyndromal symptoms
n-back task
ISSN:0302-282X, 1423-0224, 1423-0224
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Abstract Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
AbstractList Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions.BACKGROUNDSome functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions.We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial.METHODWe report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial.The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment.RESULTSThe patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment.This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.CONCLUSIONSThis case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.
Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction. Copyright © 2013 S. Karger AG, Basel [PUBLICATION ABSTRACT]
Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction. Copyright [copy 2013 S. Karger AG, Basel
Author Shapiro, Francine
McKenna, Peter J.
Landin-Romero, Ramon
Amann, Benedikt L.
Pomarol-Clotet, Edith
Santed, Antonia
Salgado-Pineda, Pilar
Vicens, Victor
Novo, Patricia
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  surname: Vicens
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  givenname: Peter J.
  surname: McKenna
  fullname: McKenna, Peter J.
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  givenname: Antonia
  surname: Santed
  fullname: Santed, Antonia
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  givenname: Edith
  surname: Pomarol-Clotet
  fullname: Pomarol-Clotet, Edith
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  givenname: Pilar
  surname: Salgado-Pineda
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  givenname: Francine
  surname: Shapiro
  fullname: Shapiro, Francine
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  givenname: Benedikt L.
  surname: Amann
  fullname: Amann, Benedikt L.
  email: benedikt.amann@gmail.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23548794$$D View this record in MEDLINE/PubMed
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Copyright 2013 S. Karger AG, Basel
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Keywords Functional magnetic resonance imaging
Default mode network
Bipolar disorder
EMDR therapy
Subsyndromal symptoms
n-back task
Language English
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Snippet Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what...
Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these...
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StartPage 181
SubjectTerms Adult
Bipolar Disorder - physiopathology
Bipolar Disorder - therapy
Case Report
Clinical Trials as Topic
Eye Movement Desensitization Reprocessing - methods
Female
Humans
Life Change Events
Magnetic Resonance Imaging
Memory, Short-Term - physiology
Nerve Net - physiopathology
Neuropsychological Tests
Prefrontal Cortex - physiopathology
Treatment Outcome
Title EMDR Therapy Modulates the Default Mode Network in a Subsyndromal, Traumatized Bipolar Patient
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Volume 67
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