Stent placement with iodine-125 seeds strand effectively extends the duration of stent patency and survival in patients with unresectable malignant obstructive jaundice

Background: This study aimed to compare the treatment outcomes and safety between stent placement with or without Iodine- 125 ( 125 I) seeds strand for patients with unresectable malignant obstructive jaundice (MOJ). Methods: A total of 84 patients with unresectable MOJ treated in our hospital were...

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Vydané v:	Scandinavian journal of gastroenterology Ročník 55; číslo 1; s. 123 - 128
Hlavní autori:	Pan, Tao, Li, Ming-an, Mu, Lu-wen, Zhu, Duo, Qian, Jie-sheng, Li, Zheng-ran
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis 02.01.2020
Predmet:	iodine-125 radioactive stent Malignant obstructive jaundice primary patency stent placement primary patency iodine-125 radioactive stent stent placement Malignant obstructive jaundice
ISSN:	0036-5521, 1502-7708, 1502-7708
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Shrnutí:	Background: This study aimed to compare the treatment outcomes and safety between stent placement with or without Iodine- 125 ( 125 I) seeds strand for patients with unresectable malignant obstructive jaundice (MOJ). Methods: A total of 84 patients with unresectable MOJ treated in our hospital were retrospectively included and divided into the stent group (n = 54) undergoing biliary stent placement and the stent + seeds group (n = 30) receiving stent placement with 125 I seeds strand. The therapeutic outcome, postoperative complications, duration of patient survival and stent patency were compared between groups. Kaplan-Meier survival analysis was performed to compare the duration of patient survival and stent patency between groups. Cox-regression analysis was performed to investigate predictive factors for disease-free survival and overall survival. Results: The stent + seeds group had significantly longer duration of patency (231.57 ± 256.54 vs. 110.37 ± 120.52) and overall survival (310.57 ± 330.54 vs. 173.15 ± 219.40) than the stent group (both p < .05). In addition, Kaplan-Meier survival analysis confirmed that the stent + seeds group had longer duration of patency (log-rank test, p = .001) and higher overall survival rate (log-rank test, p = .020) than the stent group. Furthermore, Cox-regression analysis demonstrated that treatment methods was an independent factor associated with disease-free survival (HR: 0.36, 95% CI: 0.19-0.70; p = .003) and overall survival (HR: 1.01, 95% CI: 1.00-1.01; p < .001). Conclusion: The stent placement with 125 I seeds strand can significantly improve the primary patency rate and overall survival time in MOJ patients.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-5521 1502-7708 1502-7708
DOI:	10.1080/00365521.2019.1707275