Comparing ADA and IDF diagnostic criteria for intermediate hyperglycaemia and diabetes in the SHiDS study

This study aimed to assess the prevalence of IH and diabetes, as well as insulin secretion, insulin sensitivity, and related curve patterns in subjects with different glucose tolerance categories according to the diagnostic criteria established by the American Diabetes Association (ADA) and the more...

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Bibliographic Details
Published in:Diabetes research and clinical practice Vol. 219; p. 111963
Main Authors: Zhang, Yinan, Liu, Shuang, Cao, Baige, Xu, Jinfang, Jia, Weiping, Wang, Congrong
Format: Journal Article
Language:English
Published: Ireland Elsevier B.V 01.01.2025
Subjects:
ADA
Adult
Aged
Blood Glucose - analysis
Blood Glucose - metabolism
China - epidemiology
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Female
Glucose Tolerance Test
Glycated Hemoglobin - analysis
Glycated Hemoglobin - metabolism
Humans
Hyperglycemia - blood
Hyperglycemia - diagnosis
Hyperglycemia - epidemiology
IDF
Insulin - metabolism
Insulin Resistance
Intermediate hyperglycaemia
Male
Middle Aged
SHiDS
China
SHiDS
IDF
Diabetes
Intermediate hyperglycaemia
ADA
ISSN:0168-8227, 1872-8227, 1872-8227
Online Access:Get full text
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Summary:This study aimed to assess the prevalence of IH and diabetes, as well as insulin secretion, insulin sensitivity, and related curve patterns in subjects with different glucose tolerance categories according to the diagnostic criteria established by the American Diabetes Association (ADA) and the more recently published International Diabetes Federation (IDF) guidelines. We used data of 5,387 adult participants from the Shanghai High-risk Diabetic Screen (SHiDS) study. All participants underwent a five-point 75 g oral glucose tolerance test (OGTT). Glycemic states were then classified according to the ADA/IDF diagnostic criteria, while OGTT-derived indices were employed to evaluate insulin secretion and sensitivity. Overall, 3,729 subjects were diagnosed consistently under ADA/IDF criteria; while 941 and 717 subjects exhibited inconsistencies in the diagnostic classification for diabetes and IH, respectively. Notably, all of these individuals with discrepant diagnoses displayed β-cell dysfunction and/or insulin resistance compared to the NGT/NGT group. The ADA criteria can identify individuals with elevated haemoglobinA1c (HbA1c) levels when the 1-hour plasma glucose (1-h PG) stay within the normal range, while the IDF criteria can identify subjects with impaired insulin sensitivity and secretion when fasting plasma glucose (FPG), 2-hour plasma glucose (2-h PG) and HbA1c values are in the normal range.
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ISSN:0168-8227
1872-8227
1872-8227
DOI:10.1016/j.diabres.2024.111963