Anti-embolic and anti-oxidative effects of a novel (E)-4-amino-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl) ethylidene) benzohydrazide against isoproterenol and vitamin-K induced ischemic stroke

This study aimed to evaluate the cerebroprotective potential of a novel synthetic coumarin, (E)-4-amino-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene) benzohydrazide noted (HC) against a pharmaceutically induced ischemic stroke in experimental male Wistar rats. Animals were randomly allocated in...

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Published in:Archives of physiology and biochemistry Vol. 127; no. 6; pp. 527 - 540
Main Authors: Mnafgui, Kais, Khdhiri, Emna, Ghazouani, Lakhdar, Ncir, Marwa, Zaafouri, Zouhaier, Allouche, Noureddine, Elfeki, Abdelfattah, Ammar, Houcine, Abid, Souhir, Hajji, Raouf
Format: Journal Article
Language:English
Published: England Taylor & Francis 02.11.2021
Subjects:
Animals
atrial flutter
Brain Ischemia - drug therapy
Brain Ischemia - metabolism
coumarin
fibrinogen
Ischemic Stroke
Isoproterenol
Male
myocardial infarction
Myocardium - metabolism
Oxidative Stress
Rats
Rats, Wistar
Stroke
Stroke - drug therapy
Stroke - metabolism
Vitamin K - metabolism
Vitamins
Stroke
fibrinogen
atrial flutter
coumarin
myocardial infarction
ISSN:1381-3455, 1744-4160, 1744-4160
Online Access:Get full text
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Summary:This study aimed to evaluate the cerebroprotective potential of a novel synthetic coumarin, (E)-4-amino-N′-(1-(7-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene) benzohydrazide noted (HC) against a pharmaceutically induced ischemic stroke in experimental male Wistar rats. Animals were randomly allocated into four groups: control, Stroke, Stroke + Ace (acenocoumarol) and Stroke + HC-treated group for 7 days. Our results showed that stroke group evidenced atrial flutter, significant cardiac hypertrophy (+23%) and increase in plasma level of troponin-T, with disturbance in plasma ionic levels and rise in fibrinogen rate and oxidative damages in heart and brain. Moreover, the histological findings revealed myocardium necrosis, cardiac cavity thrombi and brain injury as compared to normal rats. However, HC-treatment significantly prevents the embolic process, improves cerebral damages and mitigates the oxidative stress markers in stroke rats. Overall, HC is endowed with a thrombolytic potential against MI and stroke in such severe conditions through an anti-vit K (AVK) mechanism.
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ISSN:1381-3455
1744-4160
1744-4160
DOI:10.1080/13813455.2019.1657900