Development of potent HLA-A02:01-restricted peptide-based cytotoxic T-cells against SARS-CoV-2 infections in patients awaiting a kidney transplant

Controlling viral infections prior to solid organ transplantation is vital for successful engraftment and overall well-being of patients. One promising approach involves the deployment of viral antigen-specific cytotoxic T cells to eradicate viral pathogens. Although there have been attempts to deve...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 16; p. 1664371
Main Authors:	Chang, Chih-Chao, Liu, Ya Nan, Xu, Zheng, Vasilescu, Elena-Rodica, Li, Ping, Ho, Eric K., Li, Muyang, Husain, Syed A., Bhagat, Govind, Mohan, Sumit, Vlad, George, Suciu-Foca, Nicole
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2025
Subjects:	Adult Aged CD8-Positive T-Lymphocytes - immunology cell-mediated immunity COVID-19 COVID-19 - immunology COVID-19 - therapy Female HLA-A2 Antigen - immunology Humans Kidney Transplantation Male Middle Aged organ transplant Peptides - immunology SARS-CoV-2 SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - immunology T-cell therapy T-Lymphocytes, Cytotoxic - immunology tetramer COVID-19 SARS-CoV-2 immunophenotyping organ transplant antigen specific-cytotoxic T cells tetramer T-cell therapy cell-mediated immunity
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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