Signal Alteration in the Optic Nerve Head on 3D T2-weighted MRI: a Potential Neuroimaging Sign of Glaucomatous Optic Neuropathy

Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls unde...

Full description

Saved in:
Bibliographic Details
Published in:Current eye research Vol. 43; no. 3; pp. 397 - 405
Main Authors: Lee, Jong Yeon, Kwon, Hyo Jeong, Park, Su Jin, Yoo, Chungkwon, Kim, Yong Yeon, Kim, Eung Yeop
Format: Journal Article
Language:English
Published: England Taylor & Francis 04.03.2018
Subjects:
Adult
Aged
Female
Glaucoma
Glaucoma, Open-Angle - complications
Glaucoma, Open-Angle - diagnosis
Humans
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Nerve Fibers - pathology
Optic Disk - pathology
optic nerve head
Optic Neuritis - diagnosis
Optic Neuritis - etiology
optic-disk cup volume
Retinal Ganglion Cells - pathology
retinal nerve fiber layer thickness
Tomography, Optical Coherence - methods
Visual Fields
Glaucoma
magnetic resonance imaging
retinal nerve fiber layer thickness
optic nerve head
optic-disk cup volume
ISSN:0271-3683, 1460-2202, 1460-2202
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: To investigate whether a signal alteration (SA) in the optic nerve head (ONH) on 3D T2-weighted magnetic resonance imaging (MRI) is associated with glaucomatous optic neuropathy Materials and Methods: A total of 35 patients with bilateral open-angle glaucoma and 31 age-matched controls underwent 3D high-resolution (0.98 × 0.98 × 1 mm 3 ) T2-weighted MRI and detailed ophthalmologic examinations including spectral-domain optical coherence tomography (OCT). Two independent reviewers blinded to subject data determined mild or prominent SA on 3D T2-weighted MRI for the incomplete or complete loss of ocular hypointense continuity in the ONH, respectively. The prevalence of SAs was compared between the two groups with the chi-square test. The OCT measurements were compared among the eyes with a mild or prominent SA and those without an SA using the Kruskal-Wallis test. Results: Of the 35 eyes with glaucoma, 26 eyes (74.3%) exhibited an SA in the ONH, whereas it was observed in 5 (16.1%) of the 31 controls (P < 0.001). The eyes with a prominent SA had a significantly different average retinal nerve fiber layer thickness (P = 0.002) and the ONH parameters except for the disk area (all P < 0.001) than those without an SA. The eyes with a mild SA had a significantly narrower neural rim area, larger cup volume, and larger average and vertical cup-to-disk ratios compared with those without an SA (P = 0.011, 0.003, 0.004, and 0.004, respectively) Conclusions: The SA in the ONH on 3D T2-weighted MRI was significantly more frequent in eyes with open-angle glaucoma than in the controls.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0271-3683
1460-2202
1460-2202
DOI:10.1080/02713683.2017.1399426