Next-generation T cell immunotherapy: overcoming exhaustion, senescence, and suppression

T-cells are a core component of tumor immunotherapy because of their potent ability to identify and kill cancer cells. Yet efficacy is limited by exhaustion, senescence, metabolic dysregulation, an immunosuppressive tumor microenvironment (TME), and limited persistence. This review analyzed these ke...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 16; p. 1662145
Main Authors:	Li, Guangmei, Li, Dengju, Zhu, Xiaojian
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2025
Subjects:	Animals Cellular Senescence - immunology Humans Immunotherapy - methods Immunotherapy, Adoptive - methods Lymphocyte Activation metabolic regulation microenvironment optimization Neoplasms - immunology Neoplasms - metabolism Neoplasms - therapy T-cell enhancement T-cell exhaustion and aging T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - transplantation tumor immunotherapy Tumor Microenvironment - immunology tumor immunotherapy T-cell enhancement T-cell exhaustion and aging metabolic regulation microenvironment optimization
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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