Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma

High-risk neuroblastoma is characterized by poor survival rates, and the development of improved therapeutic approaches is a priority. Temozolomide and topotecan show promising clinical activity against neuroblastoma. Poly(ADP-ribose) polymerase-1 (PARP-1) promotes DNA repair and cell survival follo...

Full description

Saved in:

Bibliographic Details
Published in:	Clinical cancer research Vol. 15; no. 4; p. 1241
Main Authors:	Daniel, Rachel A, Rozanska, Agata L, Thomas, Huw D, Mulligan, Evan A, Drew, Yvette, Castelbuono, Deborah J, Hostomsky, Zdenek, Plummer, E Ruth, Boddy, Alan V, Tweddle, Deborah A, Curtin, Nicola J, Clifford, Steven C
Format:	Journal Article
Language:	English
Published:	United States 15.02.2009
Subjects:	Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Drug Synergism Enzyme Inhibitors - pharmacology Humans Indoles - pharmacology Mice Neuroblastoma - drug therapy Neuroblastoma - pathology Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Topotecan - pharmacology Xenograft Model Antitumor Assays
ISSN:	1078-0432
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!