Clinic vs. daily life gait characteristics in patients with spinocerebellar ataxia
Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility. We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsup...
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| Veröffentlicht in: | Frontiers in digital health Jg. 7; S. 1590150 |
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| Abstract | Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.
We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.
Twenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann-Whitney
-tests and area under the curve (AUC).
Ten gait measures were significantly worse in SCA than HC for the clinic test (
< 0.003), but only 3 were worse in daily life (
< 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (
< 0.0001) and 0.96 (
< 0.0001) in the clinic, and 0.84 (
< 0.0003) and 0.80 (
< 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50-0.77) than between daily life gait measures (r = 0.31-0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (
> 0.06).
Digital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights. |
|---|---|
| AbstractList | Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.
We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.
Twenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann-Whitney
-tests and area under the curve (AUC).
Ten gait measures were significantly worse in SCA than HC for the clinic test (
< 0.003), but only 3 were worse in daily life (
< 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (
< 0.0001) and 0.96 (
< 0.0001) in the clinic, and 0.84 (
< 0.0003) and 0.80 (
< 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50-0.77) than between daily life gait measures (r = 0.31-0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (
> 0.06).
Digital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights. BackgroundRecent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.ObjectiveWe compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.MethodsTwenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann–Whitney U-tests and area under the curve (AUC).ResultsTen gait measures were significantly worse in SCA than HC for the clinic test (p < 0.003), but only 3 were worse in daily life (p < 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (p < 0.0001) and 0.96 (p < 0.0001) in the clinic, and 0.84 (p < 0.0003) and 0.80 (p < 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50–0.77) than between daily life gait measures (r = 0.31–0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (p > 0.06).ConclusionsDigital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights. Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.BackgroundRecent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.ObjectiveWe compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.Twenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann-Whitney U-tests and area under the curve (AUC).MethodsTwenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann-Whitney U-tests and area under the curve (AUC).Ten gait measures were significantly worse in SCA than HC for the clinic test (p < 0.003), but only 3 were worse in daily life (p < 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (p < 0.0001) and 0.96 (p < 0.0001) in the clinic, and 0.84 (p < 0.0003) and 0.80 (p < 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50-0.77) than between daily life gait measures (r = 0.31-0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (p > 0.06).ResultsTen gait measures were significantly worse in SCA than HC for the clinic test (p < 0.003), but only 3 were worse in daily life (p < 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (p < 0.0001) and 0.96 (p < 0.0001) in the clinic, and 0.84 (p < 0.0003) and 0.80 (p < 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50-0.77) than between daily life gait measures (r = 0.31-0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (p > 0.06).Digital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights.ConclusionsDigital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights. |
| Author | Shah, Vrutangkumar V. Sowalsky, Kristen Carlson-Kuhta, Patricia Safarpour, Delaram Jagodinsky, Adam Horak, Fay B. Gomez, Christopher M. Casey, Hannah Muzyka, Daniel El-Gohary, Mahmoud McNames, James |
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| Cites_doi | 10.1002/mds.28313 10.1002/mds.28343 10.1007/s00415-020-09696-5 10.1016/j.gaitpost.2017.12.031 10.1016/j.gaitpost.2017.06.267 10.1002/mds.28740 10.1016/j.jpsychores.2010.09.008 10.1007/s13311-018-00696-y 10.1016/j.jns.2015.09.004 10.1016/S1474-4422(15)00202-1 10.1038/s41582-018-0051-6 10.1007/s12311-011-0296-8 10.1002/mds.29757 10.1002/mds.25706 10.1212/01.wnl.0000219042.60538.92 10.3233/JPD-201914 10.1186/s40673-015-0028-9 10.1088/1361-6579/ab4023 10.1007/s11910-021-01101-6 10.1186/s12984-020-00781-4 10.1002/mds.29742 10.1002/mds.30230 10.1002/mds.27372 10.1002/mds.22288 10.1016/j.nrleng.2015.09.002 10.1007/s12311-016-0837-2 10.1093/brain/awaf154 10.4172/2155-9538.s1-007 10.1007/s12311-016-0836-3 10.1007/s12311-023-01608-3 10.1007/s00415-013-7189-3 10.1016/j.gaitpost.2017.03.019 10.1016/j.gaitpost.2017.04.013 10.1111/ncn3.12174 10.1016/j.gaitpost.2017.11.024 10.1007/s12311-023-01625-2 10.1007/s12311-014-0583-2 10.1212/WNL.0000000000010176 |
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| Keywords | IMUs wearable technology gait spinocerebellar ataxia daily life monitoring |
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We compared gait measures that best differentiated... Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.BackgroundRecent findings suggest that a single gait... BackgroundRecent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.ObjectiveWe compared gait measures that best... |
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| Title | Clinic vs. daily life gait characteristics in patients with spinocerebellar ataxia |
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