Early Diagnosis of Keratoconus in Chinese Myopic Eyes by Combining Corvis ST with Pentacam

Purpose: This study was designed to evaluate and compare the sensitivity and specificity of the Belin/Ambrósio Deviation (BADD), Corneal Biomechanical Index (CBI) and Tomographic and Biomechanical Index (TBI) for the diagnosis of keratoconus in Chinese myopic eyes prior to undergoing corneal refract...

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Published in:Current eye research Vol. 45; no. 2; pp. 118 - 123
Main Authors: Zhang, Mingyue, Zhang, Fengju, Li, Yu, Song, Yanzheng, Wang, Zhiqun
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.02.2020
Subjects:
Adolescent
Adult
Asian Continental Ancestry Group - ethnology
bilateral keratoconus
Biomechanical Phenomena
China - epidemiology
Cornea - physiopathology
Corneal Pachymetry
Corneal Topography
Corvis ST
Early Diagnosis
Elasticity - physiology
Female
forme fruste keratoconus
Humans
Keratoconus - diagnosis
Keratoconus - ethnology
Keratoconus - physiopathology
Male
Myopia - diagnosis
Myopia - ethnology
Myopia - physiopathology
Pentacam
Refractive Surgical Procedures
Retrospective Studies
ROC Curve
Sensitivity and Specificity
unilateral keratoconus
Young Adult
China
Pentacam
bilateral keratoconus
unilateral keratoconus
Corvis ST
forme fruste keratoconus
ISSN:0271-3683, 1460-2202, 1460-2202
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Summary:Purpose: This study was designed to evaluate and compare the sensitivity and specificity of the Belin/Ambrósio Deviation (BADD), Corneal Biomechanical Index (CBI) and Tomographic and Biomechanical Index (TBI) for the diagnosis of keratoconus in Chinese myopic eyes prior to undergoing corneal refractive surgery. Methods: A total of 125 patients (185 eyes) planned to undergo corneal refractive surgery were selected from the Refractive Center of Beijing Tongren Hospital between December 2017 and December 2018. They were divided into four groups: the normal group, bilateral keratoconus (BK) group, unilateral keratoconus (UK) group, and the forme fruste keratoconus (FFK) group. After determining the BADD, CBI, and TBI for each eye using the Corvis ST combined with Pentacam, the sensitivity and specificity of these three indices in diagnosing keratoconus were analyzed through receiver operating characteristic (ROC) curves. Results: The TBI exhibited the highest diagnostic efficiency in normal vs. UK (area under the ROC curve [AUROC]: 0.992), normal vs. UK+BK (AUROC: 0.988), normal vs. UK+BK* (*stand randomly selecting one eye of each patient in BK group) (AUROC: 0.982), normal vs. UK+BK+FFK (AUROC: 0.965), and normal vs. UK+BK*+FFK (AUROC: 0.953). The CBI demonstrated the highest diagnostic efficiency in normal vs. FFK (AUROC: 0.897). Finally, the BADD showed the highest diagnostic efficiency in normal vs. BK (AUROC: 0.998) and normal vs. BK* (AUROC: 0.996). Conclusion: The BADD, CBI, and TBI performed well in diagnosing keratoconus in Chinese myopic eyes. The CBI showed the highest diagnostic efficiency compared with normal for FFK. In addition, the TBI offered the greatest accuracy in detecting keratoconus and FFK eyes vs. the other parameters.
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ISSN:0271-3683
1460-2202
1460-2202
DOI:10.1080/02713683.2019.1658787