HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies

The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for latent infection. Despite the success of antiretroviral therapy (ART) in suppressing plasma viremia, HIV persists indefinitely in latently infect...

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Vydáno v:Frontiers in immunology Ročník 16; s. 1650852
Hlavní autoři: Lau, Jillian S. Y., Lewin, Sharon R., Telwatte, Sushama
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 2025
Témata:
Animals
Anti-HIV Agents - therapeutic use
Gastrointestinal Microbiome - immunology
gene and cell therapies
gut-associated lymphoid tissue (GALT)
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV persistence
HIV reservoir
HIV-1 - immunology
HIV-1 - physiology
Humans
Intestinal Mucosa - immunology
Intestinal Mucosa - virology
latency reversal
mucosal immunity
Virus Latency - drug effects
Virus Latency - immunology
antiretroviral penetration
gut-associated lymphoid tissue (GALT)
HIV cure strategies
latency reversal
HIV persistence
gene and cell therapies
HIV reservoir
mucosal immunity
ISSN:1664-3224, 1664-3224
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Abstract The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for latent infection. Despite the success of antiretroviral therapy (ART) in suppressing plasma viremia, HIV persists indefinitely in latently infected cells, commonly found in the intestinal tract due to its unique immunological and structural environment. Targeting HIV-infected cells that persist in the intestinal tract is an important consideration for therapeutic strategies and is also important when considering an HIV cure. This review describes the therapeutic approaches aimed at addressing HIV persistence in the intestinal tract, or gut. We provide a brief overview of mechanisms underlying reservoir formation and maintenance, discuss the challenges posed by gut-specific factors, and examine emerging strategies, including latency reversal agents, immune modulation, gut-targeted ART, and novel delivery systems. This review will focus on contemporary advances in knowledge in this space, gaps in the literature and areas for future research focus.
AbstractList The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for latent infection. Despite the success of antiretroviral therapy (ART) in suppressing plasma viremia, HIV persists indefinitely in latently infected cells, commonly found in the intestinal tract due to its unique immunological and structural environment. Targeting HIV-infected cells that persist in the intestinal tract is an important consideration for therapeutic strategies and is also important when considering an HIV cure. This review describes the therapeutic approaches aimed at addressing HIV persistence in the intestinal tract, or gut. We provide a brief overview of mechanisms underlying reservoir formation and maintenance, discuss the challenges posed by gut-specific factors, and examine emerging strategies, including latency reversal agents, immune modulation, gut-targeted ART, and novel delivery systems. This review will focus on contemporary advances in knowledge in this space, gaps in the literature and areas for future research focus.The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for latent infection. Despite the success of antiretroviral therapy (ART) in suppressing plasma viremia, HIV persists indefinitely in latently infected cells, commonly found in the intestinal tract due to its unique immunological and structural environment. Targeting HIV-infected cells that persist in the intestinal tract is an important consideration for therapeutic strategies and is also important when considering an HIV cure. This review describes the therapeutic approaches aimed at addressing HIV persistence in the intestinal tract, or gut. We provide a brief overview of mechanisms underlying reservoir formation and maintenance, discuss the challenges posed by gut-specific factors, and examine emerging strategies, including latency reversal agents, immune modulation, gut-targeted ART, and novel delivery systems. This review will focus on contemporary advances in knowledge in this space, gaps in the literature and areas for future research focus.
The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for latent infection. Despite the success of antiretroviral therapy (ART) in suppressing plasma viremia, HIV persists indefinitely in latently infected cells, commonly found in the intestinal tract due to its unique immunological and structural environment. Targeting HIV-infected cells that persist in the intestinal tract is an important consideration for therapeutic strategies and is also important when considering an HIV cure. This review describes the therapeutic approaches aimed at addressing HIV persistence in the intestinal tract, or gut. We provide a brief overview of mechanisms underlying reservoir formation and maintenance, discuss the challenges posed by gut-specific factors, and examine emerging strategies, including latency reversal agents, immune modulation, gut-targeted ART, and novel delivery systems. This review will focus on contemporary advances in knowledge in this space, gaps in the literature and areas for future research focus.
Author Lau, Jillian S. Y.
Lewin, Sharon R.
Telwatte, Sushama
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Cites_doi 10.1126/science.adr8382
10.1016/0167-5699(91)90092-8
10.1089/aid.2020.0127
10.1089/aid.2016.0253
10.1172/JCI120633
10.1371/journal.ppat.1007357
10.1086/368386
10.1016/j.ebiom.2022.103840
10.1016/j.coviro.2019.03.004
10.1126/science.aaw8562
10.3389/fmicb.2023.1033448
10.1002/jia2.25738
10.1371/journal.ppat.1004473
10.1128/JVI.77.21.11708-11717.2003
10.1038/d41591-023-00042-6
10.1097/QAI.0b013e31829f6e1a
10.1371/journal.ppat.1010160
10.1086/527324
10.4049/jimmunol.1901191
10.1126/scitranslmed.aau4711
10.1038/s41385-021-00389-4
10.1371/journal.ppat.1000852
10.1016/j.omtm.2018.10.010
10.1093/cid/ciz212
10.3390/nu11071675
10.1016/j.omtm.2022.01.012
10.1073/pnas.1320178111
10.2217/nnm-2022-0248
10.1126/science.aaf1279
10.1128/JVI.75.18.8390-8399.2001
10.1128/AAC.00717-12
10.1039/D2BM01649D
10.1038/mi.2015.75
10.1016/j.celrep.2017.09.080
10.1097/QAI.0000000000000478
10.1016/j.jaut.2023.103114
10.1016/j.immuni.2017.01.009
10.1016/j.ebiom.2023.104549
10.1099/vir.0.000139
10.1056/NEJMoa1300662
10.1136/gut.2006.101386
10.1093/infdis/jiab121
10.1097/QAD.0000000000000166
10.1016/j.ijpharm.2017.09.040
10.1128/AAC.02496-13
10.1016/j.chom.2017.12.004
10.1136/gut.37.4.524
10.1093/infdis/jiz509
10.1016/j.jacc.2018.09.038
10.1097/00002030-200008180-00011
10.1093/infdis/jiz494
10.1093/cid/ciy414
10.1128/JVI.01331-20
10.1111/jmp.12613
10.1084/jem.187.6.949
10.1093/infdis/jiq115
10.1186/1742-4690-10-119
10.1086/317625
10.1038/s41385-018-0110-8
10.1016/S0140-6736(22)00538-4
10.1097/COH.0000000000000528
10.1056/NEJMoa2106516
10.1097/PAS.0b013e318162c3ec
10.1089/aid.2017.0153
10.1038/s41586-018-0600-6
10.1038/nm1380
10.2147/DDDT.S207277
10.1097/QAI.0000000000002716
10.1186/s40168-022-01247-6
10.1038/s41591-022-01815-1
10.1021/acs.molpharmaceut.8b00382
10.1126/science.aad2035
10.1186/s12985-014-0214-z
10.1016/j.celrep.2022.110514
10.1038/mi.2017.59
10.1016/j.immuni.2013.08.019
10.1038/nature16933
10.1016/j.virol.2008.07.023
10.1038/nri1057
10.1093/ecco-jcc/jjy060
10.1084/jem.20041196
10.1016/S2352-3018(16)30113-8
10.1038/nchembio.370
10.1073/pnas.1318249111
10.1016/j.cell.2014.07.043
10.1038/s41434-023-00410-4
10.1038/s41598-018-26755-0
10.1172/jci.insight.141502
10.1038/nature21435
10.1126/scitranslmed.aao4521
10.1371/journal.pone.0071879
10.1016/j.jve.2022.100082
10.3390/vaccines8030360
10.1093/infdis/jiw258
10.1038/s41467-018-05199-0
10.1097/QAD.0000000000001366
10.3389/fimmu.2025.1516419
10.1186/s12977-024-00655-w
10.1186/s40168-024-01919-5
10.1126/science.1249288
10.1097/QAI.0b013e3182986ff8
10.1097/QAD.0000000000003201
10.3389/fimmu.2022.945706
10.1089/vim.2006.0063
10.1093/cid/cix201
10.4172/2155-6113.1000302
10.1111/cei.12821
10.1126/science.aax2933
10.1073/pnas.2105927118
10.20411/pai.v1i1.100
10.1038/s41467-025-57284-w
10.1056/NEJMoa2103485
10.20411/pai.v5i1.388
10.1126/science.1198469
10.1080/19490976.2017.1334034
10.1038/mi.2016.122
10.1002/prp2.154
10.1038/ni1566
10.1128/JVI.00816-21
10.1126/scitranslmed.3000632
10.1038/s41467-025-60001-2
10.1038/nm1520
10.3389/fimmu.2022.840245
10.1186/s13072-019-0267-8
10.1038/nm1511
10.1016/j.celrep.2017.08.078
10.1038/nri3738
10.1038/372190a0
10.1097/QAI.0000000000000468
10.1007/s15010-014-0666-5
10.1016/j.biomaterials.2015.02.010
10.1186/s13063-022-06151-w
10.1128/JVI.01186-18
10.1186/s12977-016-0293-6
10.1186/s40168-024-01825-w
10.3390/pharmaceutics16030431
10.4049/jimmunol.1700105
10.1016/j.immuni.2020.02.001
10.1371/journal.ppat.1006740
10.3390/nu12072112
10.1093/infdis/jiaf117
10.1126/science.274.5289.985
10.1126/science.aag1276
10.1093/infdis/jiu515
10.1038/s41467-023-41966-4
10.1172/jci.insight.182312
10.1038/mi.2009.90
10.1038/s41541-021-00307-6
10.1038/mi.2015.133
10.4049/jimmunol.1501243
10.3389/fimmu.2021.708806
10.1126/scitranslmed.aax3447
10.4049/jimmunol.151.9.5031
10.4103/0975-7406.76478
10.1097/QAI.0000000000000301
10.1161/ATVBAHA.109.187518
10.1016/j.xphs.2020.06.019
10.4049/jimmunol.161.1.209
10.1093/infdis/jiz423
10.1371/journal.ppat.1004543
10.1097/QAD.0000000000001427
10.1093/cid/ciad199
10.3389/fimmu.2014.00255
10.1016/S0016-5085(99)70014-4
10.1038/nm.4411
10.1038/srep28896
10.2147/IJN.S502833
10.1084/jem.20040874
10.1038/mi.2009.104
10.1038/s41586-018-0531-2
10.1097/QAD.0000000000000174
10.1371/journal.pone.0183372
10.1186/s12879-022-07256-y
10.1208/s12249-018-1262-2
10.1097/QAD.0000000000002684
10.1073/pnas.0911796106
10.1038/s41467-021-21472-1
10.1186/s12981-016-0103-1
10.1155/2015/120605
10.1128/JVI.72.8.6646-6656.1998
10.4049/jimmunol.2101102
10.3205/id000018
10.4049/jimmunol.153.2.517
10.1038/s41587-023-01906-5
10.1056/NEJMoa2101016
10.2174/138920012798356899
10.1016/j.jaad.2015.11.043
10.3390/vaccines11111663
10.1038/srep43741
10.1093/nar/gkv469
10.1084/jem.20090858
10.1038/nm.3781
10.1016/j.omtn.2024.102372
10.3389/fmicb.2019.03060
10.3748/wjg.v21.i8.2563
10.1128/JVI.00235-18
10.1038/s41385-020-0286-6
10.1111/j.1365-2249.1997.236-ce1111.x
10.1126/sciadv.aav2045
10.1371/journal.ppat.1008339
10.1097/QAD.0b013e3283471d10
10.1371/journal.ppat.1009831
10.1086/314660
10.1128/JVI.01739-06
10.1074/jbc.M111.248021
10.3390/nu14050992
10.1186/s12977-022-00600-9
10.1371/journal.pone.0121290
10.1093/cid/ciz1001
10.1172/JCI126714
10.1038/s41591-021-01651-9
10.1086/323615
10.1016/j.biomaterials.2012.01.029
10.1038/s41417-025-00886-9
10.1038/mi.2013.1
10.1111/imr.12079
10.1182/bloodadvances.2017012971
10.1126/scitranslmed.abg3071
10.1038/mi.2011.15
10.1097/QAD.0000000000001771
10.1016/j.jconrel.2021.10.006
10.1038/s41586-024-08466-x
10.1172/JCI63039
10.1038/ni.2025
10.1172/JCI59011
10.4049/jimmunol.144.2.480
10.1097/QAI.0000000000002287
10.1186/1471-2334-13-203
10.1186/s12974-018-1126-4
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Keywords antiretroviral penetration
gut-associated lymphoid tissue (GALT)
HIV cure strategies
latency reversal
HIV persistence
gene and cell therapies
HIV reservoir
mucosal immunity
Language English
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References Mendoza (B152) 2018; 561
Xu (B25) 2014; 5
Willis (B195) 2025; 2025
Kooij (B12) 2016; 186
Shao (B42) 2023; 141
Kyosiimire-Lugemwa (B157) 2020; 222
Estes (B210) 2017; 23
Lu (B149) 2016; 352
Breen (B60) 1990; 144
Uzzan (B122) 2018; 10
Lee (B154) 2022; 23
Mock (B214) 2015; 43
Vujkovic-Cvijin (B170) 2017; 8
Fletcher (B83) 2022; 36
Van der Sluis (B135) 2020; 204
Bozzi (B85) 2019; 5
Delany-Moretlwe (B88) 2022; 399
Thompson (B5) 2013
McManus (B86) 2019; 129
Yukl (B55) 2020; 95
Assimakopoulos (B31) 2014; 42
Levy (B202) 2005; 19
Isnard (B70) 2020; 221
Feuerstadt (B165) 2022; 386
Mehraj (B67) 2020; 70
Zhang (B53) 2013; 39
Ibrahim (B147) 2025; 32
D’Haese (B194) 2024; 35
Borducchi (B100) 2018; 563
Lorenzo-Redondo (B84) 2016; 530
Wang (B120) 2009; 2
Serrano-Villar (B161) 2019; 68
Pampusch (B217) 2022; 18
Toribio (B176) 2017; 31
Bachhav (B219) 2017; 532
Joshi (B106) 2011; 286
Webb (B140) 2020; 16
Anton (B3) 2000; 14
Xie (B35) 2022; 208
Kumar (B54) 2017; 20
Cevaal (B208) 2025; 16
Villar-Garcia (B158) 2015; 68
Mackay (B56) 2016; 352
Chun (B1) 2008; 197
Ortiz (B146) 2016; 9
B211
Elizalde-Torrent (B205) 2023; 11
Thompson (B89) 2017; 33
Carvalho (B218) 2023; 29
Brenchley (B29) 2006; 12
Missailidis (B167) 2019; 11
Julg (B151) 2022; 28
Gay (B136) 2021; 87
Jaimalai (B232) 2020; 109
Boisvert (B183) 2008; 380
Gori (B160) 2011; 4
Barber-Axthelm (B216) 2021; 6
Gubser (B134) 2022; 76
Daskou (B189) 2022; 18
Beltran (B179) 2006; 55
Haase (B125) 1996; 274
Sarnelli (B182) 2018; 15
Ranasinghe (B190) 2013; 6
Yukl (B34) 2015; 10
Telwatte (B36) 2018; 14
Li (B213) 2015; 96
McGowan (B7) 2016; 3
Erle (B116) 1994; 153
Masopust (B50) 2010; 207
Mudd (B80) 2016
Niu (B105) 2019; 129
Dempsey (B164) 2022; 13
Monroe (B225) 2023; 11
Farris (B13) 2008; 32
Lee (B82) 2020; 83
Hussain (B173) 2021; 37
Petrovas (B124) 2012; 122
Shaikh (B227) 2011; 3
Karra (B233) 2012; 13
Poles (B4) 2001; 75
Garrido (B138) 2018; 92
Funderburg (B181) 2023; 77
Cheuk (B57) 2017; 46
Kim (B108) 2016; 6
Ait-Ammar (B93) 2019; 10
Noel (B62) 2014; 28
Tenner-Racz (B123) 1998; 187
da Costa (B207) 2022; 19
Senda (B33) 2019; 12
Byrareddy (B127) 2016; 354
Mowat (B9) 2003; 3
Morbe (B11) 2021; 14
Mehandru (B17) 2004; 200
Kader (B119) 2009; 2
Ruane (B191) 2016; 9
Zerbato (B92) 2019; 38
Cohn (B192) 2014; 5
Mu (B198) 2022; 38
Sainz (B163) 2022; 14
Wahl (B75) 2024; 42
Serrano-Villar (B159) 2017; 10
Burdo (B206) 2024; 31
SenGupta (B101) 2021; 13
Olsson (B2) 2000; 182
Epeldegui (B66) 2018; 32
Tanaka (B91) 2022; 51
Chattopadhyay (B188) 2018; 8
Moyo (B199) 2019; 12
Ameisen (B28) 1991; 12
Anderson (B107) 2014; 111
Fukazawa (B126) 2015; 21
Gavegnano (B112) 2017; 13
Paiardini (B74) 2013; 254
Hong (B14) 2015; 21
Lim (B94) 2018; 10
Zheng (B169) 2017; 199
Webb (B139) 2018; 2
Utay (B171) 2020; 5
Mortha (B40) 2014; 343
Favre (B61) 2010; 2
Masia (B8) 2025; 231
Jimenez-Leon (B98) 2023; 91
Serrano-Villar (B78) 2021; 12
Li (B215) 2022; 24
Navab (B186) 2010; 30
Fan (B59) 1993; 151
Briskin (B115) 1997; 151
Jimenez-Leon (B131) 2024; 9
Lamb (B133) 2018; 12
Funderburg (B175) 2015; 68
Mavigner (B132) 2012; 122
Gavegnano (B111) 2014; 58
Miller (B137) 2022; 28
Zhang (B184) 2019; 13
Vibholm (B95) 2017; 64
Mehandru (B63) 2007; 81
Guadalupe (B22) 2003; 77
Kang (B68) 2018; 9
Duan (B97) 2021; 95
Chamcha (B193) 2015; 195
Cepek (B52) 1994; 372
Deleage (B209) 2016; 1
Nathan (B144) 2021; 385
Brenchley (B18) 2004; 200
Wiche Salinas (B45) 2021; 118
Christ (B110) 2012; 56
Borgognone (B76) 2022; 10
Hoang (B145) 2019; 14
Tudesq (B65) 2017; 12
Fletcher (B81) 2014; 111
Singh (B230) 2021; 340
Nayrac (B44) 2021; 14
Cicala (B118) 2009; 106
Bahraoui (B185) 2014; 11
Tincati (B79) 2016; 13
Fenton (B32) 2020; 52
Marchetti (B64) 2011; 25
Pinto-Cardoso (B69) 2017; 7
Soares (B58) 1998; 161
Hsue (B178) 2018; 72
Saunders (B196) 2021; 6
Jones (B203) 2010; 11
Ganesan (B174) 2011; 203
Khan (B43) 2017; 33
Vajdy (B21) 2001; 184
Veazey (B23) 2003; 187
Christ (B109) 2010; 6
Kewenig (B20) 1999; 116
Arthos (B117) 2008; 9
Maek (B49) 2007; 20
Chattopadhyay (B187) 2015; 3
Kiepiela (B197) 2007; 13
Umotoy (B231) 2021; 12
Wu (B143) 2021; 224
Orenstein (B166) 2022; 22
Wacleche (B48) 2016; 13
Telwatte (B39) 2020; 34
Krarup (B99) 2018; 11
Moyo (B200) 2020; 8
Tebas (B212) 2014; 370
Valentin (B201) 2022; 13
Sainz (B162) 2020; 12
Garbati (B220) 2024; 16
Sarparanta (B226) 2012; 33
Schneider (B15) 1995; 37
Moron-Lopez (B38) 2021; 24
Hasan (B224) 2025; 20
Tenorio (B156) 2015; 211
Shreya (B222) 2018; 20
Smit-McBride (B19) 1998; 72
Abbink (B129) 2019; 365
Kessing (B114) 2017; 21
Halper-Stromberg (B148) 2014; 158
Wallace (B141) 2022; 8
Sonnenberg (B46) 2011; 12
Long (B229) 2025; 16
Hoenigl (B72) 2015; 3
Ramendra (B73) 2020; 71
Elliott (B104) 2014; 10
Bjerg Christensen (B103) 2015; 2015
Li (B113) 2019; 12
Soare (B177) 2019; 93
Marin-Sanchez (B77) 2024; 21
Brenchley (B155) 2024; 12
Nishimura (B150) 2017; 543
Yukl (B37) 2014; 28
Spreen (B6) 2014; 67
Clayton (B16) 1997; 107
Mowat (B10) 2014; 14
Gallitano (B180) 2016; 74
Atarashi (B41) 2011; 331
Kim (B90) 2018; 23
Bachhav (B228) 2018; 15
Bailon (B204) 2025; 16
Graf (B142) 2013; 8
Giorgi (B26) 1999; 179
Anderson (B47) 2020; 221
Berg (B128) 2019; 363
Suphaphiphat (B153) 2023; 14
Diaz-Garcia (B172) 2024; 12
Grossman (B27) 2006; 12
Asl (B223) 2023; 18
Nazli (B30) 2010; 6
Schuetz (B24) 2014; 10
Sneller (B130) 2019; 11
Kim (B221) 2015; 52
Novis (B96) 2013; 10
Martinelli (B121) 2013; 64
Reina-Campos (B51) 2025; 639
Li (B102) 2023; 14
Cassol (B71) 2013; 13
Landovitz (B87) 2021; 385
Dillon (B168) 2017; 31
References_xml – volume: 2025
  start-page: eadr8382
  year: 2025
  ident: B195
  article-title: Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans
  publication-title: Science
  doi: 10.1126/science.adr8382
– volume: 12
  year: 1991
  ident: B28
  article-title: Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis
  publication-title: Immunol Today
  doi: 10.1016/0167-5699(91)90092-8
– volume: 37
  year: 2021
  ident: B173
  article-title: Effect of statin use on inflammation and immune activation biomarkers in HIV-infected persons on effective antiretroviral therapy
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2020.0127
– volume: 33
  year: 2017
  ident: B89
  article-title: HIV persistence in gut-associated lymphoid tissues: pharmacological challenges and opportunities
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2016.0253
– volume: 129
  year: 2019
  ident: B105
  article-title: Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV
  publication-title: J Clin Invest
  doi: 10.1172/JCI120633
– volume: 14
  start-page: e1007357
  year: 2018
  ident: B36
  article-title: Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1007357
– volume: 187
  year: 2003
  ident: B23
  article-title: Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection
  publication-title: J Infect Dis
  doi: 10.1086/368386
– volume: 76
  start-page: 103840
  year: 2022
  ident: B134
  article-title: Immune checkpoint blockade in HIV
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2022.103840
– volume: 38
  start-page: 1
  year: 2019
  ident: B92
  article-title: Between a shock and a hard place: challenges and developments in HIV latency reversal
  publication-title: Curr Opin Virol
  doi: 10.1016/j.coviro.2019.03.004
– volume: 365
  year: 2019
  ident: B129
  article-title: Lack of therapeutic efficacy of an antibody to alpha(4)beta(7) in SIVmac251-infected rhesus macaques
  publication-title: Science
  doi: 10.1126/science.aaw8562
– volume: 14
  year: 2023
  ident: B102
  article-title: Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2023.1033448
– volume: 24
  start-page: e25738
  year: 2021
  ident: B38
  article-title: Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women
  publication-title: J Int AIDS Soc
  doi: 10.1002/jia2.25738
– volume: 10
  start-page: e1004473
  year: 2014
  ident: B104
  article-title: Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1004473
– volume: 77
  year: 2003
  ident: B22
  article-title: Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
  publication-title: J Virol
  doi: 10.1128/JVI.77.21.11708-11717.2003
– volume: 29
  year: 2023
  ident: B218
  article-title: First two patients receive CAR T cell therapy for HIV
  publication-title: Nat Med
  doi: 10.1038/d41591-023-00042-6
– volume: 64
  year: 2013
  ident: B121
  article-title: The frequency of alpha(4)beta(7)(high) memory CD4(+) T cells correlates with susceptibility to rectal simian immunodeficiency virus infection
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0b013e31829f6e1a
– volume: 18
  year: 2022
  ident: B189
  article-title: ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1010160
– volume: 197
  year: 2008
  ident: B1
  article-title: Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
  publication-title: J Infect Dis
  doi: 10.1086/527324
– volume: 204
  year: 2020
  ident: B135
  article-title: Combination immune checkpoint blockade to reverse HIV latency
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1901191
– volume: 10
  year: 2018
  ident: B122
  article-title: Anti-alpha4beta7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1-infected individuals
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aau4711
– volume: 14
  start-page: 793
  year: 2021
  ident: B11
  article-title: Human gut-associated lymphoid tissues (GALT); diversity, structure, and function
  publication-title: Mucosal Immunol
  doi: 10.1038/s41385-021-00389-4
– volume: 6
  start-page: e1000852
  year: 2010
  ident: B30
  article-title: Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1000852
– volume: 12
  start-page: 32
  year: 2019
  ident: B199
  article-title: Efficient Induction of T Cells against Conserved HIV-1 Regions by Mosaic Vaccines Delivered as Self-Amplifying mRNA
  publication-title: Mol Ther Methods Clin Dev
  doi: 10.1016/j.omtm.2018.10.010
– volume: 70
  year: 2020
  ident: B67
  article-title: Circulating (1–>3)-beta-D-glucan is associated with immune activation during human immunodeficiency virus infection
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciz212
– volume: 11
  year: 2019
  ident: B167
  article-title: Vitamin D and phenylbutyrate supplementation does not modulate gut derived immune activation in HIV-1
  publication-title: Nutrients
  doi: 10.3390/nu11071675
– volume: 24
  year: 2022
  ident: B215
  article-title: CRISPR-Cas9-mediated gene disruption of HIV-1 co-receptors confers broad resistance to infection in human T cells and humanized mice
  publication-title: Mol Ther Methods Clin Dev
  doi: 10.1016/j.omtm.2022.01.012
– volume: 111
  year: 2014
  ident: B107
  article-title: Heat shock protein 90 controls HIV-1 reactivation from latency
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1320178111
– volume: 18
  start-page: 279
  year: 2023
  ident: B223
  article-title: Nano drug-delivery systems for management of AIDS: liposomes, dendrimers, gold and silver nanoparticles
  publication-title: Nanomed (Lond)
  doi: 10.2217/nnm-2022-0248
– volume: 352
  year: 2016
  ident: B149
  article-title: Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1
  publication-title: vivo Sci
  doi: 10.1126/science.aaf1279
– volume: 75
  year: 2001
  ident: B4
  article-title: A preponderance of CCR5(+) CXCR4(+) mononuclear cells enhances gastrointestinal mucosal susceptibility to human immunodeficiency virus type 1 infection
  publication-title: J Virol
  doi: 10.1128/JVI.75.18.8390-8399.2001
– volume: 56
  year: 2012
  ident: B110
  article-title: Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.00717-12
– volume: 11
  year: 2023
  ident: B225
  article-title: Antiviral supramolecular polymeric hydrogels by self-assembly of tenofovir-bearing peptide amphiphiles
  publication-title: Biomater Sci
  doi: 10.1039/D2BM01649D
– volume: 9
  year: 2016
  ident: B146
  article-title: IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2015.75
– volume: 21
  year: 2017
  ident: B114
  article-title: In vivo suppression of HIV rebound by didehydro-cortistatin A, a “Block-and-lock” Strategy for HIV-1 treatment
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2017.09.080
– volume: 68
  start-page: 396
  year: 2015
  ident: B175
  article-title: Rosuvastatin reduces vascular inflammation and T-cell and monocyte activation in HIV-infected subjects on antiretroviral therapy
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0000000000000478
– volume: 141
  start-page: 103114
  year: 2023
  ident: B42
  article-title: The gut ecosystem and immune tolerance
  publication-title: J Autoimmun
  doi: 10.1016/j.jaut.2023.103114
– volume: 46
  start-page: 287
  year: 2017
  ident: B57
  article-title: CD49a expression defines tissue-resident CD8(+) T cells poised for cytotoxic function in human skin
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.01.009
– volume: 91
  start-page: 104549
  year: 2023
  ident: B98
  article-title: Toll-like receptor agonists enhance HIV-specific T cell response mediated by plasmacytoid dendritic cells in diverse HIV-1 disease progression phenotypes
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2023.104549
– volume: 96
  year: 2015
  ident: B213
  article-title: Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.000139
– volume: 370
  year: 2014
  ident: B212
  article-title: Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1300662
– volume: 55
  year: 2006
  ident: B179
  article-title: Safe and effective application of anti-TNF-alpha in a patient infected with HIV and concomitant Crohn’s disease
  publication-title: Gut
  doi: 10.1136/gut.2006.101386
– volume: 224
  year: 2021
  ident: B143
  article-title: Gag p24 is a marker of human immunodeficiency virus expression in tissues and correlates with immune response
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiab121
– volume: 28
  year: 2014
  ident: B37
  article-title: A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cells
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000000166
– volume: 532
  year: 2017
  ident: B219
  article-title: Rifampicin Lipid-Polymer hybrid nanoparticles (LIPOMER) for enhanced Peyer’s patch uptake
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2017.09.040
– volume: 58
  year: 2014
  ident: B111
  article-title: Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.02496-13
– volume: 23
  start-page: 14
  year: 2018
  ident: B90
  article-title: Getting the “Kill” into “Shock and kill”: strategies to eliminate latent HIV
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2017.12.004
– volume: 37
  year: 1995
  ident: B15
  article-title: Loss of CD4 T lymphocytes in patients infected with human immunodeficiency virus type 1 is more pronounced in the duodenal mucosa than in the peripheral blood
  publication-title: Berlin Diarrhea/Wasting Syndrome Study Group Gut
  doi: 10.1136/gut.37.4.524
– volume: 221
  year: 2020
  ident: B47
  article-title: Human immunodeficiency virus (HIV)-infected CCR6+ Rectal CD4+ T cells and HIV persistence on antiretroviral therapy
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiz509
– volume: 72
  year: 2018
  ident: B178
  article-title: IL-1beta inhibition reduces atherosclerotic inflammation in HIV infection
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2018.09.038
– volume: 14
  year: 2000
  ident: B3
  article-title: Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue
  publication-title: AIDS
  doi: 10.1097/00002030-200008180-00011
– volume: 222
  year: 2020
  ident: B157
  article-title: Effect of stopping cotrimoxazole preventive therapy on microbial translocation and inflammatory markers among human immunodeficiency virus-infected Ugandan adults on antiretroviral therapy: the COSTOP trial immunology substudy
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiz494
– volume: 68
  year: 2019
  ident: B161
  article-title: Effects of immunonutrition in advanced human immunodeficiency virus disease: A randomized placebo-controlled clinical trial (Promaltia study)
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciy414
– volume: 95
  year: 2020
  ident: B55
  article-title: Shared mechanisms govern HIV transcriptional suppression in circulating CD103(+) and gut CD4(+) T cells
  publication-title: J Virol
  doi: 10.1128/JVI.01331-20
– volume: 51
  year: 2022
  ident: B91
  article-title: The role of latency reversal in HIV cure strategies
  publication-title: J Med Primatol
  doi: 10.1111/jmp.12613
– volume: 187
  year: 1998
  ident: B123
  article-title: The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy
  publication-title: J Exp Med
  doi: 10.1084/jem.187.6.949
– volume: 203
  year: 2011
  ident: B174
  article-title: High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiq115
– volume: 10
  start-page: 119
  year: 2013
  ident: B96
  article-title: Reactivation of latent HIV-1 in central memory CD4(+) T cells through TLR-1/2 stimulation
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-10-119
– volume: 182
  year: 2000
  ident: B2
  article-title: Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and beta-chemokines
  publication-title: J Infect Dis
  doi: 10.1086/317625
– volume: 12
  year: 2019
  ident: B33
  article-title: Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life
  publication-title: Mucosal Immunol
  doi: 10.1038/s41385-018-0110-8
– volume: 399
  year: 2022
  ident: B88
  article-title: Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)00538-4
– volume: 14
  year: 2019
  ident: B145
  article-title: Role of cytokine agonists and immune checkpoint inhibitors toward HIV remission
  publication-title: Curr Opin HIV AIDS
  doi: 10.1097/COH.0000000000000528
– volume: 386
  year: 2022
  ident: B165
  article-title: SER-109, an oral microbiome therapy for recurrent clostridioides difficile infection
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2106516
– volume: 32
  year: 2008
  ident: B13
  article-title: The rectal tonsil: a reactive lymphoid proliferation that may mimic lymphoma
  publication-title: Am J Surg Pathol
  doi: 10.1097/PAS.0b013e318162c3ec
– ident: B211
– volume: 33
  year: 2017
  ident: B43
  article-title: Differentiating immune cell targets in gut-associated lymphoid tissue for HIV cure
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2017.0153
– volume: 563
  year: 2018
  ident: B100
  article-title: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
  publication-title: Nature
  doi: 10.1038/s41586-018-0600-6
– volume: 12
  year: 2006
  ident: B27
  article-title: Pathogenesis of HIV infection: what the virus spares is as important as what it destroys
  publication-title: Nat Med
  doi: 10.1038/nm1380
– volume: 13
  year: 2019
  ident: B184
  article-title: The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease
  publication-title: Drug Des Devel Ther
  doi: 10.2147/DDDT.S207277
– volume: 87
  year: 2021
  ident: B136
  article-title: Suspected immune-related adverse events with an anti-PD-1 inhibitor in otherwise healthy people with HIV
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0000000000002716
– volume: 10
  start-page: 59
  year: 2022
  ident: B76
  article-title: Gut microbiome signatures linked to HIV-1 reservoir size and viremia control
  publication-title: Microbiome
  doi: 10.1186/s40168-022-01247-6
– volume: 28
  year: 2022
  ident: B151
  article-title: Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial
  publication-title: Nat Med
  doi: 10.1038/s41591-022-01815-1
– volume: 15
  year: 2018
  ident: B228
  article-title: Exploring peyer’s patch uptake as a strategy for targeted lung delivery of polymeric rifampicin nanoparticles
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.8b00382
– volume: 352
  year: 2016
  ident: B56
  article-title: Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
  publication-title: Science
  doi: 10.1126/science.aad2035
– volume: 11
  start-page: 214
  year: 2014
  ident: B185
  article-title: E5564 inhibits immunosuppressive cytokine IL-10 induction promoted by HIV-1 Tat protein
  publication-title: Virol J
  doi: 10.1186/s12985-014-0214-z
– volume: 38
  start-page: 110514
  year: 2022
  ident: B198
  article-title: mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2022.110514
– volume: 11
  year: 2018
  ident: B99
  article-title: The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2017.59
– volume: 39
  year: 2013
  ident: B53
  article-title: Transforming growth factor-beta signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.019
– volume: 530
  year: 2016
  ident: B84
  article-title: Persistent HIV-1 replication maintains the tissue reservoir during therapy
  publication-title: Nature
  doi: 10.1038/nature16933
– volume: 380
  start-page: 1
  year: 2008
  ident: B183
  article-title: PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells
  publication-title: Virology
  doi: 10.1016/j.virol.2008.07.023
– volume: 3
  year: 2003
  ident: B9
  article-title: Anatomical basis of tolerance and immunity to intestinal antigens
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1057
– volume: 12
  year: 2018
  ident: B133
  article-title: Gut-selective integrin-targeted therapies for inflammatory bowel disease
  publication-title: J Crohns Colitis
  doi: 10.1093/ecco-jcc/jjy060
– volume: 200
  year: 2004
  ident: B17
  article-title: Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
  publication-title: J Exp Med
  doi: 10.1084/jem.20041196
– volume: 3
  year: 2016
  ident: B7
  article-title: Long-acting rilpivirine as potential pre-exposure prophylaxis for HIV-1 prevention (the MWRI-01 study): an open-label, phase 1, compartmental, pharmacokinetic and pharmacodynamic assessment
  publication-title: Lancet HIV
  doi: 10.1016/S2352-3018(16)30113-8
– volume: 6
  year: 2010
  ident: B109
  article-title: Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.370
– volume: 111
  year: 2014
  ident: B81
  article-title: Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1318249111
– volume: 158
  year: 2014
  ident: B148
  article-title: Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
  publication-title: Cell
  doi: 10.1016/j.cell.2014.07.043
– volume: 31
  year: 2024
  ident: B206
  article-title: Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates
  publication-title: Gene Ther
  doi: 10.1038/s41434-023-00410-4
– volume: 8
  start-page: 9032
  year: 2018
  ident: B188
  article-title: Treating the intestine with oral apoA-I mimetic tg6F reduces tumor burden in mouse models of metastatic lung cancer
  publication-title: Sci Rep
  doi: 10.1038/s41598-018-26755-0
– volume: 6
  year: 2021
  ident: B216
  article-title: Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.141502
– volume: 543
  year: 2017
  ident: B150
  article-title: Early antibody therapy can induce long-lasting immunity to SHIV
  publication-title: Nature
  doi: 10.1038/nature21435
– volume: 10
  year: 2018
  ident: B94
  article-title: TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aao4521
– volume: 8
  start-page: e71879
  year: 2013
  ident: B142
  article-title: Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected
  publication-title: PloS One
  doi: 10.1371/journal.pone.0071879
– volume: 8
  start-page: 100082
  year: 2022
  ident: B141
  article-title: Combination strategies to durably suppress HIV-1: Soluble T cell receptors
  publication-title: J Virus Erad
  doi: 10.1016/j.jve.2022.100082
– volume: 8
  year: 2020
  ident: B200
  article-title: Tetravalent immunogen assembled from conserved regions of HIV-1 and delivered as mRNA demonstrates potent preclinical T-cell immunogenicity and breadth
  publication-title: Vaccines (Basel)
  doi: 10.3390/vaccines8030360
– year: 2016
  ident: B80
  article-title: Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiw258
– volume: 9
  start-page: 2747
  year: 2018
  ident: B68
  article-title: Molecular architecture of fungal cell walls revealed by solid-state NMR
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-05199-0
– volume: 31
  year: 2017
  ident: B168
  article-title: Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000001366
– volume: 16
  year: 2025
  ident: B229
  article-title: Antibody-drug conjugates in cancer therapy: applications and future advances
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2025.1516419
– volume: 21
  start-page: 21
  year: 2024
  ident: B77
  article-title: Exploring potential associations between the human microbiota and reservoir of latent HIV
  publication-title: Retrovirology
  doi: 10.1186/s12977-024-00655-w
– volume: 12
  start-page: 214
  year: 2024
  ident: B172
  article-title: Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers
  publication-title: Microbiome
  doi: 10.1186/s40168-024-01919-5
– volume: 343
  start-page: 1249288
  year: 2014
  ident: B40
  article-title: Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis
  publication-title: Science
  doi: 10.1126/science.1249288
– year: 2013
  ident: B5
  article-title: Antiretroviral pharmacology in mucosal tissues
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0b013e3182986ff8
– volume: 36
  year: 2022
  ident: B83
  article-title: Persistent HIV transcription and variable antiretroviral drug penetration in lymph nodes during plasma viral suppression
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000003201
– volume: 13
  year: 2022
  ident: B201
  article-title: Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.945706
– volume: 20
  start-page: 66
  year: 2007
  ident: B49
  article-title: Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection
  publication-title: Viral Immunol
  doi: 10.1089/vim.2006.0063
– volume: 64
  year: 2017
  ident: B95
  article-title: Short-course toll-like receptor 9 agonist treatment impacts innate immunity and plasma viremia in individuals with human immunodeficiency virus infection
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/cix201
– volume: 5
  year: 2014
  ident: B25
  article-title: Th17 cells coordinate with th22 cells in maintaining homeostasis of intestinal tissues and both are depleted in SIV-infected macaques
  publication-title: J AIDS Clin Res
  doi: 10.4172/2155-6113.1000302
– volume: 186
  start-page: 1
  year: 2016
  ident: B12
  article-title: The immunology of the vermiform appendix: a review of the literature
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.12821
– volume: 363
  start-page: 1406
  year: 2019
  ident: B128
  article-title: Editorial expression of concern
  publication-title: Science
  doi: 10.1126/science.aax2933
– volume: 118
  year: 2021
  ident: B45
  article-title: Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2105927118
– volume: 1
  start-page: 68
  year: 2016
  ident: B209
  article-title: Defining HIV and SIV reservoirs in lymphoid tissues
  publication-title: Pathog Immun
  doi: 10.20411/pai.v1i1.100
– volume: 16
  start-page: 2146
  year: 2025
  ident: B204
  article-title: Safety, immunogenicity and effect on viral rebound of HTI vaccines combined with a TLR7 agonist in early-treated HIV-1 infection: a randomized, placebo-controlled phase 2a trial
  publication-title: Nat Commun
  doi: 10.1038/s41467-025-57284-w
– volume: 385
  year: 2021
  ident: B144
  article-title: Overall survival benefit with tebentafusp in metastatic uveal melanoma
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2103485
– volume: 5
  year: 2020
  ident: B171
  article-title: Evaluation of six weekly oral fecal microbiota transplants in people with HIV
  publication-title: Pathog Immun
  doi: 10.20411/pai.v5i1.388
– volume: 331
  year: 2011
  ident: B41
  article-title: Induction of colonic regulatory T cells by indigenous Clostridium species
  publication-title: Science
  doi: 10.1126/science.1198469
– volume: 8
  year: 2017
  ident: B170
  article-title: Limited engraftment of donor microbiome via one-time fecal microbial transplantation in treated HIV-infected individuals
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2017.1334034
– volume: 10
  year: 2017
  ident: B159
  article-title: The effects of prebiotics on microbial dysbiosis, butyrate production and immunity in HIV-infected subjects
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2016.122
– volume: 3
  start-page: e00154
  year: 2015
  ident: B187
  article-title: Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer
  publication-title: Pharmacol Res Perspect
  doi: 10.1002/prp2.154
– volume: 9
  year: 2008
  ident: B117
  article-title: HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells
  publication-title: Nat Immunol
  doi: 10.1038/ni1566
– volume: 95
  start-page: e0081621
  year: 2021
  ident: B97
  article-title: TLR1/2 agonist enhances reversal of HIV-1 latency and promotes NK cell-induced suppression of HIV-1-infected autologous CD4(+) T cells
  publication-title: J Virol
  doi: 10.1128/JVI.00816-21
– volume: 2
  start-page: 32ra6
  year: 2010
  ident: B61
  article-title: Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3000632
– volume: 16
  start-page: 4979
  year: 2025
  ident: B208
  article-title: Efficient mRNA delivery to resting T cells to reverse HIV latency
  publication-title: Nat Commun
  doi: 10.1038/s41467-025-60001-2
– volume: 151
  start-page: 97
  year: 1997
  ident: B115
  article-title: Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue
  publication-title: Am J Pathol
– volume: 13
  start-page: 46
  year: 2007
  ident: B197
  article-title: CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
  publication-title: Nat Med
  doi: 10.1038/nm1520
– volume: 13
  year: 2022
  ident: B164
  article-title: Lactobacillus spp. for gastrointestinal health: current and future perspectives
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.840245
– volume: 12
  start-page: 23
  year: 2019
  ident: B113
  article-title: Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat
  publication-title: Epigenet Chromatin
  doi: 10.1186/s13072-019-0267-8
– volume: 12
  year: 2006
  ident: B29
  article-title: Microbial translocation is a cause of systemic immune activation in chronic HIV infection
  publication-title: Nat Med
  doi: 10.1038/nm1511
– volume: 20
  year: 2017
  ident: B54
  article-title: Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2017.08.078
– volume: 14
  year: 2014
  ident: B10
  article-title: Regional specialization within the intestinal immune system
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3738
– volume: 372
  year: 1994
  ident: B52
  article-title: Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin
  publication-title: Nature
  doi: 10.1038/372190a0
– volume: 68
  year: 2015
  ident: B158
  article-title: Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients: a double-blind, randomized, placebo-controlled trial
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0000000000000468
– volume: 42
  year: 2014
  ident: B31
  article-title: Intestinal barrier dysfunction in HIV infection: pathophysiology, clinical implications and potential therapies
  publication-title: Infection
  doi: 10.1007/s15010-014-0666-5
– volume: 52
  year: 2015
  ident: B221
  article-title: Chitosan-catechol: a polymer with long-lasting mucoadhesive properties
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2015.02.010
– volume: 23
  start-page: 263
  year: 2022
  ident: B154
  article-title: The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection-study protocol for a two-stage randomised phase II trial
  publication-title: Trials
  doi: 10.1186/s13063-022-06151-w
– volume: 93
  year: 2019
  ident: B177
  article-title: P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines interleukin-10 (IL-10) and IL-1beta in a human tonsil explant model
  publication-title: J Virol
  doi: 10.1128/JVI.01186-18
– volume: 13
  start-page: 59
  year: 2016
  ident: B48
  article-title: New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy
  publication-title: Retrovirology
  doi: 10.1186/s12977-016-0293-6
– volume: 12
  start-page: 113
  year: 2024
  ident: B155
  article-title: From dysbiosis to defense: harnessing the gut microbiome in HIV/SIV therapy
  publication-title: Microbiome
  doi: 10.1186/s40168-024-01825-w
– volume: 16
  start-page: 431
  year: 2024
  ident: B220
  article-title: Targeting the gut: A systematic review of specific drug nanocarriers
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics16030431
– volume: 199
  year: 2017
  ident: B169
  article-title: Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1700105
– volume: 52
  start-page: 557
  year: 2020
  ident: B32
  article-title: Immune profiling of human gut-associated lymphoid tissue identifies a role for isolated lymphoid follicles in priming of region-specific immunity
  publication-title: Immunity
  doi: 10.1016/j.immuni.2020.02.001
– volume: 13
  start-page: e1006740
  year: 2017
  ident: B112
  article-title: Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1006740
– volume: 12
  year: 2020
  ident: B162
  article-title: Effect of a nutritional intervention on the intestinal microbiota of vertically HIV-infected children: the pediabiota study
  publication-title: Nutrients
  doi: 10.3390/nu12072112
– volume: 231
  year: 2025
  ident: B8
  article-title: Impact of switching to long-acting injectable cabotegravir plus rilpivirine on rectal HIV-1 RNA shedding and implications for transmission risk
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiaf117
– volume: 274
  year: 1996
  ident: B125
  article-title: Quantitative image analysis of HIV-1 infection in lymphoid tissue
  publication-title: Science
  doi: 10.1126/science.274.5289.985
– volume: 354
  start-page: 197
  year: 2016
  ident: B127
  article-title: Sustained virologic control in SIV+ macaques after antiretroviral and alpha4beta7 antibody therapy
  publication-title: Science
  doi: 10.1126/science.aag1276
– volume: 211
  year: 2015
  ident: B156
  article-title: Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune non-responders to antiretroviral therapy - ACTG A5286
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiu515
– volume: 14
  start-page: 6224
  year: 2023
  ident: B153
  article-title: Mucosal application of the broadly neutralizing antibody 10–1074 protects macaques from cell-associated SHIV vaginal exposure
  publication-title: Nat Commun
  doi: 10.1038/s41467-023-41966-4
– volume: 9
  year: 2024
  ident: B131
  article-title: Vedolizumab and ART in recent HIV-1 infection unveil the role of alpha4beta7 in reservoir size
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.182312
– volume: 2
  year: 2009
  ident: B119
  article-title: Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2009.90
– volume: 6
  start-page: 50
  year: 2021
  ident: B196
  article-title: Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
  publication-title: NPJ Vaccines
  doi: 10.1038/s41541-021-00307-6
– volume: 9
  year: 2016
  ident: B191
  article-title: A dendritic cell targeted vaccine induces long-term HIV-specific immunity within the gastrointestinal tract
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2015.133
– volume: 195
  year: 2015
  ident: B193
  article-title: Oral immunization with a recombinant lactococcus lactis-expressing HIV-1 antigen on group A streptococcus pilus induces strong mucosal immunity in the gut
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1501243
– volume: 12
  year: 2021
  ident: B231
  article-title: Antibody conjugates for targeted therapy against HIV-1 as an emerging tool for HIV-1 cure
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.708806
– volume: 11
  year: 2019
  ident: B130
  article-title: An open-label phase 1 clinical trial of the anti-alpha(4)beta(7) monoclonal antibody vedolizumab in HIV-infected individuals
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aax3447
– volume: 151
  year: 1993
  ident: B59
  article-title: Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.151.9.5031
– volume: 3
  start-page: 89
  year: 2011
  ident: B227
  article-title: Mucoadhesive drug delivery systems
  publication-title: J Pharm Bioallied Sci
  doi: 10.4103/0975-7406.76478
– volume: 67
  year: 2014
  ident: B6
  article-title: GSK1265744 pharmacokinetics in plasma and tissue after single-dose long-acting injectable administration in healthy subjects
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0000000000000301
– volume: 30
  year: 2010
  ident: B186
  article-title: Structure and function of HDL mimetics
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.109.187518
– volume: 109
  year: 2020
  ident: B232
  article-title: Drug delivery system targeting CD4(+) T cells for HIV-1 latency reactivation towards the viral eradication
  publication-title: J Pharm Sci
  doi: 10.1016/j.xphs.2020.06.019
– volume: 161
  year: 1998
  ident: B58
  article-title: V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.161.1.209
– volume: 221
  year: 2020
  ident: B70
  article-title: Plasma levels of C-type lectin REG3alpha and gut damage in people with human immunodeficiency virus
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiz423
– volume: 11
  year: 2010
  ident: B203
  article-title: Vacc-4x, a therapeutic vaccine comprised of four engineered peptides for the potential treatment of HIV infection
  publication-title: Curr Opin Investig Drugs
– volume: 10
  start-page: e1004543
  year: 2014
  ident: B24
  article-title: Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1004543
– volume: 31
  start-page: 797
  year: 2017
  ident: B176
  article-title: Effects of pitavastatin and pravastatin on markers of immune activation and arterial inflammation in HIV
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000001427
– volume: 77
  year: 2023
  ident: B181
  article-title: Interleukin 6 blockade with tocilizumab diminishes indices of inflammation that are linked to mortality in treated human immunodeficiency virus infection
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciad199
– volume: 5
  year: 2014
  ident: B192
  article-title: Dendritic cell-targeted vaccines
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2014.00255
– volume: 116
  year: 1999
  ident: B20
  article-title: Rapid mucosal CD4(+) T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaques
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(99)70014-4
– volume: 23
  year: 2017
  ident: B210
  article-title: Defining total-body AIDS-virus burden with implications for curative strategies
  publication-title: Nat Med
  doi: 10.1038/nm.4411
– volume: 6
  start-page: 28896
  year: 2016
  ident: B108
  article-title: Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner
  publication-title: Sci Rep
  doi: 10.1038/srep28896
– volume: 20
  year: 2025
  ident: B224
  article-title: Localized drug delivery in different gastrointestinal cancers: navigating challenges and advancing nanotechnological solutions
  publication-title: Int J Nanomed
  doi: 10.2147/IJN.S502833
– volume: 200
  year: 2004
  ident: B18
  article-title: CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
  publication-title: J Exp Med
  doi: 10.1084/jem.20040874
– volume: 2
  year: 2009
  ident: B120
  article-title: Monitoring alpha4beta7 integrin expression on circulating CD4+ T cells as a surrogate marker for tracking intestinal CD4+ T-cell loss in SIV infection
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2009.104
– volume: 561
  year: 2018
  ident: B152
  article-title: Combination therapy with anti-HIV-1 antibodies maintains viral suppression
  publication-title: Nature
  doi: 10.1038/s41586-018-0531-2
– volume: 19
  year: 2005
  ident: B202
  article-title: Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients
  publication-title: AIDS
– volume: 28
  year: 2014
  ident: B62
  article-title: Elevated IP10 levels are associated with immune activation and low CD4(+) T-cell counts in HIV controller patients
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000000174
– volume: 12
  start-page: e0183372
  year: 2017
  ident: B65
  article-title: Microbial translocation is correlated with HIV evolution in HIV-HCV co-infected patients
  publication-title: PloS One
  doi: 10.1371/journal.pone.0183372
– volume: 22
  start-page: 245
  year: 2022
  ident: B166
  article-title: Durable reduction of Clostridioides difficile infection recurrence and microbiome restoration after treatment with RBX2660: results from an open-label phase 2 clinical trial
  publication-title: BMC Infect Dis
  doi: 10.1186/s12879-022-07256-y
– volume: 20
  start-page: 15
  year: 2018
  ident: B222
  article-title: Active targeting of drugs and bioactive molecules via oral administration by ligand-conjugated lipidic nanocarriers: recent advances
  publication-title: AAPS PharmSciTech
  doi: 10.1208/s12249-018-1262-2
– volume: 34
  year: 2020
  ident: B39
  article-title: Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000002684
– volume: 106
  year: 2009
  ident: B118
  article-title: The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0911796106
– volume: 12
  start-page: 1139
  year: 2021
  ident: B78
  article-title: Fecal microbiota transplantation in HIV: A pilot placebo-controlled study
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-21472-1
– volume: 13
  start-page: 19
  year: 2016
  ident: B79
  article-title: Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection
  publication-title: AIDS Res Ther
  doi: 10.1186/s12981-016-0103-1
– volume: 2015
  start-page: 120605
  year: 2015
  ident: B103
  article-title: Administration of panobinostat is associated with increased IL-17A mRNA in the intestinal epithelium of HIV-1 patients
  publication-title: Mediators Inflamm
  doi: 10.1155/2015/120605
– volume: 72
  year: 1998
  ident: B19
  article-title: Gastrointestinal T lymphocytes retain high potential for cytokine responses but have severe CD4(+) T-cell depletion at all stages of simian immunodeficiency virus infection compared to peripheral lymphocytes
  publication-title: J Virol
  doi: 10.1128/JVI.72.8.6646-6656.1998
– volume: 208
  year: 2022
  ident: B35
  article-title: Common and divergent features of T cells from blood, gut, and genital tract of antiretroviral therapy-treated HIV(+) women
  publication-title: J Immunol
  doi: 10.4049/jimmunol.2101102
– volume: 3
  year: 2015
  ident: B72
  article-title: Correlation of (1–>3)-beta-D-glucan with other inflammation markers in chronically HIV infected persons on suppressive antiretroviral therapy
  publication-title: GMS Infect Dis
  doi: 10.3205/id000018
– volume: 153
  year: 1994
  ident: B116
  article-title: Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes
  publication-title: J Immunol
  doi: 10.4049/jimmunol.153.2.517
– volume: 42
  year: 2024
  ident: B75
  article-title: A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-023-01906-5
– volume: 385
  start-page: 595
  year: 2021
  ident: B87
  article-title: Cabotegravir for HIV prevention in cisgender men and transgender women
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2101016
– volume: 13
  start-page: 22
  year: 2012
  ident: B233
  article-title: The ligand nanoparticle conjugation approach for targeted cancer therapy
  publication-title: Curr Drug Metab
  doi: 10.2174/138920012798356899
– volume: 74
  year: 2016
  ident: B180
  article-title: Use of tumor necrosis factor (TNF) inhibitors in patients with HIV/AIDS
  publication-title: J Am Acad Dermatol
  doi: 10.1016/j.jaad.2015.11.043
– volume: 11
  year: 2023
  ident: B205
  article-title: Vaccination with an HIV T-cell immunogen (HTI) using DNA primes followed by a chAdOx1-MVA boost is immunogenic in gut microbiota-depleted mice despite low IL-22 serum levels
  publication-title: Vaccines (Basel)
  doi: 10.3390/vaccines11111663
– volume: 7
  start-page: 43741
  year: 2017
  ident: B69
  article-title: Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens
  publication-title: Sci Rep
  doi: 10.1038/srep43741
– volume: 43
  year: 2015
  ident: B214
  article-title: mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkv469
– volume: 207
  year: 2010
  ident: B50
  article-title: Dynamic T cell migration program provides resident memory within intestinal epithelium
  publication-title: J Exp Med
  doi: 10.1084/jem.20090858
– volume: 21
  year: 2015
  ident: B126
  article-title: B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
  publication-title: Nat Med
  doi: 10.1038/nm.3781
– volume: 35
  start-page: 102372
  year: 2024
  ident: B194
  article-title: The role of mRNA-galsomes and LNPs in enhancing HIV-specific T cell responses across various lymphoid organs
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2024.102372
– volume: 10
  year: 2019
  ident: B93
  article-title: Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2019.03060
– volume: 21
  year: 2015
  ident: B14
  article-title: Rectal tonsil: a case report and literature review
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v21.i8.2563
– volume: 92
  year: 2018
  ident: B138
  article-title: Interleukin-15-stimulated natural killer cells clear HIV-1-infected cells following latency reversal ex vivo
  publication-title: J Virol
  doi: 10.1128/JVI.00235-18
– volume: 14
  year: 2021
  ident: B44
  article-title: Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals
  publication-title: Mucosal Immunol
  doi: 10.1038/s41385-020-0286-6
– volume: 107
  year: 1997
  ident: B16
  article-title: Selective depletion of rectal lamina propria rather than lymphoid aggregate CD4 lymphocytes in HIV infection
  publication-title: Clin Exp Immunol
  doi: 10.1111/j.1365-2249.1997.236-ce1111.x
– volume: 5
  year: 2019
  ident: B85
  article-title: No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication
  publication-title: Sci Adv
  doi: 10.1126/sciadv.aav2045
– volume: 16
  start-page: e1008339
  year: 2020
  ident: B140
  article-title: The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1008339
– volume: 25
  year: 2011
  ident: B64
  article-title: Microbial translocation predicts disease progression of HIV-infected antiretroviral-naive patients with high CD4+ cell count
  publication-title: AIDS
  doi: 10.1097/QAD.0b013e3283471d10
– volume: 18
  start-page: e1009831
  year: 2022
  ident: B217
  article-title: CAR/CXCR5-T cell immunotherapy is safe and potentially efficacious in promoting sustained remission of SIV infection
  publication-title: PloS Pathog
  doi: 10.1371/journal.ppat.1009831
– volume: 179
  year: 1999
  ident: B26
  article-title: Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
  publication-title: J Infect Dis
  doi: 10.1086/314660
– volume: 81
  start-page: 599
  year: 2007
  ident: B63
  article-title: Mechanisms of gastrointestinal CD4+ T-cell depletion during acute and early human immunodeficiency virus type 1 infection
  publication-title: J Virol
  doi: 10.1128/JVI.01739-06
– volume: 286
  year: 2011
  ident: B106
  article-title: Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.248021
– volume: 14
  year: 2022
  ident: B163
  article-title: Targeting the gut microbiota of vertically HIV-infected children to decrease inflammation and immunoactivation: A pilot clinical trial
  publication-title: Nutrients
  doi: 10.3390/nu14050992
– volume: 19
  start-page: 12
  year: 2022
  ident: B207
  article-title: Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
  publication-title: Retrovirology
  doi: 10.1186/s12977-022-00600-9
– volume: 10
  start-page: e0121290
  year: 2015
  ident: B34
  article-title: Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adults
  publication-title: PloS One
  doi: 10.1371/journal.pone.0121290
– volume: 71
  year: 2020
  ident: B73
  article-title: Cytomegalovirus seropositivity is associated with increased microbial translocation in people living with human immunodeficiency virus and uninfected controls
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciz1001
– volume: 129
  year: 2019
  ident: B86
  article-title: HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy
  publication-title: J Clin Invest
  doi: 10.1172/JCI126714
– volume: 28
  start-page: 392
  year: 2022
  ident: B137
  article-title: Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial
  publication-title: Nat Med
  doi: 10.1038/s41591-021-01651-9
– volume: 184
  year: 2001
  ident: B21
  article-title: Early immunologic events in mucosal and systemic lymphoid tissues after intrarectal inoculation with simian immunodeficiency virus
  publication-title: J Infect Dis
  doi: 10.1086/323615
– volume: 33
  year: 2012
  ident: B226
  article-title: The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.01.029
– volume: 32
  year: 2025
  ident: B147
  article-title: MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy
  publication-title: Cancer Gene Ther
  doi: 10.1038/s41417-025-00886-9
– volume: 6
  year: 2013
  ident: B190
  article-title: Unique IL-13Ralpha2-based HIV-1 vaccine strategy to enhance mucosal immunity, CD8(+) T-cell avidity and protective immunity
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2013.1
– volume: 254
  start-page: 78
  year: 2013
  ident: B74
  article-title: HIV-associated chronic immune activation
  publication-title: Immunol Rev
  doi: 10.1111/imr.12079
– volume: 2
  start-page: 76
  year: 2018
  ident: B139
  article-title: The human IL-15 superagonist ALT-803 directs SIV-specific CD8(+) T cells into B-cell follicles
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2017012971
– volume: 13
  year: 2021
  ident: B101
  article-title: The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.abg3071
– volume: 4
  year: 2011
  ident: B160
  article-title: Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2011.15
– volume: 32
  year: 2018
  ident: B66
  article-title: A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000001771
– volume: 340
  start-page: 1
  year: 2021
  ident: B230
  article-title: Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2021.10.006
– volume: 639
  year: 2025
  ident: B51
  article-title: Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
  publication-title: Nature
  doi: 10.1038/s41586-024-08466-x
– volume: 122
  year: 2012
  ident: B124
  article-title: CD4 T follicular helper cell dynamics during SIV infection
  publication-title: J Clin Invest
  doi: 10.1172/JCI63039
– volume: 12
  year: 2011
  ident: B46
  article-title: Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
  publication-title: Nat Immunol
  doi: 10.1038/ni.2025
– volume: 122
  year: 2012
  ident: B132
  article-title: Altered CD4+ T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals
  publication-title: J Clin Invest
  doi: 10.1172/JCI59011
– volume: 144
  year: 1990
  ident: B60
  article-title: Infection with HIV is associated with elevated IL-6 levels and production
  publication-title: J Immunol
  doi: 10.4049/jimmunol.144.2.480
– volume: 83
  year: 2020
  ident: B82
  article-title: Antiretroviral therapy concentrations differ in gut vs. Lymph node tissues and are associated with HIV viral transcription by a novel RT-ddPCR assay
  publication-title: J Acquir Immune Defic Syndr
  doi: 10.1097/QAI.0000000000002287
– volume: 13
  start-page: 203
  year: 2013
  ident: B71
  article-title: Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors
  publication-title: BMC Infect Dis
  doi: 10.1186/1471-2334-13-203
– volume: 15
  start-page: 94
  year: 2018
  ident: B182
  article-title: HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia
  publication-title: J Neuroinflamm
  doi: 10.1186/s12974-018-1126-4
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Snippet The intestinal immune compartment plays a central role in HIV pathogenesis, serving as an early site for viral replication and a significant reservoir for...
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SubjectTerms Animals
Anti-HIV Agents - therapeutic use
Gastrointestinal Microbiome - immunology
gene and cell therapies
gut-associated lymphoid tissue (GALT)
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV persistence
HIV reservoir
HIV-1 - immunology
HIV-1 - physiology
Humans
Intestinal Mucosa - immunology
Intestinal Mucosa - virology
latency reversal
mucosal immunity
Virus Latency - drug effects
Virus Latency - immunology
Title HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies
URI https://www.ncbi.nlm.nih.gov/pubmed/41050701
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Volume 16
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