HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies

The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for latent infection. Despite the success of antiretroviral therapy (ART) in suppressing plasma viremia, HIV persists indefinitely in latently infect...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 16; p. 1650852
Main Authors:	Lau, Jillian S. Y., Lewin, Sharon R., Telwatte, Sushama
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2025
Subjects:	Animals Anti-HIV Agents - therapeutic use Gastrointestinal Microbiome - immunology gene and cell therapies gut-associated lymphoid tissue (GALT) HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV persistence HIV reservoir HIV-1 - immunology HIV-1 - physiology Humans Intestinal Mucosa - immunology Intestinal Mucosa - virology latency reversal mucosal immunity Virus Latency - drug effects Virus Latency - immunology antiretroviral penetration gut-associated lymphoid tissue (GALT) HIV cure strategies latency reversal HIV persistence gene and cell therapies HIV reservoir mucosal immunity
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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